DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcf and slim

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_523782.1	Gene:	slim / 37121	FlyBaseID:	FBgn0261477	Length:	609	Species:	Drosophila melanogaster

Alignment Length:	456	Identity:	101/456 - (22%)
Similarity:	160/456 - (35%)	Gaps:	127/456 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SDFVDPAFSSGERISASDLNSEHIIQAENHSFANRISM--------------DMDVP-------D 47
            ||.:|    .|..:|.|.||.......:....|.:|.|              |..:|       .
  Fly   144 SDELD----EGTELSKSVLNVFLSSDKQQSQMAGQIPMYAFQPLRLVKCQYRDKHIPGGFPLARS 204

  Fly    48 GHQLDS------NLTGFRWKRVLNPTGPQPRPRHGHRAINIKEL----------MVVFGGGN--- 93
            ||::.:      :|.|:      ||.......||| |.:..:||          .:....||
  Fly   205 GHRIIASNSHLYSLGGY------NPRSAMSASRHG-RCLLFQELWSYNFATRTWRLELNAGNAAN 262

  Fly    94 ---EGIVDELHVYNTV---------------TNQWYV---------P-----VLKGDVPNGCAAY 126
               |...:.|.::|.|               :|..||         |     .:|||:|......
  Fly   263 MPVELASNALTIHNNVLISHGGTGYPFGVSCSNDCYVYRTASAGATPGVDRLQVKGDLPTAQYGP 327

  Fly   127 GFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIF 191
            |.|:....::..||...: .|:.::|.|......|..:|...|:....|..|..|.....|:.||
  Fly   328 GIVIHKHFLYTIGGTTGF-DYTCDVYRLDLRTGIWENVYISRPEMRDDPEGRYRHEVVYDGKHIF 391

  Fly   192 LFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDS------------PPPRES 244
            :.||..:.|......||.|            :.....|...:||.|.            |.||:.
  Fly   392 VLGGGTSHSVYDLQRIPAY------------NLEANCWDYFETYPDQRAADADDGNRGYPKPRKC 444

  Fly   245 HTGISFATKSNGNLNLLIYGGMSG---CRLGDLWLLETDSMTWSKPKTSGEAPLPRSL--HSSTM 304
            .:.:...: |.|::...|.||:.|   ....|:|.|...:..|.:.:|   |.|||.|  ||:..
  Fly   445 FSCVQHQS-STGDIEAFITGGLQGDFSTYFSDIWKLNLRTKHWYRIET---AILPRPLYFHSAAH 505

  Fly   305 IGNK-MYVFGGWVPLVINDSKSTTE--REWKCTNTLAVLDLETMTWENVTLD------TVEENVP 360
            ..|. |||||| :..:..:.:...:  :.|.....|:.:..:.:|:.|..||      .:|..:|
  Fly   506 SDNGCMYVFGG-IEYIDKEMRRRNDLYKMWMTVPKLSEMCWDAITYYNDNLDLYDRKTLLEAGIP 569

  Fly   361 R 361
            :
  Fly   570 K 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	13/67 (19%)
		KELCH repeat	74..115	CDD:276965	16/85 (19%)
		KELCH repeat	123..175	CDD:276965	10/51 (20%)
		Kelch_3	132..184	CDD:290151	11/51 (22%)
		Kelch_5	175..221	CDD:290565	12/45 (27%)
		KELCH repeat	178..239	CDD:276965	15/72 (21%)
		Kelch_3	260..305	CDD:290151	16/49 (33%)
		KELCH repeat	297..360	CDD:276965	18/73 (25%)
		Kelch_3	306..371	CDD:290151	15/65 (23%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
slim	NP_523782.1	KELCH repeat	203..263	CDD:276965	14/66 (21%)
		KELCH repeat	267..321	CDD:276965	10/53 (19%)
		KELCH repeat	324..364	CDD:276965	8/40 (20%)
		Kelch_1	325..372	CDD:279660	10/47 (21%)
		Kelch_4	441..492	CDD:290154	13/54 (24%)
		KELCH repeat	442..495	CDD:276965	13/56 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446740
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840