DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and hcfc2

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_001314768.1 Gene:hcfc2 / 550401 ZFINID:ZDB-GENE-050417-203 Length:708 Species:Danio rerio


Alignment Length:1453 Identity:349/1453 - (24%)
Similarity:473/1453 - (32%) Gaps:777/1453 - (53%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCA 124
            ||||.:..||.||.||||||:.|:||:||||||||||..:|||||:||.||::|.::||:|.|||
Zfish     8 WKRVRSYAGPVPRARHGHRAVAIRELLVVFGGGNEGIATDLHVYNSVTKQWFLPAVRGDIPPGCA 72

  Fly   125 AYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEK 189
            |:|||.||||:.|||||:|:|:|:|.||||||::|.|:|:.|..|.:|..||||:|||||:...|
Zfish    73 AHGFVCEGTRILVFGGMVEFGQYTNSLYELQASRWLWKKLKPRPPKNGSLPCPRIGHSFTLHANK 137

  Fly   190 IFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKS 254
            .:||||:||:|:||..|||:||:|.|.|:.:......| |.||:|.|..|..||||:.:.:..|.
Zfish   138 CYLFGGMANDSEDPNGNIPRYLDDFYELELQAQSGVKG-WNVPETKGGGPSARESHSSVVYCGKG 201

  Fly   255 NGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLV 319
            ..:..|.|:|||.|.||.|||.|:.::||||.|.|.|:.|||||||:|.:||||:||||||||:.
Zfish   202 GSSPRLYIFGGMCGDRLNDLWQLDIETMTWSLPPTRGQLPLPRSLHTSNVIGNKLYVFGGWVPIG 266

  Fly   320 INDSKSTTER-EWKCTNTLAVLDLETMTWENVT--------LDTVEENV--PRARAGHCAVGIQS 373
            ..:.....:. :|.|||:|::|:.:|:||.|:|        ::..|.|.  ||||||||||.:.|
Zfish   267 EEEEALAADGVKWICTNSLSMLNFDTLTWHNLTPEEHQQGLVEQDENNADWPRARAGHCAVTVGS 331

  Fly   374 RLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQI 438
            ||.:|||||||:|..|.|||||||||||..:|.....|.||:::...|.::|.....|..|:||:
Zfish   332 RLCIWSGRDGYKKYNNYQVCCKDLWYLETERPATPGAVFLVKSTISMLHVAWRPLLAAECYLLQL 396

  Fly   439 QKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSG 503
            |.|                                                              
Zfish   397 QPI-------------------------------------------------------------- 399

  Fly   504 CQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTG 568
                                                                             
Zfish   400 ----------------------------------------------------------------- 399

  Fly   569 NDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRI 633
                                                                             
Zfish   400 ----------------------------------------------------------------- 399

  Fly   634 VPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTL 698
                |:.||                              ..::|                     
Zfish   400 ----TSHHS------------------------------TSAEP--------------------- 409

  Fly   699 APNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIV 763
                             ||.|         |||                                
Zfish   410 -----------------QTAP---------TPP-------------------------------- 416

  Fly   764 SGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGN 828
                                                                             
Zfish   417 ----------------------------------------------------------------- 416

  Fly   829 VRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASS 893
                                            |.|                              
Zfish   417 --------------------------------PEP------------------------------ 419

  Fly   894 SMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKS 958
                                                                             
Zfish   420 ----------------------------------------------------------------- 419

  Fly   959 FVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSE 1023
                                                                             
Zfish   420 ----------------------------------------------------------------- 419

  Fly  1024 SEGQHGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNET 1088
                                                                             
Zfish   420 ----------------------------------------------------------------- 419

  Fly  1089 AIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIR 1153
                ||..||::...| :.|||...||...|                                  
Zfish   420 ----GDRRESVQKDAK-SADVKIKREKDYSS---------------------------------- 445

  Fly  1154 KDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALAL 1218
                                    |||..||   :.:..||:.::...                 
Zfish   446 ------------------------QESPLSQ---KEKGKDGADIQPTE----------------- 466

  Fly  1219 KELIERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSYI--- 1280
            :::...|..:                        |.|:::    |..|||||.|...||.|.   
Zfish   467 RDISPEPSKQ------------------------PETTKD----WFDVGVFKTLFCEVTHYFLPS 503

  Fly  1281 ---DSNCISDSFFDGIDVD-NLP---DFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKT 1338
               |...:..:.:...|.: .||   .|:...:..|:.|..||||::.:||||.|::..||.|||
Zfish   504 ENGDMASVLSAQYTSSDTEWKLPGPHSFTGCEKQELDSGITYRFRVAGLNSCGLGDFSPISEFKT 568

  Fly  1339 CLPGFPGAPSAIKISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTP-QLAFVR 1402
            |.|||||||||:||:|.. :..|::||||.:...| |:|||:||||:.:..:..:..| :|||:|
Zfish   569 CQPGFPGAPSAVKITKGT-DSVHISWEPPTSVSGK-IMEYSMYLAVRKSRGNSLVERPGELAFIR 631

  Fly  1403 VYVGAANQCTVPNASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTP 1467
            :|.|....|||..|.|||||:|||.:|||:|||||:|.:|||||||:|||||.:..|   |:|.|
Zfish   632 IYRGTKTSCTVTEAQLSNAHIDCSARPAIVFRIAAKNDQGYGPATQIRWLQDASKLK---PSVMP 693

  Fly  1468 NLKRGPEKSTIGSSNIA--NTFC 1488
                     |..||:.|  :|.|
Zfish   694 ---------TDSSSSAAEPDTTC 707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 26/36 (72%)
KELCH repeat 74..115 CDD:276965 29/40 (73%)
KELCH repeat 123..175 CDD:276965 31/51 (61%)
Kelch_3 132..184 CDD:290151 31/51 (61%)
Kelch_5 175..221 CDD:290565 27/45 (60%)
KELCH repeat 178..239 CDD:276965 30/60 (50%)
Kelch_3 260..305 CDD:290151 27/44 (61%)
KELCH repeat 297..360 CDD:276965 30/73 (41%)
Kelch_3 306..371 CDD:290151 34/75 (45%)
FN3 <1307..1338 CDD:238020 14/30 (47%)
FN3 1344..1448 CDD:238020 56/104 (54%)
hcfc2NP_001314768.1 Kelch_1 21..58 CDD:279660 26/36 (72%)
KELCH repeat 22..60 CDD:276965 28/37 (76%)
KELCH repeat 72..122 CDD:276965 30/49 (61%)
Kelch_3 80..134 CDD:290151 33/53 (62%)
Kelch_5 123..167 CDD:290565 27/43 (63%)
KELCH repeat 126..186 CDD:276965 30/60 (50%)
KELCH repeat 189..240 CDD:276965 24/50 (48%)
Kelch_3 206..252 CDD:290151 27/45 (60%)
KELCH repeat 244..318 CDD:276965 30/73 (41%)
Kelch_3 253..327 CDD:290151 32/73 (44%)
FN3 574..677 CDD:238020 56/104 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170579042
Domainoid 1 1.000 272 1.000 Domainoid score I1766
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 645 1.000 Inparanoid score I788
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D202078at33208
OrthoFinder 1 1.000 - - FOG0002961
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR46003
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
77.000

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