Protein Alignment Hcf and PMD1

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_011058.3
• Gene: PMD1 / 856869
• SGDID: S000000934
• Length: 1753
• Species: Saccharomyces cerevisiae
• Alignment Length: 1795
• Identity: 325/1795 - (18%)
• Similarity: 576/1795 - (32%)
• Gaps: 630/1795 - (35%)

  Fly    83 KELMVVFGGGNEGIVD----------ELHVYNTVTNQW------YVPVLKGDVPNGCA-----AY 126
            |||::.||...:...|          |:...:.::..|      .....:.::.||.:     .:
Yeast    71 KELILYFGKQKDRNADFKTLADWISPEIFFLDLISRTWQRINTTIDTTSENELNNGLSFKERLFH 135

  Fly   127 GFVVEGTRMFVFGGMI--EYGKY----SNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTM 185
            ......:.:::|||::  .:..|    :|||::|......| .:..|:|..    ..|..||..:
Yeast   136 SMCFTESNIYIFGGLMVSPHNGYELIATNELWKLDLKTKCW-SLISENPQI----TRRFNHSMHV 195

  Fly   186 VGE-------KIFLFGGLAN--------------------ESDDPKNNIPKYLNDLYI-LDTRGV 222
            :.|       |:.:.|||.|                    ||...:|...|..:.:.: :|...:
Yeast   196 LNENNENQDTKLIIVGGLDNMDIPVKKIDIFNLRTSLWESESKSDENPASKGSSKILVNIDGMPI 260

  Fly   223 ---HSHNGKWIVPKTYGDSP------PPRESHTGI------SFAT-------KS---------NG 256
               |..|...::.....:.|      |.||::|..      ||:|       ||         :|
Yeast   261 SLSHDSNFSVLIENNQAEIPTLALYYPQREANTSRRGTDDGSFSTYAHDLDDKSKLPKHHHHHHG 325

  Fly   257 NLN---------------------LLIYGGMSGCRLGDLWLLETDSMTWSKPKT----------- 289
            :|.                     |.:.|...|.|:       |.:.|.:..:.
Yeast   326 DLKYFESDDADENAVKTLMSPIVILPLLGNSQGARM-------TSNPTQNNKENSILQVPFHLQY 383

  Fly   290 -SGE-------------APLPRSLHSSTMIGNKMYVF----GGW--VPLVINDSKSTTEREWKCT 334
             ||.             .|.|.:||        .:::    |.|  |.:...:...:..|.||
Yeast   384 PSGNYFNYNIVVIGFYPDPQPSNLH--------CFIYNIASGKWIRVNIACTECSISMHRFWK-- 438

  Fly   335 NTLAVLDLETMTWEN----VTLDTVEENVPRARAGHCAVGIQSRLYVWSGR----DGYRKAWNNQ 391
                     .:.|::    :.|.|..::       .|:..:|...::.|..    :||.|..|.:
Yeast   439 ---------LLIWKSHHQALLLGTRTDD-------FCSPSVQKFDHILSFSLPMLNGYNKLVNTK 487

  Fly   392 VCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNN- 455
                   :...:..:         |::|.|.::.:...            ..|.:.||.:...|
Yeast   488 -------HTRTNNGI---------ANSHNLNVNLSLYD------------HLPYSNSSTIEHTNP 524

  Fly   456 -IVQQGTPTSAETSGINISANRSGS---------ALGLGVEATSTV-----LKLEKESLQLSGCQ 505
             .|.||  .|.:.|||....:.:.|         .:.|.:|:||::     :.|.|::|::.|
Yeast   525 YTVTQG--YSLDDSGIPRLTSTATSQFENYSRYITVPLEMESTSSIFPPYAMVLGKDALEIFG-- 585

  Fly   506 PETNVQPSVNDLLQSMSQPSS---PASRADK------DPLSSGG--GTTFNL-----STSVASVH 554
                  .:::|.....:...|   |.....|      |.|.|.|  .|:||.     ::::.|..
Yeast   586 ------KTLSDFEFITADGDSIGVPVYLLRKRWGRYFDSLLSNGYANTSFNYEFNGDTSNIISFS 644

  Fly   555 PQISVISSTAAVT---GNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPS 616
            |.      ||:.|   ||.:.|.:|::.....|          :..:..:..||...|.||...|
Yeast   645 PH------TASKTTKFGNSSQSSNGSLEKYFSK----------NGNSKSNSNTSLKKPHSVDFTS 693

  Fly   617 TMSANVVLSSSSSTLRIVP--SVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTS 679
                    |:||...|.:.  .::.|..:..|..:.|.:|.....|..  .|.|......::...
Yeast   694 --------STSSPKQRAISHNKLSPSEPILCADEEDSRSNTLKQHATG--DTGLKETGTSNKRPI 748

  Fly   680 STTTSIGGKQYFIQKPLTLAPNVQLQFVKTSG------------------------GMTVQTLPK 720
            |||.|..|..:.:  |.....|.:|...:.||                        ..|:...|.
Yeast   749 STTCSSTGMVFRV--PFQDMKNSKLGLSEQSGRSTRASSVSPPPVYKKSTNDGNDSNCTLSNTPL 811

  Fly   721 VNFTASK-GTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMK 784
            |...||. ||      ..|..:..|.:.|:.::.|   :|..|::.:....:|..:.|......:
Yeast   812 VYRRASTVGT------TTNSSVDDGFSSIRRASHP---LQSYIIAKSSPSSISKASPAEKAFSRR 867

