DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcf and CG12081

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	96/417 - (23%)
Similarity:	170/417 - (40%)	Gaps:	77/417 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DGHQLDSNLTGFRWKRV---LNPTGPQ------PRPRHGHRAINIKELMVVFGGGN-EGIVDELH 101
            |.|.|:::.  .||..|   |:..|..      |..|:||..:..|:.:.::||.| |.:.:.|:
  Fly    44 DVHALNAHT--MRWTLVPQQLDDAGVPLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLY 106

  Fly   102 VYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMI-EYGKYSNELYELQATKWEWRKMY 165
            .::..|.||..|.:.|.:|.....:...|.|..|::|||.: |..::|::::.|.....|||  |
  Fly   107 CFDPKTAQWSRPQVTGCLPGARDGHSACVIGNSMYIFGGFVDEINEFSSDVHSLNLDTMEWR--Y 169

  Fly   166 PESPDSGLSPCPRLGH-SFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKW 229
            .::  .|:.|..|..| |.....|::::|||..::.....:....|.:::..||.:     ...|
  Fly   170 VQT--FGVPPSYRDFHASVAYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMK-----TKVW 227

  Fly   230 IVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGC---RLGDLWLLETDSMTWSKPKTSG 291
            ..|.|.|..|..|.||:...:      |..:.::||.:|.   ...||:..:..:..|:..:.:|
  Fly   228 HRPFTAGKVPVGRRSHSMFVY------NKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANG 286

  Fly   292 EAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVE 356
            :||..|....:.::|.:|::|||           |:.|....::..||            ..|.|
  Fly   287 KAPTARRRQCAIVMGTRMFLFGG-----------TSPRSGSSSSPAAV------------SPTQE 328

  Fly   357 ENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHAL 421
            .....|..|....|:....|                  .||..|:....|..:...:|  ..|.|
  Fly   329 TGGAAAAGGVVPPGVALIDY------------------SDLHVLDFEPTLKTLATMVV--LKHQL 373

  Fly   422 ELSWTATTFAA--AYVLQIQKIEQPLN 446
            ::|....:|.:  ..:.|...|.:|:|
  Fly   374 DISGLPRSFRSDLQMLTQPNSISRPIN 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	10/37 (27%)
		KELCH repeat	74..115	CDD:276965	13/41 (32%)
		KELCH repeat	123..175	CDD:276965	14/52 (27%)
		Kelch_3	132..184	CDD:290151	17/53 (32%)
		Kelch_5	175..221	CDD:290565	11/46 (24%)
		KELCH repeat	178..239	CDD:276965	14/61 (23%)
		Kelch_3	260..305	CDD:290151	10/47 (21%)
		KELCH repeat	297..360	CDD:276965	12/62 (19%)
		Kelch_3	306..371	CDD:290151	13/64 (20%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	8/26 (31%)
		Kelch_6	13..60	CDD:290672	6/17 (35%)
		KELCH repeat	78..125	CDD:276965	14/46 (30%)
		Kelch_1	78..117	CDD:279660	12/38 (32%)
		KELCH repeat	128..170	CDD:276965	12/43 (28%)
		Kelch_3	137..188	CDD:290151	17/54 (31%)
		KELCH repeat	180..236	CDD:276965	14/60 (23%)
		Kelch_3	192..248	CDD:290151	14/60 (23%)
		Kelch_5	237..276	CDD:290565	10/44 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9219
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870