Protein Alignment Hcf and FBXO42

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_061867.1
• Gene: FBXO42 / 54455
• HGNCID: 29249
• Length: 717
• Species: Homo sapiens
• Alignment Length: 937
• Identity: 188/937 - (20%)
• Similarity: 311/937 - (33%)
• Gaps: 345/937 - (36%)

  Fly    18 SASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINI 82
            |:||...:..:..:........:||.|......|::..|                 ||......:
Human     3 SSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEET-----------------RHNRSMSEL 50

  Fly    83 KELMVVFGGGNEGIVDELHVYN------TVTNQWYVPVLKGDVPNGCAAYGF---VVEGT----- 133
            .|.::      |.|:..|..|.      .|..||| .::|| |.:.| .:||   |.||.
Human    51 PEEVL------EYILSFLSPYQEHKTAALVCKQWY-RLIKG-VAHQC-YHGFMKAVQEGNIQWES 106

  Fly   134 -------------------------RMFVFGGMIEYGKYS--NELYELQATKWEWRKMYPESPDS 171
                                     .|:||||..:....:  |:|:.|.....||.:...    |
Human   107 RTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLA----S 167

  Fly   172 GLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKW--IVPKT 234
            |..|.|:.|.:..:..:.:.||||....|..|.:...::.::::      .:|.:..|  .:..|
Human   168 GSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIH------TYSPSKNWWNCIVTT 226

  Fly   235 YGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCR--LGDLWLLETDSMTWSKPKTSGEAPLPR 297
            :|  |||...|:......|      ::::||..|.|  ..|:|:|:.:...||||..||.:|.||
Human   227 HG--PPPMAGHSSCVIDDK------MIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPR 283

  Fly   298 SLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRA 362
                           ||...:||:|:            |:.:|
Human   284 ---------------GGQSQIVIDDA------------TILIL---------------------- 299

  Fly   363 RAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTA 427
              |.|  |..:.|:                  ||.|.|.:....:|.:...|....|.....|
Human   300 --GGC--GGPNALF------------------KDAWLLHMHSGPWAWQPLKVENEEHGAPELW-- 340

  Fly   428 TTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVL 492
             ...|..|.|...:.....:....||.::..:.:|.||                        |..
Human   341 -CHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISA------------------------TPP 380

  Fly   493 KLEKESLQLSGCQPETNVQ--PSVN---DLLQSMSQPSSPA---------SRADKDPLSSGGGTT 543
            .|..|:.:.....|..::.  |.||   ..|:..:|..:|:         :|.|..|:.:||
Human   381 ALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGG--- 442

  Fly   544 FNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTA--------- 599
                          |:...||||.|:...||              |.|:..||.:|
Human   443 --------------SLSPGTAAVGGSSLDSP--------------VQAISPSTPSAPEGYDLKIG 479

  Fly   600 VSIAT---STSDPLSVRVPS-TMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSA 660
            :|:|.   |..|...:|:.| .::.::..:|||:.:..:.:.|...|:|....|.:|.:
Human   480 LSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVH------ 538

  Fly   661 INILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTA 725
                  ..|:||          :::.|                    ..|.|...::|..:...:
Human   539 ------TPPHVA----------SALAG--------------------AVSPGALRRSLEAIKAMS 567

  Fly   726 SKG-------TPPHGISIANP---HLASGITQIQGSTVPGSQIQKPIVS---GNVLKLVS----- 772
            |||       :||.|.|..:|   .|:|      |.|||   |.:|..:   |:.|..::
Human   568 SKGPSASAALSPPLGSSPGSPGSQSLSS------GETVP---IPRPGPAQGDGHSLPPIARRLGH 623

  Fly   773 --PHTMAGGKLIMKNSNI--LQM-----------GKVTPNVMG-----GKPAFVITNKQGTPLGN 817
              |.::..||.:.::.|.  :||           |:|...|..     |.|.   |:......|.
Human   624 HPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPE---TSLHTVVQGR 685

  Fly   818 QQIIIVTTGG------NVRSVPTSTVM 838
            .::||.  ||      ||:..|.:..:
Human   686 GELIIF--GGLMDKKQNVKYYPKTNAL 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	73/348 (21%)
		KELCH repeat	74..115	CDD:276965	11/46 (24%)
		KELCH repeat	123..175	CDD:276965	18/86 (21%)
		KELCH repeat	178..239	CDD:276965	11/62 (18%)
		KELCH repeat	297..360	CDD:276965	8/62 (13%)
		FN3	<1307..>1381	CDD:442628
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
FBXO42	NP_061867.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..34		6/30 (20%)
		F-box_FBXO42	47..84	CDD:438882	9/43 (21%)
		NanM	110..>313	CDD:442289	59/291 (20%)
		KELCH repeat	119..168	CDD:276965	10/52 (19%)
		Kelch 1	132..184		15/55 (27%)
		KELCH repeat	174..229	CDD:276965	11/62 (18%)
		Kelch 2	186..242		14/63 (22%)
		KELCH repeat	232..271	CDD:276965	9/44 (20%)
		Kelch 3	244..293		20/63 (32%)
		Kelch 4	295..342		14/93 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..474		33/167 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..631		17/69 (25%)