DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcf and tea3

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_594099.1	Gene:	tea3 / 2542619	PomBaseID:	SPAC6G10.02c	Length:	1125	Species:	Schizosaccharomyces pombe

Alignment Length:	1259	Identity:	241/1259 - (19%)
Similarity:	428/1259 - (33%)	Gaps:	399/1259 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SASDLNSEHIIQAENHSFAN---RISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRA 79
            ::.|:::|.:...|:.|...   |..:...|.:..:..|....|:|:.|        :|.....|
pombe    12 NSQDVSAEQLDVVESGSIDQQNIRAWVVRKVKENDKRTSTNQSFKWEAV--------KPASCLDA 68

  Fly    80 INIKELMVVFGGGNEGI--------VDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMF 136
            .|.|.:.:..|....||        :|...||:....:      ..|.| ....:..|.....::
pombe    69 ANEKFMYLHGGREKSGISNSLFKLDLDSCTVYSHNRGE------DNDSP-ARVGHSIVCSADTIY 126

  Fly   137 VFGG-------MIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFG 194
            :|||       ..|.|  .|.||.......:|..:..:||    .|.||.|||..:|..|:::||
pombe   127 LFGGCDSETDSTFEVG--DNSLYAYNFKSNQWNLVSTQSP----LPSPRTGHSMLLVDSKLWIFG 185

  Fly   195 GLANESDDPKNNIPKYLNDLYILDTRGV------------HSHN------------GKWIVPKTY 235
            |...         .|||||:::.||:||            :::|            ..|..|..:
pombe   186 GECQ---------GKYLNDIHLFDTKGVDRRTQSELKQKANANNVEKANMEFDETDWSWETPFLH 241

  Fly   236 GDSPPPRESHTGISFATKSNGNLNLLIYGGMSGC-RLGDLWLLETDSMTWSKPKTSGEAPLPRSL 299
            ..|||||.:|:    .|...|  .:.::||.:.. .|.||||.:.::::|::.::.|..|.||..
pombe   242 SSSPPPRSNHS----VTLVQG--KIFVHGGHNDTGPLSDLWLFDLETLSWTEVRSIGRFPGPREG 300

  Fly   300 HSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARA 364
            |.:|.|.:.:|::||      .|:|..      ..|.|...:.....|     ..|...:|...:
pombe   301 HQATTIDDTVYIYGG------RDNKGL------ILNELWAFNYSQQRW-----SLVSNPIPILLS 348

  Fly   365 GHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATT 429
            ...:..|.|:              ||.:....|..|:..|.|...:       .....|.|....
pombe   349 DSSSYKIVSK--------------NNHILLLYLNALDAPKQLLCYE-------ADPKNLYWDKDK 392

  Fly   430 FAAAYVLQIQKIEQPLNTSSKLLS------------------------NNIVQQGTP-------- 462
            |:...|||...: :|.|.|:..:|                        ||.::|...
pombe   393 FSDIPVLQHISM-KPSNASNHTVSLGYLNDRPNHSKKNSVTSTSSSQFNNFLEQNQKAVRSARHR 456

  Fly   463 --------------TSAETSGINISANRSGSALGLGVEATSTVLKLEK--ESLQLSGCQPETNVQ 511
                          ..::|||:|.||:.|....|   :|.....::||  .||.|
pombe   457 HYASLDEQGLHSLRNLSKTSGMNHSADFSLHEFG---QADPFAYEIEKPIASLPL---------- 508

  Fly   512 PSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLSTS---VASVHPQ----------------- 556
            |:.||.:...|:.|||.:.::.:.|.. ..:.|..|.|   ||.:..|
pombe   509 PNGNDTISRSSESSSPINESESNSLLK-LQSDFKFSNSDDRVAWLEEQLLYCMQQGYTLKPPNLF 572

  Fly   557 ---------------------------------------ISVISSTAAVTGNDTASPSGA----- 577
                                                   :|:.|..|.:.....|:...|
pombe   573 QHVDEKLRLEKKEQLSYLEILKVIEQMLESNEQKFKKQIVSLASENAKLAAQRDAAVENANYSRS 637

