DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and Hcfc2

DIOPT Version :10

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_001008358.1 Gene:Hcfc2 / 314704 RGDID:1307385 Length:723 Species:Rattus norvegicus


Alignment Length:1423 Identity:376/1423 - (26%)
Similarity:503/1423 - (35%) Gaps:719/1423 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCA 124
            |:||.:.|||.||.||||||:.|:|||::||||||||.|||||||||||||::|.::||:|.|||
  Rat     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTVTNQWFLPAVRGDIPPGCA 73

  Fly   125 AYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEK 189
            |:|||.:|||:.|||||:|||:||||||||||::|.|:|:.|:.|.|||.|||||||||::.|.|
  Rat    74 AHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPQPPPSGLPPCPRLGHSFSLYGNK 138

  Fly   190 IFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISFA 251
            .:||.||||||:|..||:|:||||.|.|:.:   ||..    |.||.|.|..|.||||||.:.:.
  Rat   139 CYLFAGLANESEDSNNNVPRYLNDFYELELQHGSGVVG----WSVPATKGTVPSPRESHTAVIYC 199

  Fly   252 TKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWV 316
            .:.:|:..:.::|||.|.||.|||.|:.::|:||||:|.|..|||||||::::||||||:|||||
  Rat   200 KRDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWV 264

  Fly   317 P-LVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEE---NVPRARAGHCAVGIQSRLYV 377
            | ...|...|..:.||:||::.:.|:|:|..|..:..|:.|:   :.||.|||||||.|.:|||.
  Rat   265 PHKGENTENSPHDCEWRCTSSFSYLNLDTAEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYF 329

  Fly   378 WSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIE 442
            |||||||:||.|:||||||||||:..||....:|.|::|:|::..:.|........|:||     
  Rat   330 WSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVPTVEGYLLQ----- 389

  Fly   443 QPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPE 507
              |||                                                            
  Rat   390 --LNT------------------------------------------------------------ 392

  Fly   508 TNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTA 572
                    ||....:.|.:.|:     |.:.||.|         ..|.|.|              
  Rat   393 --------DLTHQAASPDASAA-----PNTLGGRT---------DPHRQGS-------------- 421

  Fly   573 SPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSV 637
                  ||||.                    .|.|||.                           
  Rat   422 ------NSILH--------------------NSVSDPA--------------------------- 433

  Fly   638 TASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNV 702
                            ||                                               
  Rat   434 ----------------NC----------------------------------------------- 435

  Fly   703 QLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNV 767
                                      |.|.                                   
  Rat   436 --------------------------TKPE----------------------------------- 439

  Fly   768 LKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSV 832
                  ||                                             .:...|.:::|.
  Rat   440 ------HT---------------------------------------------AVAARGMSLKSK 453

  Fly   833 PTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAF 897
            |.|..                                                     |.||:| 
  Rat   454 PDSRA-----------------------------------------------------ADSSVA- 464

  Fly   898 GQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFN 962
                    :|...|                           |.||:|||                
  Rat   465 --------LHSPLA---------------------------PNTSNNNS---------------- 478

  Fly   963 AGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQ 1027
                                                               ...|:|..||    
  Rat   479 ---------------------------------------------------CMADMLWKSE---- 488

  Fly  1028 HGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVS 1092
                                                      ||.|                   
  Rat   489 ------------------------------------------VDEI------------------- 492

  Fly  1093 GDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHT 1157
                                         |..|.|.          |...||           |.
  Rat   493 -----------------------------CALPATK----------ISRVEA-----------HA 507

  Fly  1158 GCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELI 1222
            ..|            .|.:...|:|                    .|:|:|              
  Rat   508 AAT------------PFSKETPSNP--------------------VAILKA-------------- 526

  Fly  1223 ERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSY--IDSNCI 1285
                                                  ::|..||:||:.:..|:.:  :.....
  Rat   527 --------------------------------------EQWCDVGIFKNNTALVSQFYLLPKGKQ 553

  Fly  1286 SDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAI 1350
            |.|.....||   ||:|...:.:|.|||.|:||::|||.||.|.:.::|.||||:||||||||.:
  Rat   554 SMSKVGNADV---PDYSLLKKQDLVPGTVYKFRVAAINGCGIGPFSKLSEFKTCIPGFPGAPSTV 615

  Fly  1351 KISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPN 1415
            :|||:| ||.||:|| ||...:..|:|||.|||:: ||:.:. :..||.|:|:|.|....|.|..
  Rat   616 RISKNV-EGIHLSWE-PPTSPSGNILEYSAYLAIR-TAQVQD-NPSQLVFMRIYCGLKTSCIVTA 676

  Fly  1416 ASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVTPNLKRGP 1473
            ..|:|||:|.:::|||:|||:|:|:|||||||||||||.             |.|:.|
  Rat   677 GQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQG-------------NSKKAP 721

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 PLN02193 <59..363 CDD:177844 173/309 (56%)
KELCH repeat 74..115 CDD:276965 32/40 (80%)
KELCH repeat 123..175 CDD:276965 35/51 (69%)
KELCH repeat 178..239 CDD:276965 33/63 (52%)
KELCH repeat 297..360 CDD:276965 28/66 (42%)
FN3 <1307..>1381 CDD:442628 42/73 (58%)
FN3 <1307..1338 CDD:238020 15/30 (50%)
FN3 1344..1448 CDD:238020 53/103 (51%)
Hcfc2NP_001008358.1 NanM 14..332 CDD:442289 182/321 (57%)
KELCH repeat 23..69 CDD:276965 34/45 (76%)
Kelch 1 34..79 33/44 (75%)
Kelch 2 83..130 32/46 (70%)
KELCH repeat 127..186 CDD:276965 33/62 (53%)
KELCH repeat 190..241 CDD:276965 23/50 (46%)
Kelch 3 207..255 25/47 (53%)
KELCH repeat 245..312 CDD:276965 28/66 (42%)
Kelch 4 257..305 19/47 (40%)
Kelch_5 312..355 CDD:433528 33/42 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 398..472 33/418 (8%)
FN3 <549..603 CDD:238020 22/56 (39%)
FN3 609..709 CDD:238020 53/103 (51%)

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