DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hcf and HCFC2

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_037452.1 Gene:HCFC2 / 29915 HGNCID:24972 Length:792 Species:Homo sapiens


Alignment Length:1403 Identity:384/1403 - (27%)
Similarity:537/1403 - (38%) Gaps:637/1403 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCA 124
            |:||.:.|||.||.||||||:.|:|||::||||||||.||||||||.||||::|.::||:|.|||
Human     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTATNQWFLPAVRGDIPPGCA 73

  Fly   125 AYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEK 189
            |:|||.:|||:.|||||:|||:||||||||||::|.|:|:.|..|.|||.|||||||||::.|.|
Human    74 AHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPHPPPSGLPPCPRLGHSFSLYGNK 138

  Fly   190 IFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISFA 251
            .:|||||||||:|..||:|:||||.|.|:.:   ||..    |.:|.|.|..|.||||||.:.:.
Human   139 CYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVG----WSIPVTKGVVPSPRESHTAVIYC 199

  Fly   252 TKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWV 316
            .|.:|:..:.::|||.|.||.|||.|:.::|:||||:|.|..|||||||::::||||||:|||||
Human   200 KKDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWV 264

  Fly   317 P-LVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEE---NVPRARAGHCAVGIQSRLYV 377
            | ...|...|..:.||:||::.:.|:|:|..|..:..|:.|:   :.||.|||||||.|.:|||.
Human   265 PHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYF 329

  Fly   378 WSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIE 442
            |||||||:||.|:||||||||||:..||....:|.|::|:|::..:.|...:....|:||     
Human   330 WSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVSTVEGYLLQ----- 389

  Fly   443 QPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPE 507
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   508 TNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTA 572
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   573 SPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSV 637
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   638 TASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNV 702
                                      |.|.||..|..|..::                   |||:
Human   390 --------------------------LSTDLPYQAASSDSSA-------------------APNM 409

  Fly   703 QLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNV 767
            |                             |:.: :||.       |||                
Human   410 Q-----------------------------GVRM-DPHR-------QGS---------------- 421

  Fly   768 LKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSV 832
                                    ..:.||                                   
Human   422 ------------------------NNIVPN----------------------------------- 427

  Fly   833 PTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAF 897
                            :|...:|||.|     :..:.::|.:.|:...|.|.:.:::        
Human   428 ----------------SINDTINSTKT-----EQPATKETSMKNKPDFKALTDSNAI-------- 463

  Fly   898 GQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFN 962
                          ||                         |..:||.|                
Human   464 --------------LY-------------------------PSLASNAS---------------- 473

  Fly   963 AGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQ 1027
                                       ..|:|.|                    |:|:.:|    
Human   474 ---------------------------NHNSHVV--------------------DMLRKNE---- 487

  Fly  1028 HGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVS 1092
                                        ||..:.|..|:...:|:         .|.:.||::.|
Human   488 ----------------------------GPHTSANVGVLSSCLDV---------RTVIPETSVSS 515

  Fly  1093 GDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHT 1157
                                             |.|.|:......|||:..:..  ...:.||.|
Human   516 ---------------------------------TVSSTQTMVTQQTIKTESSST--NGAVVKDET 545

  Fly  1158 GCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELI 1222
            ..|..|.|...||.       .:.|:..|        |::|..|:|.                  
Human   546 SLTTFSTKSEVDET-------YALPATKI--------SRVETHATAT------------------ 577

  Fly  1223 ERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSY--IDSNCI 1285
              |.|: .|.|:.:|.::..                 .::|..||:||:.:..|:.:  :.....
Human   578 --PFSK-ETPSNPVATVKAG-----------------ERQWCDVGIFKNNTALVSQFYLLPKGKQ 622

  Fly  1286 SDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAI 1350
            |.|.....||   ||:|...:.:|.|||.||||::|||.||.|.:.:||.||||:|||||||||:
Human   623 SISKVGNADV---PDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTCIPGFPGAPSAV 684

  Fly  1351 KISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPN 1415
            :|||:| ||.||:|| ||...:..|:|||.|||:: ||:.:. :..||.|:|:|.|....|.|..
Human   685 RISKNV-EGIHLSWE-PPTSPSGNILEYSAYLAIR-TAQIQD-NPSQLVFMRIYCGLKTSCIVTA 745

  Fly  1416 ASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQ 1453
            ..|:|||:|.:::|||:|||:|:|:|||||||||||||
Human   746 GQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQ 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 28/36 (78%)
KELCH repeat 74..115 CDD:276965 31/40 (78%)
KELCH repeat 123..175 CDD:276965 35/51 (69%)
Kelch_3 132..184 CDD:290151 37/51 (73%)
Kelch_5 175..221 CDD:290565 30/48 (63%)
KELCH repeat 178..239 CDD:276965 33/63 (52%)
Kelch_3 260..305 CDD:290151 24/44 (55%)
KELCH repeat 297..360 CDD:276965 28/66 (42%)
Kelch_3 306..371 CDD:290151 32/68 (47%)
FN3 <1307..1338 CDD:238020 17/30 (57%)
FN3 1344..1448 CDD:238020 54/103 (52%)
HCFC2NP_037452.1 PLN02193 <2..262 CDD:177844 154/256 (60%)
KELCH repeat 23..69 CDD:276965 33/45 (73%)
Kelch 1 34..79 32/44 (73%)
Kelch 2 83..130 32/46 (70%)
KELCH repeat 127..186 CDD:276965 33/62 (53%)
Kelch_3 136..198 CDD:290151 34/65 (52%)
KELCH repeat 190..241 CDD:276965 24/50 (48%)
Kelch 3 207..255 25/47 (53%)
Kelch_3 207..253 CDD:290151 24/45 (53%)
KELCH repeat 245..312 CDD:276965 28/66 (42%)
Kelch_3 254..323 CDD:290151 32/68 (47%)
Kelch 4 257..303 18/45 (40%)
Kelch_5 312..354 CDD:290565 33/41 (80%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..447 18/199 (9%)
FN3 <618..672 CDD:238020 24/56 (43%)
FN3 678..778 CDD:238020 54/103 (52%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145646
Domainoid 1 1.000 64 1.000 Domainoid score I10223
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D202078at33208
OrthoFinder 1 1.000 - - FOG0002961
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR46003
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 1 1.000 - - X2316
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.980

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