  Fly   785 NSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTN 849
            .|:.|:              |:     .:|..::|....:|..      |::|::|..|....:|
Yeast   868 KSSALR--------------FI-----ASPNQSRQTSFASTAS------TASVVSSTSGRRRNSN 907

  Fly   850 IVSIVNSTSTTPS-----------------PLQAL------------------------------ 867
            .:|.:.|:::.|:                 ||:.|
Yeast   908 QISHLGSSASLPNSPILPVLNIPLPPQEKIPLEPLPPVPKAPSRRSSSLAEYVQFGRDSPVASRR 972

  Fly   868 ---------SGQKTLISNQSGVKMLRNISSVQASSS----------------MAFGQKQSGTPIH 907
                     |.....|||.|   :|||....|..|:                |..|:.:.....:
Yeast   973 SSHSTRKSSSSDARRISNSS---LLRNTLDSQLLSNSYGSDIPYEASIQEYGMNNGRDEEEDGDN 1034

  Fly   908 QKTALYIGGKAVTVMSTNTSMAASGN---------KVMV----------------LPGTSSNNS- 946
            |............:.||..::..:||         |..:                :..|:|||:
Yeast  1035 QDYGCISPSNIRPIFSTINAININGNFKEGEFFSSKSYINNEKSRRLSYISNPESVESTNSNNNA 1099

  Fly   947 ---------------PATTTALSARKSFVFNA--GG----SPRTVTLAT---------------- 974
                           |.:|.::.|...|.:.|  .|    :|.|:.|..
Yeast  1100 IIELEPLLTPRSLYMPWSTASVRAFAEFFYTAQINGKWLLAPVTLDLLIMAKIYEIPILYELITE 1164

  Fly   975 ---KSINAKSIPQS-----------QPVTETNNHSVATIK----DTDPMDDIIE------QLDG- 1014
               |.|:.|....|           |.|:...|.:...|:    .::...|.:|      .:|.
Yeast  1165 VLYKIISKKEEGLSVTCEALLNLFQQKVSRYCNENEGKIRKQLDSSESYQDTLEIKRSLANIDNG 1229

  Fly  1015 -AGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTA----------GPSRAQNPI-VME 1067
             ....|..:.|..|.....:::|||.......:.:.:.|..|          ||..:.|.| .:.
Yeast  1230 YVDSYLLRNTSMAQSIHYTDDSNGETEIDMHHTGISSIGSLANRAVPTVFAGGPRDSHNSIGSIA 1294

  Fly  1068 HP-----VDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTT 1127
            .|     .:|...||..|..|  .:.:.:|.:| :.|..|::..|||...|.   :|...:.|..
Yeast  1295 FPSNSGVQNIRRSVSLFSPAT--KKKSSLSRET-DPLDTSDQFTDDVPDSGP---VSRQQNFPRR 1353

  Fly  1128 SETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNV 1192
            |.:...|:            .|...|.::.  .:.|.|.|:..:.|.:|.::::    :....|.
Yeast  1354 SSSFTETV------------PTEPTRYNYQ--NLDSSKSNRASDDKEEQNEQAT----LQDISNF 1400

  Fly  1193 DGSQLEALASAALLQAATSDTTALALKEL-IERPESETN------------TRSSNIAEIQQNNV 1244
            |..::|.|...........|.|...||.. .|.|::.:|            :.|.:......:::
Yeast  1401 DKYKVETLQKRNSNDGKDLDRTNDPLKNRGTEIPQNSSNLETDPFIRDSFDSDSGSSFRSDSDDL 1465

  Fly  1245 QSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYIDSNCISDSFFDGIDVDNLPDFSKF--PRT 1307
            .|.|. ::|.|..|:..:..|...|.| |......|.|:....|...|       .|||:  |.:
Yeast  1466 DSQLG-ILPFTKMNKKLQEQTSQEFDD-SIDPLYKIGSSTPGSSRLHG-------SFSKYIRPNS 1521

  Fly  1308 NLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGA-PSAIKISKDVKEGAHLTWEPPPAQK 1371
            ..|.|:.|      :|         |||.:..:.  |.| |....:.|.:...:.|..:.....:
Yeast  1522 QREDGSEY------VN---------ISSLENMVS--PNALPPVDYVMKSIYRTSVLVNDSNLMTR 1569

  Fly  1372 TKEIIEYSVYLAVKPTAK----------DKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDC- 1425
            |||.||.|..|  |...|          |:...|.:..|.|   |::      :.:||..|.|.
Yeast  1570 TKEAIELSKVL--KKLKKKVLQDISQMDDEMRETGKPIFAR---GSS------SPTLSRQHSDVA 1623

  Fly  1426 -------SNKPAIIFRIAARNQKGY---------GPATQV 1449
                   :.:||:.|..::...:|:         .|:||:
Yeast  1624 TPLKQQENTRPALKFASSSPISEGFRKSSIKFSQAPSTQI 1663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	70/421 (17%)
		KELCH repeat	74..115	CDD:276965	8/47 (17%)
		KELCH repeat	123..175	CDD:276965	11/62 (18%)
		KELCH repeat	178..239	CDD:276965	16/91 (18%)
		KELCH repeat	297..360	CDD:276965	11/72 (15%)
		FN3	<1307..>1381	CDD:442628	18/74 (24%)
		FN3	<1307..1338	CDD:238020	7/30 (23%)
		FN3	1344..1448	CDD:238020	28/131 (21%)
PMD1	NP_011058.3	Kelch_6	132..188	CDD:404790	11/60 (18%)
		KELCH repeat	132..184	CDD:276965	10/52 (19%)
		KELCH repeat	188..235	CDD:276965	9/46 (20%)