Protein Alignment Hcf and klhdc3

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: NP_001430365.1
• Gene: klhdc3 / 406553
• ZFINID: ZDB-GENE-040426-2426
• Length: 382
• Species: Danio rerio
• Alignment Length: 322
• Identity: 89/322 - (27%)
• Similarity: 142/322 - (44%)
• Gaps: 52/322 - (16%)

  Fly    11 FSSGERISASDLNSEHIIQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNP--TGPQ--- 70
            :|.|...|..|.  |.:.|.:.|.|                  |....||.: |.|  ||.:
Zfish    27 YSFGGYCSGEDY--ETLRQIDVHVF------------------NTVSLRWTK-LPPVRTGGREHA 70

  Fly    71 ---PRPRHGHRAINIKELMVVFGGGN--EGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVV 130
               |..|:||.|:...:.::::||.|  ||..:.|:.::...::|:.|.:.|.||.....:...|
Zfish    71 REVPYMRYGHTAVLADDTILIWGGRNDTEGACNVLYAFDINQHRWFTPKISGTVPGARDGHSACV 135

  Fly   131 EGTRMFVFGGMIEYGK-YSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFG 194
            .|..|::|||..:... :|||:::|..:...|..:...    |.....|..||.|::|.|:|:||
Zfish   136 LGKAMYIFGGYEQLADCFSNEIHKLDTSNMCWSLVNAR----GTPARWRDFHSATIIGTKMFVFG 196

  Fly   195 GLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLN 259
            |.|:......:|...|.|.:.|.||     ....|:...|....|..|.||:..::    ||  .
Zfish   197 GRADRFGPFHSNNEIYCNKIKIFDT-----ETNSWMNTHTAQLMPEGRRSHSAFAY----NG--E 250

  Fly   260 LLIYGGMSGCRL----GDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVP 317
            |.|:||.: .||    .|||....::.:|.|.:..|:.|.||......|:|:::.:|||..|
Zfish   251 LYIFGGYN-ARLDRHFNDLWKFSPEAFSWKKVEPRGKGPCPRRRQCCCMVGDRIILFGGTSP 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	80/274 (29%)
		KELCH repeat	74..115	CDD:276965	12/42 (29%)
		KELCH repeat	123..175	CDD:276965	12/52 (23%)
		KELCH repeat	178..239	CDD:276965	19/60 (32%)
		KELCH repeat	297..360	CDD:276965	7/21 (33%)
		FN3	<1307..>1381	CDD:442628
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
klhdc3	NP_001430365.1	None