DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcf and Hcfc2

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_030101101.1	Gene:	Hcfc2 / 67933	MGIID:	1915183	Length:	788	Species:	Mus musculus

Alignment Length:	1403	Identity:	367/1403 - (26%)
Similarity:	498/1403 - (35%)	Gaps:	708/1403 - (50%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCA 124
            |:||.:.|||.||.||||||:.|:|||::||||||||.|||||||||||||::|.::||:|.|||
Mouse     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTVTNQWFLPAVRGDIPPGCA 73

  Fly   125 AYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEK 189
            |:|||.:|||:.|||||:|||:||||||||||::|.|:|:.|:.|.||..|||||||||::.|.|
Mouse    74 AHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPQPPPSGFPPCPRLGHSFSLYGNK 138

  Fly   190 IFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISFA 251
            .:|||||||||:|..||:|:||||.|.|:.:   ||..    |.:|.|.|..|.||||||.|.:.
Mouse   139 CYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVG----WSIPATKGVVPSPRESHTAIIYC 199

  Fly   252 TKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWV 316
            .|.:.:..:.::|||.|.||.|||.|:.::|:||||:|.|..|||||||::::||||||:|||||
Mouse   200 KKDSASPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWV 264

  Fly   317 P-LVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEE---NVPRARAGHCAVGIQSRLYV 377
            | ...|...|..:.||:||::.:.|:|:|..|..:..|:.|:   :.||.|||||||.|.:|||.
Mouse   265 PHKGENPETSPHDCEWRCTSSFSYLNLDTAEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYF 329

  Fly   378 WSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIE 442
            |||||||:||.|:||||||||||:..||....:|.|::|:|::..:.|........|:||
Mouse   330 WSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVPTVEGYLLQ----- 389

  Fly   443 QPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPE 507
              |||.                                  |..:|||:
Mouse   390 --LNTD----------------------------------LTYQATSS----------------- 401

  Fly   508 TNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTA 572
                       .|.:.||....|  .||...|..:|.:.|.|                    ||
Mouse   402 -----------DSSAAPSVLGGR--MDPHRQGSNSTLHNSVS--------------------DT- 432

  Fly   573 SPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSV 637
                 :||
Mouse   433 -----VNS--------------------------------------------------------- 435

  Fly   638 TASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNV 702

Mouse   436 ----------------------------------------------------------------- 435

  Fly   703 QLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNV 767
                            .|...||.:||
Mouse   436 ----------------TKTEHTAVRGT-------------------------------------- 446

  Fly   768 LKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSV 832
                                                                        ::||.
Mouse   447 ------------------------------------------------------------SLRSK 451

  Fly   833 PTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAF 897
            |.|..                |:|::...|||
Mouse   452 PDSRA----------------VDSSAALHSPL--------------------------------- 467

  Fly   898 GQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFN 962
                                                    .|.||:|:|..|
Mouse   468 ----------------------------------------APNTSNNSSWVT------------- 479

  Fly   963 AGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQ 1027
                                                                  |:|:.:|
Mouse   480 ------------------------------------------------------DMLRKNE---- 486

  Fly  1028 HGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVS 1092
                                                      ||.|
Mouse   487 ------------------------------------------VDEI------------------- 490

  Fly  1093 GDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHT 1157
                                         |..|.|.                  :...|:   |.
Mouse   491 -----------------------------CALPATK------------------ISRVEV---HA 505

  Fly  1158 GCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELI 1222
            ..|            .|.:...|:|                    .|:|:|
Mouse   506 AAT------------PFSKETPSNP--------------------VAILKA-------------- 524

  Fly  1223 ERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSY--IDSNCI 1285
                                                  ::|..||:||:.:..|:.:  :.....
Mouse   525 --------------------------------------EQWCDVGIFKNNTALVSQFYLLPKGKQ 551

  Fly  1286 SDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAI 1350
            |.|.....||   ||:|...:.:|.|||.|:||::|||.||.|...::|.||||.||||||||.:
Mouse   552 SMSKVGNADV---PDYSLLKKQDLVPGTVYKFRVAAINGCGIGPLSKVSEFKTCTPGFPGAPSTV 613

  Fly  1351 KISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPN 1415
            :|||:| :|.||:|| ||...:..|:|||.|||:: ||:.:. :..||.|:|:|.|....|||..
Mouse   614 RISKNV-DGIHLSWE-PPTSPSGNILEYSAYLAIR-TAQMQD-NPSQLVFMRIYCGLKTSCTVTA 674

  Fly  1416 ASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQ 1453
            ..|:|||:|.:::|||:|||:|:|:|||||||||||||
Mouse   675 GQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQ 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	29/36 (81%)
		KELCH repeat	74..115	CDD:276965	32/40 (80%)
		KELCH repeat	123..175	CDD:276965	34/51 (67%)
		Kelch_3	132..184	CDD:290151	36/51 (71%)
		Kelch_5	175..221	CDD:290565	30/48 (63%)
		KELCH repeat	178..239	CDD:276965	33/63 (52%)
		Kelch_3	260..305	CDD:290151	24/44 (55%)
		KELCH repeat	297..360	CDD:276965	28/66 (42%)
		Kelch_3	306..371	CDD:290151	32/68 (47%)
		FN3	<1307..1338	CDD:238020	15/30 (50%)
		FN3	1344..1448	CDD:238020	53/103 (51%)
Hcfc2	XP_030101101.1	PLN02193	<2..262	CDD:177844	154/256 (60%)
		KELCH repeat	23..69	CDD:276965	34/45 (76%)
		KELCH repeat	127..186	CDD:276965	33/62 (53%)
		PLN02193	<232..>375	CDD:177844	76/142 (54%)
		KELCH repeat	245..312	CDD:276965	28/66 (42%)
		FN3	<547..601	CDD:238020	22/56 (39%)
		FN3	607..707	CDD:238020	53/103 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835712
Domainoid	1	1.000	269	1.000	Domainoid score	I1844
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	663	1.000	Inparanoid score	I751
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002961
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46003
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	1	1.000	-	-		X2316
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.020