DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and PMD1

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_011058.3 Gene:PMD1 / 856869 SGDID:S000000934 Length:1753 Species:Saccharomyces cerevisiae


Alignment Length:1795 Identity:325/1795 - (18%)
Similarity:576/1795 - (32%) Gaps:630/1795 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 KELMVVFGGGNEGIVD----------ELHVYNTVTNQW------YVPVLKGDVPNGCA-----AY 126
            |||::.||...:...|          |:...:.::..|      .....:.::.||.:     .:
Yeast    71 KELILYFGKQKDRNADFKTLADWISPEIFFLDLISRTWQRINTTIDTTSENELNNGLSFKERLFH 135

  Fly   127 GFVVEGTRMFVFGGMI--EYGKY----SNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTM 185
            ......:.:::|||::  .:..|    :|||::|......| .:..|:|..    ..|..||..:
Yeast   136 SMCFTESNIYIFGGLMVSPHNGYELIATNELWKLDLKTKCW-SLISENPQI----TRRFNHSMHV 195

  Fly   186 VGE-------KIFLFGGLAN--------------------ESDDPKNNIPKYLNDLYI-LDTRGV 222
            :.|       |:.:.|||.|                    ||...:|...|..:.:.: :|...:
Yeast   196 LNENNENQDTKLIIVGGLDNMDIPVKKIDIFNLRTSLWESESKSDENPASKGSSKILVNIDGMPI 260

  Fly   223 ---HSHNGKWIVPKTYGDSP------PPRESHTGI------SFAT-------KS---------NG 256
               |..|...::.....:.|      |.||::|..      ||:|       ||         :|
Yeast   261 SLSHDSNFSVLIENNQAEIPTLALYYPQREANTSRRGTDDGSFSTYAHDLDDKSKLPKHHHHHHG 325

  Fly   257 NLN---------------------LLIYGGMSGCRLGDLWLLETDSMTWSKPKT----------- 289
            :|.                     |.:.|...|.|:       |.:.|.:..:.           
Yeast   326 DLKYFESDDADENAVKTLMSPIVILPLLGNSQGARM-------TSNPTQNNKENSILQVPFHLQY 383

  Fly   290 -SGE-------------APLPRSLHSSTMIGNKMYVF----GGW--VPLVINDSKSTTEREWKCT 334
             ||.             .|.|.:||        .:::    |.|  |.:...:...:..|.||  
Yeast   384 PSGNYFNYNIVVIGFYPDPQPSNLH--------CFIYNIASGKWIRVNIACTECSISMHRFWK-- 438

  Fly   335 NTLAVLDLETMTWEN----VTLDTVEENVPRARAGHCAVGIQSRLYVWSGR----DGYRKAWNNQ 391
                     .:.|::    :.|.|..::       .|:..:|...::.|..    :||.|..|.:
Yeast   439 ---------LLIWKSHHQALLLGTRTDD-------FCSPSVQKFDHILSFSLPMLNGYNKLVNTK 487

  Fly   392 VCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNN- 455
                   :...:..:         |::|.|.::.:...            ..|.:.||.:...| 
Yeast   488 -------HTRTNNGI---------ANSHNLNVNLSLYD------------HLPYSNSSTIEHTNP 524

  Fly   456 -IVQQGTPTSAETSGINISANRSGS---------ALGLGVEATSTV-----LKLEKESLQLSGCQ 505
             .|.||  .|.:.|||....:.:.|         .:.|.:|:||::     :.|.|::|::.|  
Yeast   525 YTVTQG--YSLDDSGIPRLTSTATSQFENYSRYITVPLEMESTSSIFPPYAMVLGKDALEIFG-- 585

  Fly   506 PETNVQPSVNDLLQSMSQPSS---PASRADK------DPLSSGG--GTTFNL-----STSVASVH 554
                  .:::|.....:...|   |.....|      |.|.|.|  .|:||.     ::::.|..
Yeast   586 ------KTLSDFEFITADGDSIGVPVYLLRKRWGRYFDSLLSNGYANTSFNYEFNGDTSNIISFS 644

  Fly   555 PQISVISSTAAVT---GNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPS 616
            |.      ||:.|   ||.:.|.:|::.....|          :..:..:..||...|.||...|
Yeast   645 PH------TASKTTKFGNSSQSSNGSLEKYFSK----------NGNSKSNSNTSLKKPHSVDFTS 693

  Fly   617 TMSANVVLSSSSSTLRIVP--SVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTS 679
                    |:||...|.:.  .::.|..:..|..:.|.:|.....|..  .|.|......::...
Yeast   694 --------STSSPKQRAISHNKLSPSEPILCADEEDSRSNTLKQHATG--DTGLKETGTSNKRPI 748

  Fly   680 STTTSIGGKQYFIQKPLTLAPNVQLQFVKTSG------------------------GMTVQTLPK 720
            |||.|..|..:.:  |.....|.:|...:.||                        ..|:...|.
Yeast   749 STTCSSTGMVFRV--PFQDMKNSKLGLSEQSGRSTRASSVSPPPVYKKSTNDGNDSNCTLSNTPL 811

  Fly   721 VNFTASK-GTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMK 784
            |...||. ||      ..|..:..|.:.|:.::.|   :|..|::.:....:|..:.|......:
Yeast   812 VYRRASTVGT------TTNSSVDDGFSSIRRASHP---LQSYIIAKSSPSSISKASPAEKAFSRR 867

  Fly   785 NSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTN 849
            .|:.|:              |:     .:|..::|....:|..      |::|::|..|....:|
Yeast   868 KSSALR--------------FI-----ASPNQSRQTSFASTAS------TASVVSSTSGRRRNSN 907

