DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dati and Zfp217

DIOPT Version :9

Sequence 1:	NP_001245421.1	Gene:	dati / 43789	FlyBaseID:	FBgn0262636	Length:	1150	Species:	Drosophila melanogaster
Sequence 2:	NP_001028471.1	Gene:	Zfp217 / 228913	MGIID:	2685408	Length:	1041	Species:	Mus musculus

Alignment Length:	879	Identity:	193/879 - (21%)
Similarity:	284/879 - (32%)	Gaps:	287/879 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 PHQCQQCMKSFS-----SNHQLVQH---------IRVH--------------------TGEKP-- 466
            |..|..|.:.||     |.|.|:||         :||.                    :||.|
Mouse    56 PLDCMFCSQVFSQAEDLSQHVLLQHRPTLCEPAVLRVEAEYLSPLDKALEPTEPALEKSGEDPEE 120

  Fly   467 YKCSYCDRRFKQLSHVQQHTRLHTGERPYKCHLPDCGRAFIQLSNLQQHLRNHDAQVERAKNRPF 531
            ..|..|.:.|.....|:.|.:.|.....|.|.:  |||.|.:...|:.|:|.|:
Mouse   121 LSCDVCGQTFPVAFDVESHMKKHKDSFTYGCSM--CGRRFKEPWFLKNHMRTHN----------- 172

  Fly   532 HCNICGKGFATESSLRTHTSKELQLHLGVLQQHAALIGGPNATS-----CPVCHKLFLGTEALVD 591
                 ||. .|.|.|:......:.:: .|:|.||     |.:.|     |.||..||...::|::
Mouse   173 -----GKS-GTRSKLQQGMESPVTIN-EVVQPHA-----PGSISTPYKICMVCGFLFPNKQSLIE 225

  Fly   592 HMKHVHKEKSPPPGGSA---------SSQFSELNQIVTGNGNGTGSSNE---------------- 631
            |.| ||.:::.|...:.         :|...||.|.:......|..|..
Mouse   226 HSK-VHAKETVPSASNVAPDDHREEPTSPREELLQFLNLRPRSTAGSTVKPMTCIPQLDPFTTYQ 289

  Fly   632 --QIATQ------------------------CTTESNSHQATVGSSLIDSFLGKRRTANHPCPVC 670
              |:||:                        |:.:....:..||.....|  ||.:|:...||..
Mouse   290 AWQLATKGKVAVAQEEVKESGQEGSTDNDDSCSEKEELGEIWVGGKAEGS--GKSKTSKSSCPGL 352

  Fly   671 GKHYVNEGSLRKHLACHAENSQL--------TNSLRMWP--CSVCQAVFTHENGLLTHMESMRMD 725
                    |..|....|| ||::        .:|.:..|  ||.|...|...:.|:.|....|.|
Mouse   353 --------SQDKEKPRHA-NSEVPSGDSDPKLSSSKEKPTHCSECSKAFRTYHQLVLHSRVHRKD 408

  Fly   726 PKHQFAAQYVLSRAAAEQRERESLLAVTLAAS---SGASTRIGIADAGNV--LPTGAH---NSDG 782
            .:..     .||...|....:....:..|:.:   |||..|.|.::.|:.  ||.|.|   |.||
Mouse   409 RRTD-----ALSPTMAVDARQPGTCSPDLSTTLEDSGAGDREGGSEDGSEDGLPDGLHLDKNDDG 468

  Fly   783 SNSKCPSPSANSECSSNGRLSSSTTSDQDQDIDHGLSENENSNQNNIGSSTNNNN---NCTSNNN 844
            ..:| |.||:. |||..|:...|                  :...||...|:...   .|.....
Mouse   469 GKAK-PLPSSR-ECSYCGKFFRS------------------NYYLNIHLRTHTGEKPYKCEFCEY 513

  Fly   845 ASSHKMAELRLPGTGQYTMDAELHVANRMSLMAAAAAAV--AASRPQDGVDTSAVPSAAVQAAVV 907
            |::.| ..||      |.:  |.|..::..:.|||.:..  .:..|||     |:.:||..|...
Mouse   514 AAAQK-TSLR------YHL--ERHHKDKQPVDAAAESKSEGRSQEPQD-----ALLTAADSAQTK 564

  Fly   908 NLAAAMRMNNSSNGATPYQQHHADHTQAHQTHILQHAHPHHHQQQQAPQHQQQQLSHLLVHTHPS 972
            ||...:.......|:.|.:|             |:.. |...|...:|.|......   .|.|.:
Mouse   565 NLKRFLDGAKDVKGSPPAKQ-------------LKEM-PSVFQSVLSPAHSNDTQD---FHKHAA 612

  Fly   973 NSNSRSQSSPNINVPSLQNEST--------------AASIAMNMNVHMMRGSLDPDP-------- 1015
            :|..:::.||......:|.:..              ..|:|.... |  |..:|.|.
Mouse   613 DSAEKARKSPAPTYLDMQRKKAGEPQASSPVCRLEGVGSLAREAG-H--REKMDQDADYRHKPGA 674

  Fly  1016 ---------SLGGMHGI-------------------------EVLHQHQQQHHHHHHHHTSNYPQ 1046
                     |||.:|..                         |||..||:..|.::.....|...
Mouse   675 DCQDRPLNLSLGPLHACPAISLSKCLIPSIACPFCTFKTFYPEVLMMHQRLEHRYNPDPHKNGSS 739

  Fly  1047 HAVTPTNQHTHPHPQ------THQTAHHHTSPETALRMHQAEAILRSHTEAAFRLATG------- 1098
            .:|. .|:.|...|.      ...:..|....:||...|....    |:|.|.:.|:|
Mouse   740 KSVL-RNRRTGCPPALLGKDVPPLSGLHKPKAKTAFSPHSKSL----HSEKARQGASGPSKAPQT 799

  Fly  1099 SGPDTGVKCEADQNQLNSNNAGNAGGNSGGNSQQ 1132
            ||||....  |..|..:..:..||||.|....||
Mouse   800 SGPDNSTL--APSNLKSHRSQPNAGGTSATRQQQ 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dati	NP_001245421.1	COG5048	<429..>511	CDD:227381	27/108 (25%)
		C2H2 Zn finger	441..461	CDD:275368	10/33 (30%)
		zf-H2C2_2	454..478	CDD:290200	11/54 (20%)
		C2H2 Zn finger	469..489	CDD:275368	5/19 (26%)
		zf-H2C2_2	481..508	CDD:290200	9/26 (35%)
		C2H2 Zn finger	497..519	CDD:275368	8/21 (38%)
		C2H2 Zn finger	533..557	CDD:275368	5/23 (22%)
		C2H2 Zn finger	576..594	CDD:275368	7/17 (41%)
		C2H2 Zn finger	667..687	CDD:275370	4/19 (21%)
		C2H2 Zn finger	702..719	CDD:275370	5/16 (31%)
Zfp217	NP_001028471.1	C2H2 Zn finger	59..80	CDD:275368	7/20 (35%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	151..171	CDD:275368	8/21 (38%)
		zf-C2H2	151..171	CDD:395048	8/21 (38%)
		C2H2 Zn finger	210..230	CDD:275368	8/20 (40%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-C2H2	479..500	CDD:395048	7/38 (18%)
		C2H2 Zn finger	480..500	CDD:275370	6/37 (16%)
		zf-H2C2_2	492..517	CDD:404364	5/24 (21%)
		zf-H2C2_5	506..530	CDD:404746	8/32 (25%)
		C2H2 Zn finger	508..529	CDD:275370	7/29 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000