DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and MDS3

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_011318.2 Gene:MDS3 / 852678 SGDID:S000003165 Length:1487 Species:Saccharomyces cerevisiae


Alignment Length:1258 Identity:229/1258 - (18%)
Similarity:400/1258 - (31%) Gaps:431/1258 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   178 RLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPR 242
            |.|.:.|:....||:.|||....:.|..|..:...:|.:...                      :
Yeast    41 RTGSAVTLTRSNIFVHGGLTIPLNLPVVNSMQLQKELILFFA----------------------K 83

  Fly   243 ESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSG---------------- 291
            |.:.|.||.     |||..|        ..:.:.|:..|.||.:.|||.                
Yeast    84 EKNNGSSFR-----NLNEWI--------SKETFFLDLMSRTWYRVKTSFDQRTEELLKAESSSAK 135

  Fly   292 ------------------EAPL-PRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTL 337
                              |:|| .|..||...:...:|:|||   |.::....   .|...||.|
Yeast   136 ADNDTNEIRTDIKKGKSLESPLKERLFHSLCYLDGCLYIFGG---LTVSPQSG---YELIATNEL 194

  Fly   338 AVLDLETMTWE------------NVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGY------ 384
            ..|||.|..|.            |.|:....||....         .::|.:..|.:..      
Yeast   195 WKLDLNTKKWSLLSDDPQIARRFNHTMHVKNENNDNR---------DTKLIIVGGLNNMDQPVKK 250

  Fly   385 -------RKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALEL-SWTATTFAAAYVLQIQKI 441
                   :..|.::...|.  .:|::..:..:.:||.:....::.: :..|...|.|:.::..:|
Yeast   251 IDIYNISQNCWQSETIPKQ--PMEITTNVNGIPLALSKDQNFSILVENNEANVPALAFYMRSDQI 313

  Fly   442 EQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQP 506
            ::.|...|..:..|......|..:|:.||.:.:|.:                |.|:.|.:    |
Yeast   314 DEYLGKDSSKIKENSPIVALPLLSESQGIRMPSNPA----------------LPKKLLNV----P 358

  Fly   507 ETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAV----T 567
            ...:.|:                           |..|..:..:...||.....:....:    :
Yeast   359 YELLAPT---------------------------GDYFGFNIIIGGFHPNYQSSNFHCFIYDINS 396

  Fly   568 GN----DTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSS 628
            |.    .||.|...||    |.|.....|..|....:.:.|.|.|..|                 
Yeast   397 GKWSRVATACPDCDIN----KHRFWRVFVWKSHHQTILLGTKTDDYYS----------------- 440

  Fly   629 STLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKT-ALPNVAVQSQPTSSTTTSIGGKQYFI 692
                  |||                     ...:.|.| .||.|.:.::                
Yeast   441 ------PSV---------------------QRFDHLSTFGLPLVNIFNK---------------- 462

  Fly   693 QKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQ 757
                    .:||...|.|....  .:|..||...|.||...:|..    :|..:|.:...   ..
Yeast   463 --------TIQLPHHKISASSL--PIPIENFAKHKDTPLKKVSFT----SSATSQFENYI---RY 510

  Fly   758 IQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIII 822
            |..|:...::..:..|:.|..||      :.|::                   .|.||.:.:.| 
Yeast   511 IAPPLEMSSIQSVFPPYAMVLGK------DALEI-------------------YGKPLSDFEFI- 549

  Fly   823 VTTGGNVRSVPTSTVMTSAGG------SASGTNIVSIVNSTSTTPSPLQALSGQKTLI-----SN 876
             |:.|:...:|...:....|.      |.|.|.:.:...:|.|          |.|||     |:
Yeast   550 -TSEGDSIGIPCYLLRKRWGRYFDMLLSQSYTKVCADYETTDT----------QSTLIKFSPHSS 603

  Fly   877 QSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGT 941
            ::..|.:|....:.:|.|:. ...:...||..:|::      ....:|...:|.:..|....|.|
Yeast   604 RNSSKAVRQEGRLSSSGSLD-NYFEKNFPIFARTSV------SEAQNTQPQVANADAKAPNTPST 661

  Fly   942 SSNNSPATTTALSARKSFVFNAGG-------SPRTVTLA---------TKSINAKS--------I 982
            |...|.::::.|.:...:..|...       ||:.|:.:         |:|.:..|        :
Yeast   662 SDEPSSSSSSDLYSTPHYQRNNDEEDDEDPVSPKPVSKSNSIYRPIRKTESSSTTSSSNGMIFRV 726

  Fly   983 PQSQPVTETNNHSVATIKDTDPMDDIIEQLDG-----AGDLLKLSESEGQHGSEENENNGENATS 1042
            |..:....|:| :.|.::....:.::..:...     :|:||:.|.||.:|     :....:..:
Yeast   727 PFKEKAAVTSN-TEALLESNLSLQELSRRRSSLMSIPSGELLRSSISEAEH-----QRRASHPLT 785

  Fly  1043 SSASALFTGGDTAGPSRAQNPIVMEHPV--------------DIIEDVSGVSSTTDVNETAIVSG 1093
            |  |.||.  |:..|...|...:.:|.:              .....:|.|||::|..      |
Yeast   786 S--SPLFE--DSGTPCGKQLQQLQQHTIQNPHNHLSPRRFSRSARSSISYVSSSSDRR------G 840

  Fly  1094 DTIESLKMSEKENDDVKSMGEKSIL----------SDDCHQP--------TTSETEAATILTT-I 1139
            ::|.|...|:       |.|...:|          :.:.::|        |.|.|..:..||. :
Yeast   841 NSISSRSTSD-------SFGTPPVLGVLNVPLPPQTREPNEPPPPCPAMSTGSNTRRSNTLTDYM 898

  Fly  1140 KSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSP-SQNIHQF---QNVDGSQLEAL 1200
            .|.:|....:.  |..|.|                  |:.|:| ::|....   .::||..|   
Yeast   899 HSNKASPFSSR--RSSHIG------------------RRSSTPETENAFSATPRASLDGQML--- 940

  Fly  1201 ASAALLQAATSDTTALAL------KELIERPESETN--TRSSNIAEIQQ-NNVQSTLAVVVPN-- 1254
             ..:|.:.:||..|...:      .|.|:.|.|..|  :|.|..:.... :::||..|:.:..  
Yeast   941 -GKSLKEGSTSQYTQPRMNSFPKANETIQTPTSSNNEWSRQSVTSNTDSFDSLQSNFALELEPLL 1004

  Fly  1255 TSQNENQKW--HTVGVFKDLSHT 1275
            |.::....|  .||..|.:..:|
Yeast  1005 TPRSLYMPWPTSTVRAFAEFFYT 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660
KELCH repeat 74..115 CDD:276965
KELCH repeat 123..175 CDD:276965
Kelch_3 132..184 CDD:290151 2/5 (40%)
Kelch_5 175..221 CDD:290565 11/42 (26%)
KELCH repeat 178..239 CDD:276965 11/60 (18%)
Kelch_3 260..305 CDD:290151 14/79 (18%)
KELCH repeat 297..360 CDD:276965 21/74 (28%)
Kelch_3 306..371 CDD:290151 18/76 (24%)
FN3 <1307..1338 CDD:238020
FN3 1344..1448 CDD:238020
MDS3NP_011318.2 PHA03098 <139..261 CDD:222983 26/136 (19%)
KELCH repeat 160..210 CDD:276965 17/55 (31%)
Kelch_3 169..221 CDD:404319 15/57 (26%)
KELCH repeat 216..263 CDD:276965 7/55 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343271
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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