  Fly   850 IVSIVNSTSTTPS-----------------PLQAL------------------------------ 867
            .:|.:.|:::.|:                 ||:.|                              
Yeast   908 QISHLGSSASLPNSPILPVLNIPLPPQEKIPLEPLPPVPKAPSRRSSSLAEYVQFGRDSPVASRR 972

  Fly   868 ---------SGQKTLISNQSGVKMLRNISSVQASSS----------------MAFGQKQSGTPIH 907
                     |.....|||.|   :|||....|..|:                |..|:.:.....:
Yeast   973 SSHSTRKSSSSDARRISNSS---LLRNTLDSQLLSNSYGSDIPYEASIQEYGMNNGRDEEEDGDN 1034

  Fly   908 QKTALYIGGKAVTVMSTNTSMAASGN---------KVMV----------------LPGTSSNNS- 946
            |............:.||..::..:||         |..:                :..|:|||: 
Yeast  1035 QDYGCISPSNIRPIFSTINAININGNFKEGEFFSSKSYINNEKSRRLSYISNPESVESTNSNNNA 1099

  Fly   947 ---------------PATTTALSARKSFVFNA--GG----SPRTVTLAT---------------- 974
                           |.:|.::.|...|.:.|  .|    :|.|:.|..                
Yeast  1100 IIELEPLLTPRSLYMPWSTASVRAFAEFFYTAQINGKWLLAPVTLDLLIMAKIYEIPILYELITE 1164

  Fly   975 ---KSINAKSIPQS-----------QPVTETNNHSVATIK----DTDPMDDIIE------QLDG- 1014
               |.|:.|....|           |.|:...|.:...|:    .::...|.:|      .:|. 
Yeast  1165 VLYKIISKKEEGLSVTCEALLNLFQQKVSRYCNENEGKIRKQLDSSESYQDTLEIKRSLANIDNG 1229

  Fly  1015 -AGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTA----------GPSRAQNPI-VME 1067
             ....|..:.|..|.....:::|||.......:.:.:.|..|          ||..:.|.| .:.
Yeast  1230 YVDSYLLRNTSMAQSIHYTDDSNGETEIDMHHTGISSIGSLANRAVPTVFAGGPRDSHNSIGSIA 1294

  Fly  1068 HP-----VDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTT 1127
            .|     .:|...||..|..|  .:.:.:|.:| :.|..|::..|||...|.   :|...:.|..
Yeast  1295 FPSNSGVQNIRRSVSLFSPAT--KKKSSLSRET-DPLDTSDQFTDDVPDSGP---VSRQQNFPRR 1353

  Fly  1128 SETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNV 1192
            |.:...|:            .|...|.::.  .:.|.|.|:..:.|.:|.::::    :....|.
Yeast  1354 SSSFTETV------------PTEPTRYNYQ--NLDSSKSNRASDDKEEQNEQAT----LQDISNF 1400

  Fly  1193 DGSQLEALASAALLQAATSDTTALALKEL-IERPESETN------------TRSSNIAEIQQNNV 1244
            |..::|.|...........|.|...||.. .|.|::.:|            :.|.:......:::
Yeast  1401 DKYKVETLQKRNSNDGKDLDRTNDPLKNRGTEIPQNSSNLETDPFIRDSFDSDSGSSFRSDSDDL 1465

  Fly  1245 QSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKF--PRT 1307
            .|.|. ::|.|..|:..:..|...|.| |......|.|:....|...|       .|||:  |.:
Yeast  1466 DSQLG-ILPFTKMNKKLQEQTSQEFDD-SIDPLYKIGSSTPGSSRLHG-------SFSKYIRPNS 1521

  Fly  1308 NLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGA-PSAIKISKDVKEGAHLTWEPPPAQK 1371
            ..|.|:.|      :|         |||.:..:.  |.| |....:.|.:...:.|..:.....:
Yeast  1522 QREDGSEY------VN---------ISSLENMVS--PNALPPVDYVMKSIYRTSVLVNDSNLMTR 1569

  Fly  1372 TKEIIEYSVYLAVKPTAK----------DKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDC- 1425
            |||.||.|..|  |...|          |:...|.:..|.|   |::      :.:||..|.|. 
Yeast  1570 TKEAIELSKVL--KKLKKKVLQDISQMDDEMRETGKPIFAR---GSS------SPTLSRQHSDVA 1623

  Fly  1426 -------SNKPAIIFRIAARNQKGY---------GPATQV 1449
                   :.:||:.|..::...:|:         .|:||:
Yeast  1624 TPLKQQENTRPALKFASSSPISEGFRKSSIKFSQAPSTQI 1663

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 7/36 (19%)
KELCH repeat 74..115 CDD:276965 8/47 (17%)
KELCH repeat 123..175 CDD:276965 11/62 (18%)
Kelch_3 132..184 CDD:290151 14/57 (25%)
Kelch_5 175..221 CDD:290565 14/73 (19%)
KELCH repeat 178..239 CDD:276965 16/91 (18%)
Kelch_3 260..305 CDD:290151 12/69 (17%)
KELCH repeat 297..360 CDD:276965 11/72 (15%)
Kelch_3 306..371 CDD:290151 10/74 (14%)
FN3 <1307..1338 CDD:238020 7/30 (23%)
FN3 1344..1448 CDD:238020 28/131 (21%)
PMD1NP_011058.3 Kelch_6 132..188 CDD:404790 11/60 (18%)
KELCH repeat 132..184 CDD:276965 10/52 (19%)
KELCH repeat 188..235 CDD:276965 9/46 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343272
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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