DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hcf and Hcfc1

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:XP_006229655.1 Gene:Hcfc1 / 363519 RGDID:1563804 Length:2091 Species:Rattus norvegicus


Alignment Length:2143 Identity:641/2143 - (29%)
Similarity:881/2143 - (41%) Gaps:799/2143 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    59 RWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGC 123
            |||||:..:||.|||||||||:.||||:|||||||||||||||||||.||||::|.::||:|.||
  Rat    18 RWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGC 82

  Fly   124 AAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGE 188
            ||||||.:|||:.|||||:|||||||:||||||::|||:::..::|.:|..|||||||||::||.
  Rat    83 AAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGN 147

  Fly   189 KIFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISF 250
            |.:|||||||:|:|||||||:||||||||:.|   ||.:    |.:|.|||..||||||||.:.:
  Rat   148 KCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVA----WDIPITYGVLPPPRESHTAVVY 208

  Fly   251 ATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGW 315
            ..|.|....|:||||||||||||||.|:.:::||:||..||.|||||||||:|.|||||||||||
  Rat   209 TEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGW 273

  Fly   316 VPLVINDSK-STTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWS 379
            ||||::|.| :|.|:|||||||||.|:|:||.||.:.:||:|:|:||||||||||.|.:|||:||
  Rat   274 VPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWS 338

  Fly   380 GRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQP 444
            ||||||||||||||||||||||..||....:|.||||:|::||:||.|...|.:|:||:||.:.|
  Rat   339 GRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIP 403

  Fly   445 LN--TSSKLLSN------------------------------NIVQQGTPTSAETSGINISANRS 477
            ..  |::....|                              .:|.|.......|:.|.:.....
  Rat   404 ATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVP 468

  Fly   478 GSALGLGVEATS----TVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSS 538
            ||::.:...|.:    .|||:             |..|.:....|.:|    .|||:|.|.|:  
  Rat   469 GSSISVPTAARTQGVPAVLKV-------------TGPQATTGTPLVTM----RPASQAGKAPV-- 514

  Fly   539 GGGTTFNLSTSVASVHP----QISVISSTAAVTGNDT-ASPSGAINSILQKFRPVVTAVRTSTTT 598
               |..:|..||..|.|    |.:||.|...::|... |:.:.|...|.....|.|.:|...||.
  Rat   515 ---TVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTI 576

  Fly   599 AVSIAT---STSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSA 660
            ..::|.   :|:.|.:|:|.|    :.|:.|:.:| |::.:..|    ::.:|.:|..|..:...
  Rat   577 VKTVAVTPGTTTLPATVKVAS----SPVMVSNPAT-RMLKTAAA----QVGTSVSSAANTSTRPI 632

  Fly   661 INILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTA 725
            |.:.|:....||.|:|   ..||.:||    :.|.:||   |:.......|...:..|.||    
  Rat   633 ITVHKSGTVTVAQQAQ---VVTTVVGG----VTKTITL---VKSPISVPGGSALISNLGKV---- 683

  Fly   726 SKGTPPHGISI--ANPHLASGITQIQGSTVPGSQI---QKPIVSGNVLKL--------------- 770
                    :|:  ..|...|.:|. |.||.|.:||   :.|:.:|.:|||               
  Rat   684 --------MSVVQTKPVQTSAVTG-QASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTT 739

  Fly   771 ----------------VSPHTMAGG-----KLIMKNSNILQMGK---------------VTPNVM 799
                            |||.|...|     |.|..::.|.|.|.               :|..||
  Rat   740 QASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSSPGIKSPITIITTKVM 804

  Fly   800 ---GGKPAFVIT---------NKQG-------------------TPLGNQQII------------ 821
               .|.||.:||         .:||                   .|:|..:::            
  Rat   805 TSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVPMGGVRLVTPVTVSAVKPAV 869

  Fly   822 ---IV--TTGGNVRSVPTSTVMTSAGGSASGTNIVS-----------------IVNSTSTTPSPL 864
               :|  |||.......|.||.||..|:.:.:...|                 ::|.|:.|.|..
  Rat   870 TTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAA 934

  Fly   865 Q----ALSG---------------QKTLISNQSGVK----------MLRNISSVQASSSMAF--- 897
            |    |..|               |.|||:..|||:          :|.:.::.|.::::..   
  Rat   935 QTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADS 999

  Fly   898 --GQKQSGTPI-----------------------------------------HQKTALYI----- 914
              |..|.||..                                         .|:.|..:     
  Rat  1000 GQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAV 1064

  Fly   915 ---GGKAVTVMS-----------TNTSMAASGN-------------------------------- 933
               .|..|.|.|           |||:..|:.|                                
  Rat  1065 GQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGT 1129

  Fly   934 ----------------KVMVLPG--------------TSSNNSPATTTALSA-----------RK 957
                            ::.|.||              |...|..:||..:.|           |.
  Rat  1130 GQQRDARRATNTPTVVRITVAPGALERAQGTVKPPCQTQQTNMTSTTMTVQATGAPCSAGPLLRP 1194

  Fly   958 SFVFNAGG-SPRTVTLATKSI------------------------------------------NA 979
            |.....|. ||..|.||..|:                                          .|
  Rat  1195 SVALETGSHSPAFVQLALPSVRVGLSGPSSKDVPTGRQPETYHTYTTNTPTTARSIMVAGELGTA 1259

  Fly   980 KSIPQSQ---------------------------------------------------------- 986
            :.:|.||                                                          
  Rat  1260 RVVPTSQYDCLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQR 1324