  Fly   578 ----------INSILQKFRPVVTAVRTSTTTAVSIATSTSDPLSVRVPSTMSANVVLSSSSSTLR 632
                      :.|:::|...:...|:.:...|.|.....:: |...:....||:.:|.|.:..|.
pombe   638 LIQKKTTDETVGSLIEKVGKLEYEVQGTLEEATSYYQKNTE-LQQLLKQNESASELLKSRNEKLC 701

  Fly   633 I----VPSVTASHSLRIASSQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTTSIGGKQYFIQ 693
            :    :.||....|.:|.|.|....|.:|    .||:.:...|..:|:     ..::....|.::
pombe   702 VDYDKLRSVFEEDSSKILSLQKENENLQS----QILQISEELVDYRSR-----CEALEYGNYELE 757

  Fly   694 -KPLTLAPNVQLQ---FVKTSGGMTVQTLPKVNFTAS-------KGT----------PPHGISIA 737
             |.:.:...|::|   ...::..:.|.....::|..|       |.|          ....:.|.
pombe   758 TKLIEMHDRVEMQTNVIEASASALDVSNTAILSFEDSLRRERDEKSTLQQKCLNLQYEYENVRIE 822

  Fly   738 NPHLASGITQIQGS---TVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKN-SNILQMGKVTPNV 798
            ..:|.|...:::.:   :|..::..|.|:...:.||:|.        |.:| .|:.:..|....:
pombe   823 LENLQSRALELESALEQSVSDAKYSKAIMQSGLSKLLSS--------INENKDNLKEFSKSKQKI 879

  Fly   799 MGGKPAFVITNKQGTP--LGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTP 861
                 :::.:..:|..  |...|.:   ..|..:.:..|.           ..:..:.:|.|:..
pombe   880 -----SYLESQLEGLHELLRESQRL---CEGRTKELLNSQ-----------QKLYDLKHSYSSVM 925

  Fly   862 SPLQALSGQKTLISNQSGVKMLRNISSVQ---ASSSMAFGQKQSG---TPIHQKTALYIGGKAVT 920
            :....||.|...::.|:.:.. |.:|.||   |.|.|  .|:.||   |.:|
pombe   926 TEKSKLSDQVNDLTEQAKITQ-RKLSEVQIALADSKM--NQQLSGKDSTDVH------------- 974

  Fly   921 VMSTNTSMAASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQS 985
             :.|:.|.::|..:.......|.||:.|   |.|:::|                      .||..
pombe   975 -LPTDFSASSSPLRSYFNEEDSFNNASA---AHSSKES----------------------DIPSG 1013

  Fly   986 QPVTETNNH--SVATIKDTDPMD--DIIEQLDGAGDLL----------------------KLSES 1024
            ...|:..||  ::.|.::|...|  |:.::|   .|::                      ||:::
pombe  1014 GVFTKYRNHFGNLMTSEETKAPDNNDLHKRL---SDVINSQQKFLSLSPQVSKDYYDVRSKLNDT 1075

  Fly  1025 EGQHGSEENENNGENATSSSASAL 1048
            .|....||.....:|..:|....|
pombe  1076 AGSFSGEEMRAIDDNYYASRIKQL 1099

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	10/44 (23%)
		KELCH repeat	74..115	CDD:276965	9/48 (19%)
		KELCH repeat	123..175	CDD:276965	12/58 (21%)
		Kelch_3	132..184	CDD:290151	17/58 (29%)
		Kelch_5	175..221	CDD:290565	18/45 (40%)
		KELCH repeat	178..239	CDD:276965	21/84 (25%)
		Kelch_3	260..305	CDD:290151	14/45 (31%)
		KELCH repeat	297..360	CDD:276965	13/62 (21%)
		Kelch_3	306..371	CDD:290151	10/64 (16%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
tea3	NP_594099.1	KELCH repeat	113..165	CDD:276965	12/57 (21%)
		Kelch_3	123..174	CDD:290151	16/56 (29%)
		Kelch_4	168..>202	CDD:290154	16/42 (38%)
		KELCH repeat	169..245	CDD:276965	21/84 (25%)
		Kelch_1	247..290	CDD:279660	13/48 (27%)
		KELCH repeat	248..290	CDD:276965	12/47 (26%)
		Kelch_4	297..342	CDD:290154	14/61 (23%)
		KELCH repeat	298..341	CDD:276965	13/59 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47199
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940