DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcf and Klhdc1

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_006240231.1	Gene:	Klhdc1 / 314190	RGDID:	1308211	Length:	406	Species:	Rattus norvegicus

Alignment Length:	439	Identity:	105/439 - (23%)
Similarity:	183/439 - (41%)	Gaps:	118/439 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 RHGHRAINIKELMVVFGG-----GNEGIV--DELHVYNTVTNQWYVPVLKGDVPNGCA-AYGFVV 130
            |.||.|:.....:.|:||     .||..:  ||:..|:..:..|.:.:::|::|...: :.|..:
  Rat    13 RSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEIWTYDVDSGLWKMHLMEGELPPSMSGSCGACI 77

  Fly   131 EGTRMFVFGGMIEYGKYSNELY--ELQAT--KWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIF 191
            .| |::||||..:.| |||.||  :|:..  .:.|.|:   :...|..|.||...|..:..:::.
  Rat    78 NG-RLYVFGGYDDKG-YSNRLYFVDLRTRDGTYIWEKI---TKFEGQPPTPRDKLSCWVYKDRLI 137

  Fly   192 LFGGL-------------ANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPP-PR 242
            .|||.             .:::...:.....:.||:::.||:     ...|..|:..|..|| ||
  Rat   138 YFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTK-----TRTWSQPEIKGGVPPQPR 197

  Fly   243 ESHTGISFATKSNGNLNLLIYGG-MSGCRLGDLWLLETDSMTWS-KPKTSGEAPLPRSLHSSTMI 305
            .:|:......|.      .::|| :...|:.||..|..|:..|| :...:||:|..||.|:.|.|
  Rat   198 AAHSCAVLGNKG------YVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAI 256

  Fly   306 G-NKMYVFGGW----VPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVP--RAR 363
            . :|:::|||.    :||  :|.       |       :.::.|..|:.:      .::|  |.|
  Rat   257 ADDKLFLFGGLSADNIPL--SDG-------W-------IHNIITNCWKQL------RHLPYTRPR 299

  Fly   364 AGHCA-VGIQSRLYVWSG-RD-------GYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTH 419
            ..|.| :|.::.:.|:.| :|       |:         |.||...: ::|...::..|.....:
  Rat   300 LWHTACLGKENEIMVFGGSKDNLLFLDTGH---------CNDLLIFQ-TQPYSLLRSCLDCIGKN 354

  Fly   420 ALELS--------------------WTATTFAAAYVLQIQKIE----QP 444
            |:.|.                    |||..:....  :|||.|    ||
  Rat   355 AIILKSQISLLPPKLLQQVFQKITFWTAANYRKEQ--RIQKGETENKQP 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	12/42 (29%)
		KELCH repeat	74..115	CDD:276965	13/47 (28%)
		KELCH repeat	123..175	CDD:276965	17/56 (30%)
		Kelch_3	132..184	CDD:290151	20/55 (36%)
		Kelch_5	175..221	CDD:290565	11/58 (19%)
		KELCH repeat	178..239	CDD:276965	12/73 (16%)
		Kelch_3	260..305	CDD:290151	16/46 (35%)
		KELCH repeat	297..360	CDD:276965	15/67 (22%)
		Kelch_3	306..371	CDD:290151	15/72 (21%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
Klhdc1	XP_006240231.1	PHA03098	<13..162	CDD:222983	39/153 (25%)
		KELCH repeat	13..66	CDD:276965	14/52 (27%)
		KELCH repeat	70..120	CDD:276965	17/54 (31%)
		KELCH repeat	124..194	CDD:276965	12/74 (16%)
		PLN02153	183..>323	CDD:177814	45/167 (27%)
		KELCH repeat	197..235	CDD:276965	10/43 (23%)
		KELCH repeat	248..295	CDD:276965	15/68 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339340
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840