Protein Alignment Hcf and Hcfc1

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_006229655.1
• Gene: Hcfc1 / 363519
• RGDID: 1563804
• Length: 2091
• Species: Rattus norvegicus
• Alignment Length: 2143
• Identity: 641/2143 - (29%)
• Similarity: 881/2143 - (41%)
• Gaps: 799/2143 - (37%)

  Fly    59 RWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGC 123
            |||||:..:||.|||||||||:.||||:|||||||||||||||||||.||||::|.::||:|.||
  Rat    18 RWKRVVGWSGPVPRPRHGHRAVAIKELIVVFGGGNEGIVDELHVYNTATNQWFIPAVRGDIPPGC 82

  Fly   124 AAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGE 188
            ||||||.:|||:.|||||:|||||||:||||||::|||:::..::|.:|..|||||||||::||.
  Rat    83 AAYGFVCDGTRLLVFGGMVEYGKYSNDLYELQASRWEWKRLKAKTPKNGPPPCPRLGHSFSLVGN 147

  Fly   189 KIFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISF 250
            |.:|||||||:|:|||||||:||||||||:.|   ||.:    |.:|.|||..||||||||.:.:
  Rat   148 KCYLFGGLANDSEDPKNNIPRYLNDLYILELRPGSGVVA----WDIPITYGVLPPPRESHTAVVY 208

  Fly   251 ATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGW 315
            ..|.|....|:||||||||||||||.|:.:::||:||..||.|||||||||:|.|||||||||||
  Rat   209 TEKDNKKSKLVIYGGMSGCRLGDLWTLDIETLTWNKPSLSGVAPLPRSLHSATTIGNKMYVFGGW 273

  Fly   316 VPLVINDSK-STTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWS 379
            ||||::|.| :|.|:|||||||||.|:|:||.||.:.:||:|:|:||||||||||.|.:|||:||
  Rat   274 VPLVMDDVKVATHEKEWKCTNTLACLNLDTMAWETILMDTLEDNIPRARAGHCAVAINTRLYIWS 338

  Fly   380 GRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIEQP 444
            ||||||||||||||||||||||..||....:|.||||:|::||:||.|...|.:|:||:||.:.|
  Rat   339 GRDGYRKAWNNQVCCKDLWYLETEKPPPPARVQLVRANTNSLEVSWGAVATADSYLLQLQKYDIP 403

  Fly   445 LN--TSSKLLSN------------------------------NIVQQGTPTSAETSGINISANRS 477
            ..  |::....|                              .:|.|.......|:.|.:.....
  Rat   404 ATAATATSPTPNPVPSVPANPPKSPAPAAAAPAVQPLTQVGITLVPQAAAAPPSTTTIQVLPTVP 468

  Fly   478 GSALGLGVEATS----TVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSS 538
            ||::.:...|.:    .|||:             |..|.:....|.:|    .|||:|.|.|:
  Rat   469 GSSISVPTAARTQGVPAVLKV-------------TGPQATTGTPLVTM----RPASQAGKAPV-- 514

  Fly   539 GGGTTFNLSTSVASVHP----QISVISSTAAVTGNDT-ASPSGAINSILQKFRPVVTAVRTSTTT 598
               |..:|..||..|.|    |.:||.|...::|... |:.:.|...|.....|.|.:|...||.
  Rat   515 ---TVTSLPASVRMVVPTQSAQGTVIGSNPQMSGMAALAAAAAATQKIPPSSAPTVLSVPAGTTI 576

  Fly   599 AVSIAT---STSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSA 660
            ..::|.   :|:.|.:|:|.|    :.|:.|:.:| |::.:..|    ::.:|.:|..|..:...
  Rat   577 VKTVAVTPGTTTLPATVKVAS----SPVMVSNPAT-RMLKTAAA----QVGTSVSSAANTSTRPI 632

  Fly   661 INILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTA 725
            |.:.|:....||.|:|   ..||.:||    :.|.:||   |:.......|...:..|.||
  Rat   633 ITVHKSGTVTVAQQAQ---VVTTVVGG----VTKTITL---VKSPISVPGGSALISNLGKV---- 683

  Fly   726 SKGTPPHGISI--ANPHLASGITQIQGSTVPGSQI---QKPIVSGNVLKL--------------- 770
                    :|:  ..|...|.:|. |.||.|.:||   :.|:.:|.:|||
  Rat   684 --------MSVVQTKPVQTSAVTG-QASTGPVTQIIQTKGPLPAGTILKLVTSADGKPTTIITTT 739

