DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and HCFC2

DIOPT Version :10

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_037452.1 Gene:HCFC2 / 29915 HGNCID:24972 Length:792 Species:Homo sapiens


Alignment Length:1403 Identity:384/1403 - (27%)
Similarity:537/1403 - (38%) Gaps:637/1403 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCA 124
            |:||.:.|||.||.||||||:.|:|||::||||||||.||||||||.||||::|.::||:|.|||
Human     9 WRRVSSFTGPVPRARHGHRAVAIRELMIIFGGGNEGIADELHVYNTATNQWFLPAVRGDIPPGCA 73

  Fly   125 AYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEK 189
            |:|||.:|||:.|||||:|||:||||||||||::|.|:|:.|..|.|||.|||||||||::.|.|
Human    74 AHGFVCDGTRILVFGGMVEYGRYSNELYELQASRWLWKKVKPHPPPSGLPPCPRLGHSFSLYGNK 138

  Fly   190 IFLFGGLANESDDPKNNIPKYLNDLYILDTR---GVHSHNGKWIVPKTYGDSPPPRESHTGISFA 251
            .:|||||||||:|..||:|:||||.|.|:.:   ||..    |.:|.|.|..|.||||||.:.:.
Human   139 CYLFGGLANESEDSNNNVPRYLNDFYELELQHGSGVVG----WSIPVTKGVVPSPRESHTAVIYC 199

  Fly   252 TKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWV 316
            .|.:|:..:.::|||.|.||.|||.|:.::|:||||:|.|..|||||||::::||||||:|||||
Human   200 KKDSGSPKMYVFGGMCGARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWV 264

  Fly   317 P-LVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEE---NVPRARAGHCAVGIQSRLYV 377
            | ...|...|..:.||:||::.:.|:|:|..|..:..|:.|:   :.||.|||||||.|.:|||.
Human   265 PHKGENTETSPHDCEWRCTSSFSYLNLDTTEWTTLVSDSQEDKKNSRPRPRAGHCAVAIGTRLYF 329

  Fly   378 WSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAYVLQIQKIE 442
            |||||||:||.|:||||||||||:..||....:|.|::|:|::..:.|...:....|:||     
Human   330 WSGRDGYKKALNSQVCCKDLWYLDTEKPPAPSQVQLIKATTNSFHVKWDEVSTVEGYLLQ----- 389

  Fly   443 QPLNTSSKLLSNNIVQQGTPTSAETSGINISANRSGSALGLGVEATSTVLKLEKESLQLSGCQPE 507
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   508 TNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTSVASVHPQISVISSTAAVTGNDTA 572
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   573 SPSGAINSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSV 637
                                                                             
Human   390 ----------------------------------------------------------------- 389

  Fly   638 TASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNV 702
                                      |.|.||..|..|..::                   |||:
Human   390 --------------------------LSTDLPYQAASSDSSA-------------------APNM 409

  Fly   703 QLQFVKTSGGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQIQGSTVPGSQIQKPIVSGNV 767
            |                             |:.: :||.       |||                
Human   410 Q-----------------------------GVRM-DPHR-------QGS---------------- 421

  Fly   768 LKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSV 832
                                    ..:.||                                   
Human   422 ------------------------NNIVPN----------------------------------- 427

  Fly   833 PTSTVMTSAGGSASGTNIVSIVNSTSTTPSPLQALSGQKTLISNQSGVKMLRNISSVQASSSMAF 897
                            :|...:|||.|     :..:.::|.:.|:...|.|.:.:::        
Human   428 ----------------SINDTINSTKT-----EQPATKETSMKNKPDFKALTDSNAI-------- 463

  Fly   898 GQKQSGTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFN 962
                          ||                         |..:||.|                
Human   464 --------------LY-------------------------PSLASNAS---------------- 473

  Fly   963 AGGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQ 1027
                                       ..|:|.|                    |:|:.:|    
Human   474 ---------------------------NHNSHVV--------------------DMLRKNE---- 487

  Fly  1028 HGSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVS 1092
                                        ||..:.|..|:...:|:         .|.:.||::.|
Human   488 ----------------------------GPHTSANVGVLSSCLDV---------RTVIPETSVSS 515

  Fly  1093 GDTIESLKMSEKENDDVKSMGEKSILSDDCHQPTTSETEAATILTTIKSAEALVLETAEIRKDHT 1157
                                             |.|.|:......|||:..:..  ...:.||.|
Human   516 ---------------------------------TVSSTQTMVTQQTIKTESSST--NGAVVKDET 545

  Fly  1158 GCTIGSLKENQDENKKFKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELI 1222
            ..|..|.|...||.       .:.|:..|        |::|..|:|.                  
Human   546 SLTTFSTKSEVDET-------YALPATKI--------SRVETHATAT------------------ 577

  Fly  1223 ERPESETNTRSSNIAEIQQNNVQSTLAVVVPNTSQNENQKWHTVGVFKDLSHTVTSY--IDSNCI 1285
              |.|: .|.|:.:|.::..                 .::|..||:||:.:..|:.:  :.....
Human   578 --PFSK-ETPSNPVATVKAG-----------------ERQWCDVGIFKNNTALVSQFYLLPKGKQ 622

  Fly  1286 SDSFFDGIDVDNLPDFSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAI 1350
            |.|.....||   ||:|...:.:|.|||.||||::|||.||.|.:.:||.||||:|||||||||:
Human   623 SISKVGNADV---PDYSLLKKQDLVPGTGYRFRVAAINGCGIGPFSKISEFKTCIPGFPGAPSAV 684

  Fly  1351 KISKDVKEGAHLTWEPPPAQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPN 1415
            :|||:| ||.||:|| ||...:..|:|||.|||:: ||:.:. :..||.|:|:|.|....|.|..
Human   685 RISKNV-EGIHLSWE-PPTSPSGNILEYSAYLAIR-TAQIQD-NPSQLVFMRIYCGLKTSCIVTA 745

  Fly  1416 ASLSNAHVDCSNKPAIIFRIAARNQKGYGPATQVRWLQ 1453
            ..|:|||:|.:::|||:|||:|:|:|||||||||||||
Human   746 GQLANAHIDYTSRPAIVFRISAKNEKGYGPATQVRWLQ 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 PLN02193 <59..363 CDD:177844 173/309 (56%)
KELCH repeat 74..115 CDD:276965 31/40 (78%)
KELCH repeat 123..175 CDD:276965 35/51 (69%)
KELCH repeat 178..239 CDD:276965 33/63 (52%)
KELCH repeat 297..360 CDD:276965 28/66 (42%)
FN3 <1307..>1381 CDD:442628 45/73 (62%)
FN3 <1307..1338 CDD:238020 17/30 (57%)
FN3 1344..1448 CDD:238020 54/103 (52%)
HCFC2NP_037452.1 NanM 14..332 CDD:442289 182/321 (57%)
KELCH repeat 23..69 CDD:276965 33/45 (73%)
Kelch 1 34..79 32/44 (73%)
Kelch 2 83..130 32/46 (70%)
KELCH repeat 127..186 CDD:276965 33/62 (53%)
KELCH repeat 190..241 CDD:276965 24/50 (48%)
Kelch 3 207..255 25/47 (53%)
KELCH repeat 245..312 CDD:276965 28/66 (42%)
Kelch 4 257..303 18/45 (40%)
Kelch_5 312..355 CDD:433528 33/42 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 399..447 18/199 (9%)
FN3 535..>704 CDD:442628 73/228 (32%)
FN3 <618..672 CDD:238020 24/56 (43%)
FN3 678..778 CDD:238020 54/103 (52%)

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