DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and FBXO42

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_061867.1 Gene:FBXO42 / 54455 HGNCID:29249 Length:717 Species:Homo sapiens


Alignment Length:937 Identity:188/937 - (20%)
Similarity:311/937 - (33%) Gaps:345/937 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 SASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINI 82
            |:||...:..:..:........:||.|......|::..|                 ||......:
Human     3 SSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEET-----------------RHNRSMSEL 50

  Fly    83 KELMVVFGGGNEGIVDELHVYN------TVTNQWYVPVLKGDVPNGCAAYGF---VVEGT----- 133
            .|.::      |.|:..|..|.      .|..||| .::|| |.:.| .:||   |.||.     
Human    51 PEEVL------EYILSFLSPYQEHKTAALVCKQWY-RLIKG-VAHQC-YHGFMKAVQEGNIQWES 106

  Fly   134 -------------------------RMFVFGGMIEYGKYS--NELYELQATKWEWRKMYPESPDS 171
                                     .|:||||..:....:  |:|:.|.....||.:...    |
Human   107 RTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLA----S 167

  Fly   172 GLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKW--IVPKT 234
            |..|.|:.|.:..:..:.:.||||....|..|.:...::.::::      .:|.:..|  .:..|
Human   168 GSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIH------TYSPSKNWWNCIVTT 226

  Fly   235 YGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCR--LGDLWLLETDSMTWSKPKTSGEAPLPR 297
            :|  |||...|:......|      ::::||..|.|  ..|:|:|:.:...||||..||.:|.||
Human   227 HG--PPPMAGHSSCVIDDK------MIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPR 283

  Fly   298 SLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRA 362
                           ||...:||:|:            |:.:|                      
Human   284 ---------------GGQSQIVIDDA------------TILIL---------------------- 299

  Fly   363 RAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTA 427
              |.|  |..:.|:                  ||.|.|.:....:|.:...|....|.....|  
Human   300 --GGC--GGPNALF------------------KDAWLLHMHSGPWAWQPLKVENEEHGAPELW-- 340

  Fly   428 TTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVL 492
             ...|..|.|...:.....:....||.::..:.:|.||                        |..
Human   341 -CHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISA------------------------TPP 380

  Fly   493 KLEKESLQLSGCQPETNVQ--PSVN---DLLQSMSQPSSPA---------SRADKDPLSSGGGTT 543
            .|..|:.:.....|..::.  |.||   ..|:..:|..:|:         :|.|..|:.:||   
Human   381 ALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGG--- 442

  Fly   544 FNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTA--------- 599
                          |:...||||.|:...||              |.|:..||.:|         
Human   443 --------------SLSPGTAAVGGSSLDSP--------------VQAISPSTPSAPEGYDLKIG 479

  Fly   600 VSIAT---STSDPLSVRVPS-TMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSA 660
            :|:|.   |..|...:|:.| .::.::..:|||:.:..:.:.|...|:|....|.:|.:      
Human   480 LSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVH------ 538

  Fly   661 INILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTA 725
                  ..|:||          :::.|                    ..|.|...::|..:...:
Human   539 ------TPPHVA----------SALAG--------------------AVSPGALRRSLEAIKAMS 567

  Fly   726 SKG-------TPPHGISIANP---HLASGITQIQGSTVPGSQIQKPIVS---GNVLKLVS----- 772
            |||       :||.|.|..:|   .|:|      |.|||   |.:|..:   |:.|..::     
Human   568 SKGPSASAALSPPLGSSPGSPGSQSLSS------GETVP---IPRPGPAQGDGHSLPPIARRLGH 623

  Fly   773 --PHTMAGGKLIMKNSNI--LQM-----------GKVTPNVMG-----GKPAFVITNKQGTPLGN 817
              |.::..||.:.::.|.  :||           |:|...|..     |.|.   |:......|.
Human   624 HPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPE---TSLHTVVQGR 685

  Fly   818 QQIIIVTTGG------NVRSVPTSTVM 838
            .::||.  ||      ||:..|.:..:
Human   686 GELIIF--GGLMDKKQNVKYYPKTNAL 710

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 8/42 (19%)
KELCH repeat 74..115 CDD:276965 11/46 (24%)
KELCH repeat 123..175 CDD:276965 18/86 (21%)
Kelch_3 132..184 CDD:290151 16/83 (19%)
Kelch_5 175..221 CDD:290565 9/45 (20%)
KELCH repeat 178..239 CDD:276965 11/62 (18%)
Kelch_3 260..305 CDD:290151 16/46 (35%)
KELCH repeat 297..360 CDD:276965 8/62 (13%)
Kelch_3 306..371 CDD:290151 9/64 (14%)
FN3 <1307..1338 CDD:238020
FN3 1344..1448 CDD:238020
FBXO42NP_061867.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34 6/30 (20%)
F-box-like 47..>82 CDD:315592 9/41 (22%)
KELCH repeat 119..168 CDD:276965 10/52 (19%)
Kelch_3 130..182 CDD:315978 15/55 (27%)
Kelch 1 132..184 15/55 (27%)
KELCH repeat 174..229 CDD:276965 11/62 (18%)
Kelch_3 183..240 CDD:315978 14/64 (22%)
Kelch 2 186..242 14/63 (22%)
Guanylate_kin 228..>360 CDD:331880 44/213 (21%)
Kelch_5 229..268 CDD:316377 12/44 (27%)
KELCH repeat 232..271 CDD:276965 9/44 (20%)
Kelch 3 244..293 20/63 (32%)
Kelch 4 295..342 14/93 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 361..474 33/167 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 570..631 17/69 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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