  Fly   987 ----PVTETN----NHSVAT-----------------------------------------IKDT 1002
                |..||:    .|:..|                                         |.|.
  Rat  1325 VCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGALIPDA 1389

  Fly  1003 DPMDDIIEQ----------LDGAGDLLKLS---------------ESEGQH-------------- 1028
            .|....:|.          ...||..|..|               |:...|              
  Rat  1390 TPSHGTLESGLEVVAVPTVTSQAGATLLASFSTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD 1454

  Fly  1029 ----GSEENE---NNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVN 1086
                .|::.|   ..|::...:||||:.|...:..| ||...:....||. ...|..:||.|:..
  Rat  1455 PPPAASDQGEVASTQGDSTNITSASAITTTVSSTLP-RAVTTVTQSTPVP-GPSVPNISSLTETT 1517

  Fly  1087 ETAIVS----------------------------------------------------------G 1093
            ..|:.|                                                          |
  Rat  1518 PGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMG 1582

  Fly  1094 DTIESLKMSE----KENDDVKSMGEKSILSDDC------------HQPTTSE------------- 1129
            ::.|.|..|:    :...|:.|.|:.|.:.:..            .|||.||             
  Rat  1583 ESAEVLSASQTPELQAAVDLSSTGDPSSVQEPTTSAVVATVVVQPPQPTQSEVDQLSLPQELMAE 1647

  Fly  1130 -----------------------TEAATILTTIKSAEALV-------------------LETAEI 1152
                                   .|||......:.|:||.                   ::|:|.
  Rat  1648 AQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEA 1712

  Fly  1153 RKDHTGCTIGSLKENQDENKK---------------FKQRQESSPSQNIHQFQ------------ 1190
            ....|...:|.|.....|.:.               .:|:|:...:|...|.|            
  Rat  1713 AAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPAD 1777

  Fly  1191 -----NVDGSQLEALASA-----ALLQAATSDT-----TALALKELIERPESETNTRSSNIAEIQ 1240
                 :::.:.|..||||     |||.:..:::     |.:|.:.::....::... ::.:.|: 
  Rat  1778 SLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQA-AATLTEV- 1840

  Fly  1241 QNNVQSTLAV---VVPNTS----QNENQKWHTVGVFKDLSHTVTSYI---DSNCISDSFFDGIDV 1295
            .|.::| |.|   :.|..|    :.||| |..|||.|..|..||.|.   |....||.     |.
  Rat  1841 ANGIES-LGVKPDLPPPPSKAPIKKENQ-WFDVGVIKGTSVMVTHYFLPPDDAVQSDD-----DS 1898

  Fly  1296 DNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGA 1360
            ..:||:::..:..|:|||||:||::.||:||||.:.|||:||||||||||||.||||||. .:||
  Rat  1899 GTVPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKS-PDGA 1962

  Fly  1361 HLTWEPPPAQKTKEIIEYSVYLAVKPT--AKDKALSTP-QLAFVRVYVGAANQCTVPNASLSNAH 1422
            |||||||.....| |||||||||::.:  :.:...||| ||||:|||.|.:..|.|.::||||||
  Rat  1963 HLTWEPPSVTSGK-IIEYSVYLAIQSSQASGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAH 2026

  Fly  1423 VDCSNKPAIIFRIAARNQKGYGPATQVRWLQD---------PAAAKQHTPTVTPNLKRGPEKS 1476
            :|.:.||||||||||||:|||||||||||||:         ||:.:   |..:|.:|..|:||
  Rat  2027 IDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKR---PMSSPEMKSAPKKS 2086

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 32/36 (89%)
KELCH repeat 74..115 CDD:276965 34/40 (85%)
KELCH repeat 123..175 CDD:276965 33/51 (65%)
Kelch_3 132..184 CDD:290151 34/51 (67%)
Kelch_5 175..221 CDD:290565 36/48 (75%)
KELCH repeat 178..239 CDD:276965 40/63 (63%)
Kelch_3 260..305 CDD:290151 32/44 (73%)
KELCH repeat 297..360 CDD:276965 44/63 (70%)
Kelch_3 306..371 CDD:290151 47/65 (72%)
FN3 <1307..1338 CDD:238020 18/30 (60%)
FN3 1344..1448 CDD:238020 67/106 (63%)
Hcfc1XP_006229655.1 PLN02153 12..330 CDD:177814 214/315 (68%)
Kelch_1 32..69 CDD:279660 32/36 (89%)
KELCH repeat 33..80 CDD:276965 36/46 (78%)
KELCH repeat 84..134 CDD:276965 31/49 (63%)
Kelch_3 91..145 CDD:290151 35/53 (66%)
Kelch_5 134..179 CDD:290565 35/44 (80%)
KELCH repeat 137..196 CDD:276965 40/62 (65%)
KELCH repeat 200..253 CDD:276965 30/52 (58%)
Kelch_3 215..263 CDD:290151 32/47 (68%)
KELCH repeat 255..319 CDD:276965 44/63 (70%)
Kelch_3 264..330 CDD:290151 47/65 (72%)
Kelch_5 319..>351 CDD:290565 27/31 (87%)
KELCH repeat 322..367 CDD:276965 37/44 (84%)
FN3 <1912..1941 CDD:238020 18/28 (64%)
FN3 1947..2052 CDD:238020 67/106 (63%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 108 1.000 Domainoid score I6338
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 659 1.000 Inparanoid score I736
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D202078at33208
OrthoFinder 1 1.000 - - FOG0002961
OrthoInspector 1 1.000 - - oto96657
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR46003
Phylome 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2316
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
99.160

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