DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and CG12299

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	196/884 - (22%)
Similarity:	294/884 - (33%)	Gaps:	318/884 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 TVGSKAESSHI--------PQQHSEQQSYGSDSFRGTQSPQLSSHHLLFNAAAAAAAAVH-LKST 188
            |:....:.:|:        |||..:|          .|.|.|:     |:....|...|| |...
  Fly    15 TITPILQQTHLLPQQAPNPPQQQPQQ----------PQPPDLT-----FHCMCCAEFFVHPLALY 64

  Fly   189 AMQNNLSPIGDQVQNNLRNYGQGSLNALCGIKPKQEMDAKTPLQPLDECPHPLVQAQAQSQYGGD 253
            ...|.|.|         ...|.|          :||.::     |.||              ..|
  Fly    65 QHMNTLHP---------HEPGNG----------QQEQES-----PGDE--------------SED 91

  Fly   254 YYDVADP------QAREISEGRALIIGLGAPSTVSTDDAQSSAPSHQLAGTGRALQTHQCKPMSP 312
            |..:.:|      ...:.|:|.|   ..|:.|:.|:||.........                |.
  Fly    92 YSWIFEPVCELAEDGSDSSDGSA---SSGSDSSSSSDDDDDDDDDDS----------------SS 137

  Fly   313 GTVGSSNLGAGRRSAPTTISKTFSQGQQS--PQHSTTPSGGSTTPDIKYNNDKMANEIQLQLS-- 373
            .:..|||..:...|.|||.:....|.|:|  |.|......|             .||.|||::
  Fly   138 SSSSSSNSSSSSSSVPTTSNSNTQQSQESVQPLHGLVAGPG-------------YNEFQLQMTDP 189

  Fly   374 RSSSAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRV--GLGTHGVT------GSANLGGSI 430
            |.|::..:.:.|:.            .:.:||:....|.|  |||.....      ..:|:|..:
  Fly   190 RESTSIFMVQPTVS------------VTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNIGAPV 242

  Fly   431 TP---SSDTKPHQCQQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCDRRFKQLSHVQQHTRLHTGE 492
            ..   :.:.|..||..|..||.:...|.:|:|.|...||::||.|.:.|..:..:..|.|:|:||
  Fly   243 MDPALNGNQKCFQCTHCEASFPNAGDLSKHVRSHITNKPFQCSICQKTFTHIGSLNTHIRIHSGE 307

  Fly   493 RPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICGKGFATESSLRTHTSKELQLH 557
            :||||.|  |.:||.|.|:|..|:|:|..:      :|..|..|.|||...|||..|.
  Fly   308 KPYKCEL--CPKAFTQSSSLMVHMRSHSVR------KPHQCVQCDKGFINYSSLLLHQ------- 357

  Fly   558 LGVLQQHAALIGGPNAT-SCPVCHKLFLGTEALVDHMKHVHKEKSPPPGGSASSQFSELNQIVTG 621
                :.|.|    |..| .||.|.:.| ..|||:|....:|
  Fly   358 ----KTHIA----PTETFICPECEREF-KAEALLDEHMRMH------------------------ 389

  Fly   622 NGNGTGSSNEQIATQCTTESNSHQATVGSSLIDSFLGKRRTANHP--CPVCGKHYVNEGSLRKHL 684
                    .:::..||.....:.:|:  |.|:...  |......|  |.:|.:.:...|||..|:
  Fly   390 --------TQELVYQCAICREAFRAS--SELVQHM--KNHMGEKPFTCSLCDRSFTQSGSLNIHM 442

  Fly   685 ACHAENSQLTNSLRMWPCSVCQAVFTHENGLLTHMESMRMDPKHQFAAQY---VLSRAAAEQRE- 745
            ..|...       :.:.|.:|...||..:.|..||:.      |.....|   :..::.::|..
  Fly   443 RIHTGE-------KPFQCKLCDKCFTQASSLSVHMKI------HAGEKPYPCPICGKSYSQQAYL 494

  Fly   746 RESLLAVTLAASSGASTRIGIADAGNVLPTGAHNSDGSNSKCPSPSANSECSSNGRLSSSTTSDQ 810
            .:.:.|..:|:::.|||..|:..|                  ..|.....|...|.|.:..|:
  Fly   495 NKHIQAHQMASAASASTSPGLLVA------------------KQPHETLVCIVCGSLHADATA-- 539

  Fly   811 DQDIDHGLSENENSNQNNIGSSTNNNNNCTSNNNASSHKMAELRLPGTGQYTMDAELHVANRMSL 875
                                              .:||                  :|
  Fly   540 ----------------------------------LASH------------------VH------- 545

  Fly   876 MAAAAAAVAASRPQDGVDTS---AVP----SAAVQAAVVNLAAAM--RMNNSSNGATPYQQHHAD 931
              :..||:..:..|.|::|:   |:|    ||..|.|.|.....:  :||
  Fly   546 --SQHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMN--------------- 593

  Fly   932 HTQAHQTHILQHAHPHHHQQQQAPQHQQQQLSHLLVHTH 970
            |.|.||    ||......||||.||.||||  ||....|
  Fly   594 HQQQHQ----QHQQQPPQQQQQHPQQQQQQ--HLQQQPH 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	30/84 (36%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	454..478	CDD:290200	10/23 (43%)
		C2H2 Zn finger	469..489	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..508	CDD:290200	13/26 (50%)
		C2H2 Zn finger	497..519	CDD:275368	10/21 (48%)
		C2H2 Zn finger	533..557	CDD:275368	9/23 (39%)
		C2H2 Zn finger	576..594	CDD:275368	8/17 (47%)
		C2H2 Zn finger	667..687	CDD:275370	6/19 (32%)
		C2H2 Zn finger	702..719	CDD:275370	5/16 (31%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	62/216 (29%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		zf-H2C2_2	268..293	CDD:290200	10/24 (42%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..321	CDD:290200	13/26 (50%)
		zf-C2H2_2	312..>387	CDD:289522	33/98 (34%)
		C2H2 Zn finger	312..332	CDD:275368	10/21 (48%)
		C2H2 Zn finger	340..360	CDD:275368	9/30 (30%)
		C2H2 Zn finger	369..389	CDD:275368	8/20 (40%)
		C2H2 Zn finger	397..417	CDD:275368	5/23 (22%)
		zf-H2C2_2	409..434	CDD:290200	5/26 (19%)
		C2H2 Zn finger	425..445	CDD:275368	6/19 (32%)
		zf-H2C2_2	437..462	CDD:290200	7/31 (23%)
		C2H2 Zn finger	453..473	CDD:275368	7/25 (28%)
		zf-H2C2_2	465..490	CDD:290200	5/30 (17%)
		C2H2 Zn finger	481..501	CDD:275368	1/19 (5%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100