DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and wor

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_476601.1	Gene:	wor / 34906	FlyBaseID:	FBgn0001983	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	139/654 - (21%)
Similarity:	221/654 - (33%)	Gaps:	188/654 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DFWQQARAPFGLQTALHQYSSPP-----NQQPISHHALHHSVPQENEQLAGVQPEGPAAGSGVVG 120
            |..:.:|.|...:..:.:.|||.     ::.|:.......:||.|...:|..:|| |......:.
  Fly     2 DKLKYSRCPLKKRPIMVEESSPEDHLSHDEGPVDLSVASAAVPMEPHWMAKSEPE-PQPVPTELR 65

  Fly   121 NNSSMAISGTNSTVGSK--AESSHI----PQQHSEQQ--------SYGSDSFRGTQ-----SPQL 166
            .....|::.|...:..:  .|:..|    |...:.::        .||.......:     .|:.
  Fly    66 RRFDAAMNQTKEQLARRIWEETREIARAFPDVFTREEIAKSLARLGYGEFELPPEEEVMEPEPEP 130

  Fly   167 SSHHLLFNAAAAAAAAVHLKSTAMQNNLSPIGDQVQNNLRNYGQGSLNALCGIKPKQEM-DAKTP 230
            ..|..|.....|:...:..:.:          |:.|..||||....|.::...:...:| :.|..
  Fly   131 EQHLPLRYTRDASPTIIKAEPS----------DEEQFPLRNYNNNLLKSIAEYEDCMKMQNIKEE 185

  Fly   231 LQPLDECPHPLVQAQAQSQYGGDYYDVADPQAREISEGRALIIGLGAPSTVSTDDAQSSAPSHQL 295
            :.|:   |.|.:           :|....|              |..|..:|....:..:.:..|
  Fly   186 IPPI---PSPQL-----------FYPPPTP--------------LAEPEDLSVTQRRVLSENMNL 222

  Fly   296 AGTGRALQTHQCKPMSPGTVGSSNLGAGRRSAPTTISKTFSQGQQSPQHSTTP---SGGSTTPDI 357
            ....|||                                .|....:|||:..|   .......||
  Fly   223 QNVARAL--------------------------------LSMQHMAPQHAPPPIDMEEDQENQDI 255

  Fly   358 KYNNDKMANEIQLQLSRSSSAAAISERTLEECWSTLQRLFMHKS--AMQQIQQQIPRVGLGTHG- 419
            .....|.:|::..|..:.:           :|::|...|..|:.  |.:..:.:|.|...|..|
  Fly   256 NQLKIKSSNDLYYQCQQCN-----------KCYATYAGLVKHQQTHAYESTEYKIIRSQPGGSGA 309

  Fly   420 --------------VTGSANLGGSITPSSDTKP-----HQCQQCMKSFSSNHQLVQHIRVHTG-- 463
                          :..:||:..:   .|..||     :.||.|.||:|:...|.:|.:.|..
  Fly   310 IVDQTEFCTDQASALIQAANVASA---QSMQKPVGVPRYHCQDCGKSYSTYSGLSKHQQFHCPSA 371

  Fly   464 -----EKPYKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQV 523
                 :|.:.|..||:.:..|..::.|.|.||  .|.||  |.||:||.:...||.|:|.|..:
  Fly   372 EGNQVKKVFSCKNCDKTYVSLGALKMHIRTHT--LPCKC--PICGKAFSRPWLLQGHIRTHTGE- 431

  Fly   524 ERAKNRPFHCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIGGPNATSCPVCHKLFLGTEA 588
                 :||.|..|.:.||..|:||.|    :|.|..|.:.           |||.|.|.|.....
  Fly   432 -----KPFSCQHCNRAFADRSNLRAH----MQTHSDVKKY-----------SCPTCTKSFSRMSL 476

  Fly   589 LVDHMKH-VHKEKSPPPGGSASSQFSELNQIVTGNGNGTGSSNEQIATQCTTES-NSHQ----AT 647
            |..|::. ...|:|..|.||               |.|......|...|...|. |.||    .:
  Fly   477 LAKHLQSGCQTEQSGGPSGS---------------GGGFDQQQLQQHLQVYEEGHNPHQLYYAGS 526

  Fly   648 VGSS 651
            ||||
  Fly   527 VGSS 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	29/93 (31%)
		C2H2 Zn finger	441..461	CDD:275368	8/19 (42%)
		zf-H2C2_2	454..478	CDD:290200	7/30 (23%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..508	CDD:290200	12/26 (46%)
		C2H2 Zn finger	497..519	CDD:275368	10/21 (48%)
		C2H2 Zn finger	533..557	CDD:275368	9/23 (39%)
		C2H2 Zn finger	576..594	CDD:275368	7/17 (41%)
		C2H2 Zn finger	667..687	CDD:275370
		C2H2 Zn finger	702..719	CDD:275370
wor	NP_476601.1	C2H2 Zn finger	270..290	CDD:275368	4/30 (13%)
		C2H2 Zn finger	317..334	CDD:275368	2/19 (11%)
		zf-C2H2	345..367	CDD:278523	8/21 (38%)
		C2H2 Zn finger	347..367	CDD:275368	8/19 (42%)
		PHA00732	379..>417	CDD:177300	16/41 (39%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		zf-C2H2_8	405..482	CDD:292531	34/99 (34%)
		zf-C2H2	406..428	CDD:278523	11/23 (48%)
		C2H2 Zn finger	408..428	CDD:275368	10/21 (48%)
		zf-H2C2_2	421..444	CDD:290200	9/28 (32%)
		zf-C2H2	434..456	CDD:278523	10/25 (40%)
		C2H2 Zn finger	436..456	CDD:275368	9/23 (39%)
		zf-H2C2_2	448..473	CDD:290200	12/39 (31%)
		C2H2 Zn finger	464..481	CDD:275368	6/16 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100