DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hcf and Rabepk

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_663497.2 Gene:Rabepk / 227746 MGIID:2139530 Length:380 Species:Mus musculus


Alignment Length:334 Identity:78/334 - (23%)
Similarity:134/334 - (40%) Gaps:74/334 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKEL-------MVVFGGGNEG-IVDELHVYNTVTNQWYVPVLK 116
            |..:..| |.:|.||.||.......:       :.:.||.|.. ...::|..:..|:||.....:
Mouse    26 WYTLTCP-GDRPCPRVGHSCSYFPPVGDAESGKIFIVGGANPNQSFSDVHTMDLGTHQWDTATRE 89

  Fly   117 GDVPN--------GCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPD-SG 172
            |.:|.        .|:.:.       ::||||..:.|. .|.|..:......|     .:|: :|
Mouse    90 GLLPRYEHASFLPSCSPHS-------IWVFGGADQSGN-RNCLQVMSPEDRTW-----STPEVTG 141

  Fly   173 LSPCPRLGH-SFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYG 236
            ..|.||..| |...:|.::::||| ......|..::     .|::.|...:     .|..|:|:|
Mouse   142 SPPSPRTFHTSSAAIGNQLYVFGG-GERGAQPVEDV-----KLHVFDANTL-----TWSQPETHG 195

  Fly   237 DSPPPRESHTGISFATKSNGNLNLLIYGGMSGCR-LGDLWLLETDSMTWSKPKTSGEAPLPRSLH 300
            ..|.||..|..::..||      |.|:||::|.: ..||..::...|:|.|...:|..|:..:.|
Mouse   196 SPPSPRHGHVMVAAGTK------LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAH 254

  Fly   301 SSTMIGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVL---DLETMTWENVTLDTVEENVPRA 362
            ::..:|:.:|:|||..                .|..|.::   ..|...|..:..||   ::|..
Mouse   255 AAVAVGHHVYMFGGMT----------------ATGALNMMYKYHTEKQHWTVLQFDT---SLPAG 300

  Fly   363 RAGH--CAV 369
            |..|  |.:
Mouse   301 RLDHSMCVI 309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 9/44 (20%)
KELCH repeat 74..115 CDD:276965 10/48 (21%)
KELCH repeat 123..175 CDD:276965 11/52 (21%)
Kelch_3 132..184 CDD:290151 15/53 (28%)
Kelch_5 175..221 CDD:290565 12/46 (26%)
KELCH repeat 178..239 CDD:276965 14/61 (23%)
Kelch_3 260..305 CDD:290151 13/45 (29%)
KELCH repeat 297..360 CDD:276965 12/65 (18%)
Kelch_3 306..371 CDD:290151 15/69 (22%)
FN3 <1307..1338 CDD:238020
FN3 1344..1448 CDD:238020
RabepkNP_663497.2 Kelch_2 38..90 CDD:369447 11/51 (22%)
Kelch 1 57..103 9/45 (20%)
KELCH repeat 94..143 CDD:276965 11/61 (18%)
Kelch_3 107..155 CDD:379174 15/60 (25%)
Kelch 2 108..154 15/58 (26%)
PLN02193 <134..>302 CDD:177844 50/208 (24%)
KELCH repeat 147..198 CDD:276965 14/61 (23%)
Kelch 3 159..211 14/62 (23%)
KELCH repeat 201..243 CDD:276965 14/47 (30%)
Kelch 4 212..258 14/51 (27%)
KELCH repeat 251..291 CDD:276965 10/55 (18%)
Kelch 5 262..311 14/67 (21%)
Kelch 6 357..380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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