  Fly   771 ----------------VSPHTMAGG-----KLIMKNSNILQMGK---------------VTPNVM 799
                            |||.|...|     |.|..::.|.|.|.               :|..||
  Rat   740 QASGAGTKPTILGISSVSPSTTKPGTTTIIKTIPMSAIITQAGATGVTSSPGIKSPITIITTKVM 804

  Fly   800 ---GGKPAFVIT---------NKQG-------------------TPLGNQQII------------ 821
               .|.||.:||         .:||                   .|:|..:::
  Rat   805 TSGTGAPAKIITAVPKIATGHGQQGVTQVVLKGAPGQPGTILRTVPMGGVRLVTPVTVSAVKPAV 869

  Fly   822 ---IV--TTGGNVRSVPTSTVMTSAGGSASGTNIVS-----------------IVNSTSTTPSPL 864
               :|  |||.......|.||.||..|:.:.:...|                 ::|.|:.|.|..
  Rat   870 TTLVVKGTTGVTTLGTVTGTVSTSLAGAGAHSTSASLATPITTLGTIATLSSQVINPTAITVSAA 934

  Fly   865 Q----ALSG---------------QKTLISNQSGVK----------MLRNISSVQASSSMAF--- 897
            |    |..|               |.|||:..|||:          :|.:.::.|.::::..
  Rat   935 QTTLTAAGGLTTPTITMQPVSQPTQVTLITAPSGVEAQPVHDLPVSILASPTTEQPTATVTIADS 999

  Fly   898 --GQKQSGTPI-----------------------------------------HQKTALYI----- 914
              |..|.||..                                         .|:.|..:
  Rat  1000 GQGDVQPGTVTLVCSNPPCETHETGTTNTATTTVVANLGGHPQPTQVQFVCDRQEAAASLVTSAV 1064

  Fly   915 ---GGKAVTVMS-----------TNTSMAASGN-------------------------------- 933
               .|..|.|.|           |||:..|:.|
  Rat  1065 GQQNGNVVRVCSNPPCETHETGTTNTATTATSNMAGQHGCSNPPCETHETGTTSTATTAMSSMGT 1129

  Fly   934 ----------------KVMVLPG--------------TSSNNSPATTTALSA-----------RK 957
                            ::.|.||              |...|..:||..:.|           |.
  Rat  1130 GQQRDARRATNTPTVVRITVAPGALERAQGTVKPPCQTQQTNMTSTTMTVQATGAPCSAGPLLRP 1194

  Fly   958 SFVFNAGG-SPRTVTLATKSI------------------------------------------NA 979
            |.....|. ||..|.||..|:                                          .|
  Rat  1195 SVALETGSHSPAFVQLALPSVRVGLSGPSSKDVPTGRQPETYHTYTTNTPTTARSIMVAGELGTA 1259

  Fly   980 KSIPQSQ---------------------------------------------------------- 986
            :.:|.||
  Rat  1260 RVVPTSQYDCLQASSPSSTMTMTALEALLCPSATVTQVCSNPPCETHETGTTNTATTSNAGSAQR 1324

  Fly   987 ----PVTETN----NHSVAT-----------------------------------------IKDT 1002
                |..||:    .|:..|                                         |.|.
  Rat  1325 VCSNPPCETHETGTTHTATTATSNGGAGQPEGGQQPASGHPCETHQTTSTGTTMSVSVGALIPDA 1389

  Fly  1003 DPMDDIIEQ----------LDGAGDLLKLS---------------ESEGQH-------------- 1028
            .|....:|.          ...||..|..|               |:...|
  Rat  1390 TPSHGTLESGLEVVAVPTVTSQAGATLLASFSTQRVCSNPPCETHETGTTHTATTVTSNMSSNQD 1454

  Fly  1029 ----GSEENE---NNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVN 1086
                .|::.|   ..|::...:||||:.|...:..| ||...:....||. ...|..:||.|:..
  Rat  1455 PPPAASDQGEVASTQGDSTNITSASAITTTVSSTLP-RAVTTVTQSTPVP-GPSVPNISSLTETT 1517

  Fly  1087 ETAIVS----------------------------------------------------------G 1093
            ..|:.|                                                          |
  Rat  1518 PGALTSEVPIPATITVTIANTETSDMPFSAVDILQPPEELQVSPGPRQQLPPRQLLQSASTPLMG 1582

