DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hcf and tea1

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	NP_588351.1	Gene:	tea1 / 2539047	PomBaseID:	SPCC1223.06	Length:	1147	Species:	Schizosaccharomyces pombe

Alignment Length:	1371	Identity:	263/1371 - (19%)
Similarity:	451/1371 - (32%)	Gaps:	449/1371 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 HSFANRISMDMDVPDGHQ-----LDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKE---LMVVF 89
            ||..:.:.|.......|:     ..|::|...|.::.........||:.|.:....|   .:.:|
pombe    34 HSHESNVKMSTSTVTEHRKKPTGSGSHITASPWSKLTVRGSSNVLPRYSHASHLYAEGGQEIYIF 98

  Fly    90 GG--GNEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEY---GKYSN 149
            ||  .:....::|.|.|..|:|:......|:.|:....:..::.|....||||:..:   .:..|
pombe    99 GGVASDSQPKNDLWVLNLATSQFTSLRSLGETPSPRLGHASILIGNAFIVFGGLTNHDVADRQDN 163

  Fly   150 ELYELQATKWEWRKMYPESPDSGLSPCPRLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDL 214
            .||.|..:...|:|    :..||..|..|.||:.:.:|.||.||||         ..:..|.|||
pombe   164 SLYLLNTSSLVWQK----ANASGARPSGRYGHTISCLGSKICLFGG---------RLLDYYFNDL 215

  Fly   215 YILDTRGVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCR-LGDLWLLE 278
            ...|...:::.:.:|.:.....|.||.|..|...:|:.|      |.|:||..|.. ..|||...
pombe   216 VCFDLNNLNTSDSRWELASVVNDPPPARAGHVAFTFSDK------LYIFGGTDGANFFNDLWCYH 274

  Fly   279 TDSMTWSKPKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLE 343
            .....|||.:|.|.||.||:.|:::::...:|||||
pombe   275 PKQSAWSKVETFGVAPNPRAGHAASVVEGILYVFGG----------------------------- 310

  Fly   344 TMTWENVTLDTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYA 408
                             ||..|                                   .....|||
pombe   311 -----------------RASDG-----------------------------------TFLNDLYA 323

  Fly   409 VKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAET---SGI 470
            .::    :|.|..:||                 :.|...|             |.|:.|   ||:
pombe   324 FRL----SSKHWYKLS-----------------DLPFTPS-------------PRSSHTLSCSGL 354

  Fly   471 NISANRSGSALGLGVEATSTVLKLEKESLQL------SGCQPET--------NVQPSV-NDLLQS 520
            .:..  .|...|.|. :.|.|..|:....:|      ||.|..|        |..||. |.||.|
pombe   355 TLVL--IGGKQGKGA-SDSNVYMLDTSRFRLGSVPTTSGRQRNTSFFSNSTGNTNPSAFNGLLTS 416

  Fly   521 MSQPSSPASRA------DKDPLSSGGGTTFNLSTSVASVHPQISV-ISSTAAVTGNDTASPSGAI 578
            ...||...|:.      .:........:.||      :.|..||. :|..|:   ||..||
pombe   417 SRIPSYNGSKVRSTSHPSRQQYIGSSNSRFN------TRHQTISTPVSGRAS---NDLPSP---- 468

  Fly   579 NSILQKFRPVVTAVRTSTTT----AVSIATSTSDPLSVRVPSTMSANVVLSSS--------SSTL 631
                      |...|:::::    :.::.:.:||..:.......|.|....|:        |.||
pombe   469 ----------VVPTRSNSSSILQPSYNLNSHSSDRRNTNDDDQSSLNSQQLSNQAKAQGEVSPTL 523

  Fly   632 RIVPSVTASHSLRIAS-SQASGNNCRSSSAINILKTALPNVAVQSQPTSSTTT-----SIGGK-- 688
            ..|||   |||:...: |.||.||.:|.:|...:.:......|:....||..|     |:.|:
pombe   524 SFVPS---SHSMEQGNGSVASANNAQSEAATRSINSISEVSEVRFPEQSSVKTVDERKSLDGRIT 585

  Fly   689 ----QYFIQKPLTLAPNVQLQFVKTS-GGMTVQTLPKVNFTASKGTPPHGISIANPHLASGITQI 748
                :..::|...|:....:::.|:. ..:...:..|::....|      :.:||....:.:.:.
pombe   586 SVTLETLVEKYSELSKQQIVEWFKSKLYEILRDSASKIDSLTEK------LKVANAEKNAALCEA 644

  Fly   749 QGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNVMGGKPAFVITNKQGT 813
            ....||                            :...|.|..|           .|...:|:
pombe   645 ALEKVP----------------------------LAKHNKLSDG-----------TFSTPDKE-- 668

