DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dati and zf30C

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster

Alignment Length:	884	Identity:	169/884 - (19%)
Similarity:	268/884 - (30%)	Gaps:	317/884 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PFGLQTALHQYSSPPNQQPISHHALHHSVPQENEQLAGVQPEGPAAGSGVVGNNSSMAI------ 127
            |...:....::||..|   :|.|.      :......| |||..:.||. .|.....|.
  Fly   131 PMECKCCYTRFSSASN---LSKHR------RSRPDTCG-QPEYDSPGSS-DGMKKHKAFRKKDRN 184

  Fly   128 --SGTNSTVGSKAESS--HIP-----QQHSEQQSYGSDSFRGTQSPQLSSHHLLFNAAAA----- 178
              |....|...::|.|  .||     :...:|:|..|||  |.:.|....::...:|.|:
  Fly   185 RDSDDEDTTSEESEDSDDDIPLASRLKTKLKQESQNSDS--GDECPDFEPNNSEDDADASGFQLP 247

  Fly   179 -------------------AAAAVHLKSTAMQNNLSPIGDQVQNNLRNYGQGSLNALCGIKPKQE 224
                               |:..|..:||.:.:|..   |::.:.|.|.|.       |:||.:.
  Fly   248 PPAMVKVEAFDEEDFEYQDASMYVKTESTDIFSNEK---DKLLDVLLNEGD-------GLKPFES 302

  Fly   225 MDAKTPLQPLDE-CPHPLVQAQAQSQYGGDYYDVADPQAREISEGRALIIGLGAPSTVSTDDAQS 288
            :..:.....||| ...|||             :||:....|:.
  Fly   303 LKVEQGAGILDEIAAVPLV-------------EVAEEDVLELR---------------------- 332

  Fly   289 SAPSHQLAGTGRALQTHQCKPMSPGTVGSSNLGAGRRSAP----TTISKTFSQGQQSPQHSTTPS 349
               .||:.           ||..|          .:|..|    ..:.|...:.:.:|: |.:|.
  Fly   333 ---GHQME-----------KPPGP----------RKRGRPPKEKIPVVKRKYRKRNAPR-SPSPD 372

  Fly   350 GGSTTPDIKYNNDKMANEIQLQLSRSSSAAAISERTLEECWSTLQRLFMHKSAMQQIQQQIPRVG 414
            ..|.||                    ...|.||::.|:|....:.::
  Fly   373 DSSGTP--------------------KRVAKISKKELKERLKMINKM------------------ 399

  Fly   415 LGTHGVTGSANLGGSITPSSDTKPHQCQQCMKSFSSNHQLVQHIRVHTGEKPYKCSYCD------ 473
                                 .|..:|..|:|        :.|||     |||:....|
  Fly   400 ---------------------EKSWKCPHCVK--------IYHIR-----KPYEKHLRDDHKLNE 430

  Fly   474 RRFKQL-SHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPFHCNICG 537
            ...|:: ..|..|.:|  .|..:||  |.|.:.::....|..|::.|....:.....|.:||:.
  Fly   431 AEMKEIFKDVDVHAKL--DEEVFKC--PICSKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLF- 490

  Fly   538 KGFATESSLRTHTSKELQLHLGVLQQHAALIGGPNATSCPVCHKLFLGTEALVDHMKHVHKEKSP 602
              |||:.....|..          .||..|:      .|..|.|...|.::|.:|.::.|.:|.|
  Fly   491 --FATKEQATEHAR----------AQHKELL------YCEKCDKYMTGHDSLKNHERNFHSKKEP 537

  Fly   603 PPGGSASSQFSELNQIVTGNG---NGTGSSNEQIATQCTTESNSHQATVGSSLIDSFLGKRRTAN 664
                    :..:.|.|....|   .|..|.::.:.:.|                      .|...
  Fly   538 --------RSQQRNLICDKCGKKFTGRTSLSDHVRSDC----------------------GRLPL 572

  Fly   665 HPCPVCGKHYVNEGSLRKHLACHAENSQLTNSLRMWPCSVCQAVFTHENGLLTHMESMRMDPKHQ 729
            :.|.|||||....|.|:.|:..|..::.       :.|..|...|..:....:|:::...|.|
  Fly   573 YGCSVCGKHLSTAGILKTHMLLHKADTP-------YQCDKCGKTFKVKAQYKSHLKTRHTDYK-- 628

  Fly   730 FAAQYVLSRAAAEQRERESLLA-------------------VTLAASSGASTRIGIADAGNVLPT 775
               .|.......|...|||||.                   .|..::..|..::. ||....||.
  Fly   629 ---PYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVH-ADTCGQLPL 689

  Fly   776 GAHNSD------GSNSKCPSPSANSECSSNGRLSSSTTSDQDQDIDHGLSENENSNQNNIGSSTN 834
            .|..:.      |.......|.|..|......|.:....|:|..:         :.:.|..|..:
  Fly   690 NAKATQYMGVQRGKLLMGAKPEAGMEYEETKTLIAQDVIDRDMPM---------AQELNFPSDGS 745

  Fly   835 NNNNCTSNNNASSHKMAELRLPGTGQYTMDAELHVANRM 873
            ........|.||:|.:..:.|     .||.||   |.||
  Fly   746 APLATVPLNYASTHLVPHIVL-----QTMQAE---ARRM 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	20/88 (23%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	454..478	CDD:290200	7/29 (24%)
		C2H2 Zn finger	469..489	CDD:275368	4/26 (15%)
		zf-H2C2_2	481..508	CDD:290200	8/26 (31%)
		C2H2 Zn finger	497..519	CDD:275368	5/21 (24%)
		C2H2 Zn finger	533..557	CDD:275368	6/23 (26%)
		C2H2 Zn finger	576..594	CDD:275368	6/17 (35%)
		C2H2 Zn finger	667..687	CDD:275370	9/19 (47%)
		C2H2 Zn finger	702..719	CDD:275370	3/16 (19%)
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368
		C2H2 Zn finger	61..82	CDD:275368
		C2H2 Zn finger	98..117	CDD:275368
		C2H2 Zn finger	134..152	CDD:275368	5/26 (19%)
		C2H2 Zn finger	511..532	CDD:275370	6/20 (30%)
		COG5048	<523..>672	CDD:227381	36/190 (19%)
		C2H2 Zn finger	546..566	CDD:275368	3/19 (16%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	603..624	CDD:275368	4/20 (20%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24409
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100