DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcf and Lztr1

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_080084.2	Gene:	Lztr1 / 66863	MGIID:	1914113	Length:	837	Species:	Mus musculus

Alignment Length:	482	Identity:	105/482 - (21%)
Similarity:	166/482 - (34%)	Gaps:	138/482 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 TGFRWKRVLNP----TGPQPRPRHGHRAINIKELMVVFGGGN-EGIVDELHVYNTVTNQWYVPVL 115
            |..||:| |.|    .|.:   |..|..:..|:.:.||||.| :.::::|..::.....|.....
Mouse    47 TVHRWRR-LPPCDEFVGAR---RSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFT 107

  Fly   116 KGDVPNGCAAYGFVVEGTRMFVFGGMIE--YG----KYSNELYELQATKWEWRKMYPESPDSGLS 174
            .|..|.....:..||.|:.||||||...  |.    |..|:|:|.:....:|.:...|    |..
Mouse   108 TGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIE----GRL 168

  Fly   175 PCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHN-GKWIVPKTYGDS 238
            |..|..|..|:..:|:::|.|....:         .|||::   |.|:.... ..|......|:.
Mouse   169 PVARSAHGATVYSDKLWIFAGYDGNA---------RLNDMW---TIGLQDRELTCWEEVAQSGEI 221

  Fly   239 PPPRESHTGISFATKSNGNLNLLIYGGMSGCRL-GDLWLLETDSMTWSKPKTS----GEAPLPRS 298
            ||   |......|...:   .:.::.|.||.:: .:|:..|....||::..|.    |..|.|:.
Mouse   222 PP---SCCNFPVAVCRD---KMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQR 280

  Fly   299 LHSSTMIG--NKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENV----------- 350
            .:..||:.  ..:|||||       .:.:|...|..|      .|::..|||.|
Mouse   281 RYGHTMVAFDRHLYVFGG-------AADNTLPNELHC------YDVDFQTWEVVQPSSDSEVGGA 332

  Fly   351 -------------TLDTVEEN---------------------------VPRARAGHCAVGIQSRL 375
                         ||.:.|.:                           :|..|..|.|..|...:
Mouse   333 EMPERASSSEDASTLTSEERSSFKKSRDVFGLDFGTTSAKQPVHLASELPSGRLFHAAAVISDAM 397

  Fly   376 YVWSG------RDG------------------YRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRA 416
            |::.|      |.|                  |.:.|..:..|...:.|...:......||:|.|
Mouse   398 YIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTA 462

  Fly   417 STHALELSWTATTFAAAYVLQIQKIEQ 443
            .:.     |.......|.....||:|:
Mouse   463 RSR-----WLRRKIVQAQEWLAQKLEE 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	9/37 (24%)
		KELCH repeat	74..115	CDD:276965	10/41 (24%)
		KELCH repeat	123..175	CDD:276965	17/57 (30%)
		Kelch_3	132..184	CDD:290151	18/57 (32%)
		Kelch_5	175..221	CDD:290565	11/45 (24%)
		KELCH repeat	178..239	CDD:276965	13/61 (21%)
		Kelch_3	260..305	CDD:290151	12/49 (24%)
		KELCH repeat	297..360	CDD:276965	18/115 (16%)
		Kelch_3	306..371	CDD:290151	20/117 (17%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
Lztr1	NP_080084.2	KELCH repeat	65..111	CDD:276965	11/45 (24%)
		Kelch_3	74..123	CDD:290151	11/48 (23%)
		Kelch 1. /evidence=ECO:0000255	76..125		11/48 (23%)
		KELCH repeat	115..169	CDD:276965	17/57 (30%)
		Kelch_3	124..180	CDD:290151	19/59 (32%)
		Kelch 2. /evidence=ECO:0000255	127..182		18/58 (31%)
		Kelch_4	171..217	CDD:290154	12/57 (21%)
		Kelch 3. /evidence=ECO:0000255	184..235		13/65 (20%)
		Kelch_3	234..289	CDD:290151	13/57 (23%)
		Kelch 4. /evidence=ECO:0000255	236..282		11/45 (24%)
		Kelch_1	280..323	CDD:279660	15/55 (27%)
		KELCH repeat	281..323	CDD:276965	15/54 (28%)
		Kelch 5. /evidence=ECO:0000255	292..338		13/58 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..352		2/27 (7%)
		Kelch 6. /evidence=ECO:0000255	396..447		7/50 (14%)
		SPOP_C_like	571..631	CDD:269810
		BTB	662..761	CDD:279045
		BTB	665..762	CDD:197585
		SPOP_C_like	765..>804	CDD:269810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940