Protein Alignment Hcf and hcfc1a

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_001038529.2
• Gene: hcfc1a / 564853
• ZFINID: ZDB-GENE-030912-10
• Length: 1802
• Species: Danio rerio
• Alignment Length: 1859
• Identity: 617/1859 - (33%)
• Similarity: 854/1859 - (45%)
• Gaps: 519/1859 - (27%)

  Fly    59 RWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGC 123
            ||||||..:||.|||||||||:.||||||||||||||||||||||||.||||::|.::||:|.||
Zfish    17 RWKRVLGWSGPVPRPRHGHRAVAIKELMVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGC 81

  Fly   124 AAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGE 188
            ||||||.:|||:.|||||:|||||||:||||||::|||:|:.|::|.:|:.|||||||||::||.
Zfish    82 AAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKKLKPKAPKNGVPPCPRLGHSFSLVGN 146

  Fly   189 KIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATK 253
            |.:|||||||:|:|||||||:||||||.|:.|...|..| |.||.|||..||||||||.:.:..|
Zfish   147 KCYLFGGLANDSEDPKNNIPRYLNDLYTLELRPGSSVAG-WDVPVTYGVLPPPRESHTAVIYTEK 210

  Fly   254 SNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPL 318
            ......|:||||||||||||||.|:.|::||:||..||.|||||||||:|.|.||||||||||||
Zfish   211 VTKKSRLVIYGGMSGCRLGDLWTLDIDTLTWNKPAISGAAPLPRSLHSATTITNKMYVFGGWVPL 275

  Fly   319 VINDSK-STTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRD 382
            |::|.| :|.|:|||||||||.|:|:|:.||.|.:||:|:|:||||||||||.|.:|||:|||||
Zfish   276 VMDDVKVATHEKEWKCTNTLACLNLDTLAWETVLMDTLEDNIPRARAGHCAVAINNRLYIWSGRD 340

  Fly   383 GYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQP--- 444
            |||||||||||||||||||..:|....:|.||||:|::||:||.|.:.|..|:||:||.:.|
Zfish   341 GYRKAWNNQVCCKDLWYLETERPNPPSRVQLVRANTNSLEVSWGAVSTADTYLLQLQKYDIPAAT 405

  Fly   445 ------LNTSSKLLSN-----------------------NIVQQGTPTSAETSGINISANRSGSA 480
                  ||.:..|..|                       ::.|..:||::...|...|...:..|
Zfish   406 AATSPALNAAPSLPGNSPKSPAPAAAAPSAQSLPHSGITSVPQAASPTASVLPGTPASPLAASMA 470

  Fly   481 LGLGV-------EATSTVLKLEKESLQLSGCQPET--NVQPSVNDLLQSMSQPSSP--------- 527
            .|..:       ..|...:...:::.|: |..|.|  ::...|..::.|.:...:|
Zfish   471 RGPAILKVAAPQSGTGASIVTVRQASQV-GKSPVTVASLPAGVRMVVPSQTAQGTPIGSSPQMSG 534

  Fly   528 -------ASRADKDPLSSG--------------------GGTTFNLSTSVAS----VHPQISVIS 561
                   |:...|.|.|.|                    |.:|...:..|||    .:|...::.
Zfish   535 MAALAAAAAATQKIPPSPGATVLNMPAGATIVKTVAVTPGASTLPTTVKVASPLMVSNPATRMLK 599

  Fly   562 STAAVTGNDTAS--PSGAINSILQKFRPVVTAVRTST----------TTAVSIATST----SDPL 610
            :.||.....|.|  .:||        ||::|..::.|          ||.|...|.|    ..||
Zfish   600 TAAAQVATPTVSSPTTGA--------RPIITVHKSGTVTVAQQAQVVTTVVGGVTKTITLVKSPL 656

  Fly   611 SV---------RVPSTM------SANVVLSSSS---------------STLRIVPSVTASHSLRI 645
            |:         :|.|.:      ||.|...:|:               :.|::|.|.....:..|
Zfish   657 SMGGNLISNLGKVVSVVQNKPVQSATVTGQASNPLTQIIQTKGPLPPGTILKLVTSADGKPTTII 721

  Fly   646 ASSQASGNNCRSS---------------SAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKP 695
            .:|||.|...:.:               ....|:|| :|..||| |..:..|::.|     ::.|
Zfish   722 TTSQAGGTGNKPTILGISGMSPTSTSKPGTTTIIKT-IPMSAVQ-QGAAGVTSTTG-----VKSP 779

  Fly   696 LTLAPNVQLQFVKTSG--GMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPG--S 756
            :|:....    |.|||  |..:..:||:...|.:               .|:||:.....||  .
Zfish   780 ITIITTK----VMTSGTPGKIITAMPKIGTAAGQ---------------QGLTQVVLKGAPGQPG 825

  Fly   757 QIQKPIVSGNVLKLVSP------------------------------HTMAGGKLIMKNSN---- 787
            .|.:.:..|.| :||||                              .::|||.|...|:.
Zfish   826 TILRTVPMGGV-RLVSPVSGVKPTVTTLVVKGTTGVTTLGTVTGTVSSSLAGGSLASANATLATP 889

  Fly   788 ILQMGKV---------TPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRS------------ 831
            |..:|.:         ..||...:...........|   .|:.::||...|.:
Zfish   890 ITTLGTIATLASQVINATNVTAAQSNLTTVTSTMQP---TQVTLITTPSGVEAQPGQDLPVSFLA 951