  Fly   814 PLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTST---------TPSP----LQ 865
                          ||:|...:.:|..   :.|....:.::..||:         |.|.    :|
pombe   669 --------------NVQSTNDAHIMQE---NFSLHKALEVMRETSSDLDKQLKDATASQKELIVQ 716

  Fly   866 ALSGQKTLISNQSG----VKMLRNISSVQASSSM------------------------AFGQKQS 902
            ..|.||.|:..:..    .|.|:.|.|:.....:                        .|.::..
pombe   717 TSSFQKELVEERERHNAISKRLQEIESLYRDRELLVTNLEDQLVDQTVTINKFAFERDQFRERSM 781

  Fly   903 GTPIHQKTALYIGGKAVTVMSTNTSMAASGNKVMVLPGTSSNNSPATTTAL----SARKSFVFNA 963
            |   .:.|...:..|.......|.|:..|...|.     :.|:...|..||    ..:|..:.:|
pombe   782 G---FENTIKDLTRKMEATDMLNVSLHESLRSVQ-----TENSELVTEMALLKAELVKKQAIIDA 838

  Fly   964 GGSPRTVTLATKSINAKSIPQSQPVTETNNHSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQH 1028
                          || :|........||..:|:...:.:..:.:.:.|:|:.| .|.:|.|..|
pombe   839 --------------NA-NIYDKLTADHTNYETVSADINQNLKETLDKLLNGSSD-FKNNEIELLH 887

  Fly  1029 GSEENENNGENATSSSASALFTGGDTAGPSRAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSG 1093
                ::....||.......|....                  ..|||    :..:::.|.|
pombe   888 ----DQIRITNAKLEKREKLINAS------------------KYIED----TLRSEIQEAA---- 922

  Fly  1094 DTIESLKMS----EKENDDV----------KSMGEKSILSDDCHQPTTSETEAATILTTIKSAEA 1144
            :.:.:|:.|    ::||.::          ::.|.|.:::... |.:|:.:|...:...:::. |
pombe   923 EKVSNLEFSNFNLKEENSNMQLQLMKALEQRNTGAKQLVNLRM-QLSTATSELDMLKLKLRTT-A 985

  Fly  1145 LVLETAE---------IRKD-------HTGC-----TIGSLKEN---------------QDENKK 1173
            |.||.:.         :|.|       |..|     |:..:|..               ::.:.|
pombe   986 LALEESPDDYSDILSILRADMSPFHDLHKQCGVLIDTLNGVKRGFGIFEKKFTDYHKFLENISDK 1050

  Fly  1174 FKQRQESSPSQNIHQFQNVDGSQLEALASAALLQAATSDTTALALKELIE------RPESETNTR 1232
            .|..:::|....||:.|::...|::.:........:.||:..| ||..|:      .|.|.::..
pombe  1051 LKSEEDTSLETPIHENQSIQSDQIKEVGEVLSAIKSLSDSVML-LKNQIDDLAKEKLPLSSSDDE 1114

  Fly  1233 SSNIAE 1238
            ..||.|
pombe  1115 KVNIKE 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	11/41 (27%)
		KELCH repeat	74..115	CDD:276965	11/45 (24%)
		KELCH repeat	123..175	CDD:276965	13/54 (24%)
		Kelch_3	132..184	CDD:290151	17/54 (31%)
		Kelch_5	175..221	CDD:290565	16/45 (36%)
		KELCH repeat	178..239	CDD:276965	17/60 (28%)
		Kelch_3	260..305	CDD:290151	18/45 (40%)
		KELCH repeat	297..360	CDD:276965	7/62 (11%)
		Kelch_3	306..371	CDD:290151	8/64 (13%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
tea1	NP_588351.1	KELCH repeat	80..131	CDD:276965	12/50 (24%)
		Kelch_3	92..142	CDD:290151	10/49 (20%)
		KELCH repeat	134..181	CDD:276965	11/50 (22%)
		Kelch_3	143..194	CDD:290151	17/54 (31%)
		Kelch_2	187..236	CDD:284956	16/57 (28%)
		KELCH repeat	188..239	CDD:276965	16/59 (27%)
		Kelch_1	242..287	CDD:279660	16/50 (32%)
		KELCH repeat	243..290	CDD:276965	17/52 (33%)
		Kelch_4	292..338	CDD:290154	18/147 (12%)
		KELCH repeat	293..338	CDD:276965	17/146 (12%)
		SbcC	594..>1121	CDD:223496	104/648 (16%)
		ATP-synt_B	<608..726	CDD:304375	26/181 (14%)
		RILP-like	<866..952	CDD:304877	19/116 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47199
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940