  Fly  1094 DTIESLKMSE----KENDDVKSMGEKSILSDDC------------HQPTTSE------------- 1129
            ::.|.|..|:    :...|:.|.|:.|.:.:..            .|||.||
  Rat  1583 ESAEVLSASQTPELQAAVDLSSTGDPSSVQEPTTSAVVATVVVQPPQPTQSEVDQLSLPQELMAE 1647

  Fly  1130 -----------------------TEAATILTTIKSAEALV-------------------LETAEI 1152
                                   .|||......:.|:||.                   ::|:|.
  Rat  1648 AQAGTTTLMVTGLTPEELAVTAAAEAAAQAAATEEAQALAIQAVLQAAQQAVMAGTGEPMDTSEA 1712

  Fly  1153 RKDHTGCTIGSLKENQDENKK---------------FKQRQESSPSQNIHQFQ------------ 1190
            ....|...:|.|.....|.:.               .:|:|:...:|...|.|
  Rat  1713 AAAVTQAELGHLSAEGQEGQATTIPIVLTQQELAALVQQQQQLQEAQAQAQQQHHLPTEALAPAD 1777

  Fly  1191 -----NVDGSQLEALASA-----ALLQAATSDT-----TALALKELIERPESETNTRSSNIAEIQ 1240
                 :::.:.|..||||     |||.:..:::     |.:|.:.::....::... ::.:.|:
  Rat  1778 SLNDPSIESNCLNELASAVPSTVALLPSTATESLAPSNTFVAPQPVVVASPAKMQA-AATLTEV- 1840

  Fly  1241 QNNVQSTLAV---VVPNTS----QNENQKWHTVGVFKDLSHTVTSYI---DSNCISDSFFDGIDV 1295
            .|.::| |.|   :.|..|    :.||| |..|||.|..|..||.|.   |....||.     |.
  Rat  1841 ANGIES-LGVKPDLPPPPSKAPIKKENQ-WFDVGVIKGTSVMVTHYFLPPDDAVQSDD-----DS 1898

  Fly  1296 DNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGA 1360
            ..:||:::..:..|:|||||:||::.||:||||.:.|||:||||||||||||.||||||. .:||
  Rat  1899 GTVPDYNQLKKQELQPGTAYKFRVAGINACGRGPFSEISAFKTCLPGFPGAPCAIKISKS-PDGA 1962

  Fly  1361 HLTWEPPPAQKTKEIIEYSVYLAVKPT--AKDKALSTP-QLAFVRVYVGAANQCTVPNASLSNAH 1422
            |||||||.....| |||||||||::.:  :.:...||| ||||:|||.|.:..|.|.::||||||
  Rat  1963 HLTWEPPSVTSGK-IIEYSVYLAIQSSQASGEPKSSTPAQLAFMRVYCGPSPSCLVQSSSLSNAH 2026

  Fly  1423 VDCSNKPAIIFRIAARNQKGYGPATQVRWLQD---------PAAAKQHTPTVTPNLKRGPEKS 1476
            :|.:.||||||||||||:|||||||||||||:         ||:.:   |..:|.:|..|:||
  Rat  2027 IDYTTKPAIIFRIAARNEKGYGPATQVRWLQETSKDSSGTKPASKR---PMSSPEMKSAPKKS 2086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	206/307 (67%)
		KELCH repeat	74..115	CDD:276965	34/40 (85%)
		KELCH repeat	123..175	CDD:276965	33/51 (65%)
		KELCH repeat	178..239	CDD:276965	40/63 (63%)
		KELCH repeat	297..360	CDD:276965	44/63 (70%)
		FN3	<1307..>1381	CDD:442628	50/73 (68%)
		FN3	<1307..1338	CDD:238020	18/30 (60%)
		FN3	1344..1448	CDD:238020	67/106 (63%)
Hcfc1	XP_006229655.1	NanM	25..344	CDD:442289	219/322 (68%)
		KELCH repeat	33..80	CDD:276965	36/46 (78%)
		KELCH repeat	84..134	CDD:276965	31/49 (63%)
		KELCH repeat	137..196	CDD:276965	40/62 (65%)
		KELCH repeat	200..253	CDD:276965	30/52 (58%)
		KELCH repeat	255..319	CDD:276965	44/63 (70%)
		KELCH repeat	322..367	CDD:276965	37/44 (84%)
		COG4625	444..>950	CDD:443664	126/559 (23%)
		PRK10263	<1473..>1647	CDD:236669	29/175 (17%)
		FN3	<1912..1941	CDD:238020	18/28 (64%)