  Fly   832 -----VPTSTVMTSAGGSASGTNIVSIV--------NSTSTTPSPLQALSGQ--------KTLIS 875
                 .||||  .|..|.|||:  |::|        :.|.||.:...|.|..        :.:.|
Zfish   952 SPTSEQPTST--ESGTGEASGS--VTLVCSNPPCETHETGTTNTATTATSNMGAGPAGTVQRVCS 1012

  Fly   876 N------QSGVKMLRNISSVQASSSMAFGQK----------QSGTPIHQKTALYIGGKAV--TVM 922
            |      ::|.    ..::..||::|...|:          ::||.....||....|.|.  ||.
Zfish  1013 NPPCETHETGT----TNTATTASANMGAVQRVCSNPPCETHETGTTSTTTTASSNMGTAPAGTVQ 1073

  Fly   923 --------------STNTSMAASGN----------KVMVLPGTSSNNSPATTTALSARKSFVFNA 963
                          :|||:..||.|          :|...|...::.:..|.||.:|..|.   .
Zfish  1074 RVCSNPPCETHETGTTNTATTASSNMGGNQPGAVQRVCSNPPCETHETGTTNTATTASSSM---G 1135

  Fly   964 GGSPRTV------------------TLATKSIN-----AKSIPQ--SQPVTETNNHSVATIKDTD 1003
            ||...||                  |..|.|.|     |.::.:  |.|..||:.........|.
Zfish  1136 GGQEGTVQRVCSNPPCETHETGTTNTATTSSSNMGGDQAGAVQRVCSNPPCETHETGTTNTATTA 1200

  Fly  1004 PMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSS--SASALFTGGDTA--------GPS 1058
            ..:            ::..|...|..||.:|::...:|.|  :.:|...|..|.        ||:
Zfish  1201 TCN------------METDEGTAQQTSEASESSTSTSTESLPATAAAQRGAITTVTQATPLPGPA 1253

  Fly  1059 -------------RAQNPIVMEH--------------------------------PVDIIEDVSG 1078
                         ....|:|||.                                |.|..||.:.
Zfish  1254 VPSISSITESSSEAGAEPVVMESSEAESLQTEGQAEAEAVAMQAEFQTEAGAVALPTDFQEDAAA 1318

  Fly  1079 VSSTTDVNETAI----------------VSG-----DTIESLKMSEKENDDVKSMGEKSILS--- 1119
            :.:.......|:                |||     ...|.|..:|.|:.|..|..:.::|:
Zfish  1319 LPADFQGEAVAVAMQAESQADAVPMEQDVSGMAEGEAAQEQLPTAEMEDVDAASASQAAVLALPP 1383

  Fly  1120 ---DDCHQPT-------------------------TSETEAATILTTIKSAEALVLETA--EIRK 1154
               .|....|                         |.|.:|..|...:::|:..|:..|  :.::
Zfish  1384 ELMADGQSTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMSDAGGDDQQ 1448

  Fly  1155 DH------TGCTIGSLKENQDENKKFKQR---QESSPSQNIHQFQNVDGSQLEALASAALLQAAT 1210
            .|      |...:.:|.:.|.:.:..:|:   |.:.|::.:....:::....|:.....:..|||
Zfish  1449 THTIPIVLTQQELAALVQQQQQLQAAQQQAAAQAALPTEGLAPADSLNDPLSESNGHNEMAAAAT 1513

  Fly  1211 SDTTALALKELIERPESETNTRSSNIAEI----------------QQNNV----QSTLAVVVPNT 1255
            |     |:..|:.|..:||...||.:|.:                ..|.:    |:...|.|...
Zfish  1514 S-----AVVTLLPRTAAETLAPSSTLAPVVVASPAKMQAAAALTEVANGIEAGKQNPPTVTVKPQ 1573

  Fly  1256 SQNENQKWHTVGVFKDLSHTVTS-YIDSNCISDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRL 1319
            .:.||| |..||:.|..:..||. |:.::   ||.:...|....||:|:..|..|:|||||:||:
Zfish  1574 VKKENQ-WFDVGIVKVTNTVVTHFYMPAD---DSAYVENDSGTAPDYSQMKRVELQPGTAYKFRV 1634

  Fly  1320 SAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAV 1384
            :.||:||||.:.|||:||||||||||||.||||||. .:|||||||||.....| |.|||||||:
Zfish  1635 AGINTCGRGTFSEISAFKTCLPGFPGAPCAIKISKS-PDGAHLTWEPPSVTSGK-ITEYSVYLAI 1697

  Fly  1385 K--PTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPAT 1447
            :  .|.:.|..:..||||:|||.|....|.|.::||||||:|.:.||||||||||||:|||||||
Zfish  1698 QSSQTTEAKPSAPAQLAFMRVYCGPNPSCLVQSSSLSNAHIDYTTKPAIIFRIAARNEKGYGPAT 1762

  Fly  1448 QVRWLQ----DPAAAKQHTPTVTPNLKR---GPEKSTIG 1479
            ||||||    |..:||       |..||   .|:...||
Zfish  1763 QVRWLQESSKDGLSAK-------PAPKRAVSSPDTKGIG 1794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	209/304 (69%)
		KELCH repeat	74..115	CDD:276965	35/40 (88%)
		KELCH repeat	123..175	CDD:276965	35/51 (69%)
		KELCH repeat	178..239	CDD:276965	40/60 (67%)
		KELCH repeat	297..360	CDD:276965	43/63 (68%)
		FN3	<1307..>1381	CDD:442628	49/73 (67%)
		FN3	<1307..1338	CDD:238020	18/30 (60%)
		FN3	1344..1448	CDD:238020	65/105 (62%)
hcfc1a	NP_001038529.2	None