DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and hcf-1

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_501279.1 Gene:hcf-1 / 177560 WormBaseID:WBGene00001827 Length:782 Species:Caenorhabditis elegans


Alignment Length:1471 Identity:367/1471 - (24%)
Similarity:497/1471 - (33%) Gaps:746/1471 - (50%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 IQAENHSFANRISMDMDVPDGHQLDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGG 92
            ::|.|:|..       |.....:.:.|:.  ||:.|...|||.|:|||||||:.:|||:|:||||
 Worm     7 LEATNYSRG-------DESRSEEQEKNVV--RWRIVQQSTGPNPKPRHGHRAVVLKELIVIFGGG 62

  Fly    93 NEGIVDELHVYNTVTNQWYVPVLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQAT 157
            |||::||||.|||...:|..|...||||...||:|.:..|.:::.||||.|||||:|:|||||:|
 Worm    63 NEGMIDELHAYNTQKREWTAPQCCGDVPTPAAAFGAISLGNKIYRFGGMTEYGKYTNDLYELQST 127

  Fly   158 KWEWRKMYPESPDSGLSPCPRLGHSF--TMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTR 220
            :||||::.|....:|..||||:||||  :...:|.::||||:|:.:|||.|:|.||:|||:::..
 Worm   128 RWEWRRLNPRVHSNGHLPCPRIGHSFVVSQKSQKAYVFGGLSNDLNDPKRNVPHYLDDLYVINLS 192

  Fly   221 GVHSHNGKWIVPKTYGDSPPPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWS 285
            |  ..:..|......|..|..|||||.:.:...|..  .:::||||:|.||||||.|..:::.|:
 Worm   193 G--PQHLIWEKLNATGPGPISRESHTAVIYEKDSIS--RMVVYGGMNGVRLGDLWYLNLNTLHWT 253

  Fly   286 K-----PKTSGEAPLPRSLHSSTMIGNKMYVFGGWVPLVINDS-KSTTEREWKCTNTLAVLDLET 344
            :     |:| |..|:|||||||.:||:||:|:||||||:.:.| :..||:|||||::|...::..
 Worm   254 EIKFDDPRT-GIPPMPRSLHSSVLIGDKMFVYGGWVPLLEHASTEQQTEKEWKCTSSLGCWNITE 317

  Fly   345 MTWENVTL-DTVEENVPRARAGHCAVGIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYA 408
            ..|..:.| .:.|:.:||.||||||..:..|:|:|||||||||||:|||||:|:|.|:...|...
 Worm   318 DRWVPLHLYCSDEDTIPRGRAGHCAAAVGDRMYIWSGRDGYRKAWSNQVCCRDMWLLDTILPEQP 382

  Fly   409 VKVALVRASTHALELSWTATTFAAAYVLQIQKIEQPLNTSSKLLSNNIVQQGTPTSAETSGINIS 473
            .||.|.||..::||:||.....|:.|.|||                                   
 Worm   383 GKVQLGRAGFNSLEISWPIVQGASGYFLQI----------------------------------- 412

  Fly   474 ANRSGSALGLGVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSS 538
                    |.|                                  .:..|..||..||       
 Worm   413 --------GFG----------------------------------DAKEQSVSPIKRA------- 428

  Fly   539 GGGTTFNLSTSVASVHPQISVISSTAAVTGNDTASPSGAINSILQKFRPVVTAVRTSTTTAVSIA 603
                                            |.||                             
 Worm   429 --------------------------------TTSP----------------------------- 432

  Fly   604 TSTSDPLSVRVPSTMSANVVLSSSSSTLRIVPSVTASHSLRIASSQASGNNCRSSSAINILKTAL 668
                                        |..||:.                              
 Worm   433 ----------------------------RKQPSIV------------------------------ 439

  Fly   669 PNVAVQSQPTSSTTTSIGGKQYFIQKPLTLAPNVQLQFVKTSGGMTVQTLPKVNFTASKGTPPHG 733
                    |.|...|....|     ||...||::    :.|.|  |..|.|              
 Worm   440 --------PPSQKETEQSPK-----KPQGTAPSI----ISTQG--TTYTAP-------------- 471

  Fly   734 ISIANPHLASGITQIQGSTVPGSQIQKPIVSGNVLKLVSPHTMAGGKLIMKNSNILQMGKVTPNV 798
               |:|                                                           
 Worm   472 ---ADP----------------------------------------------------------- 474

  Fly   799 MGGKPAFVITNKQGTPLGNQQIIIVTTGGNVRSVPTSTVMTSAGGSASGTNIVSIVNSTSTTPSP 863
               |||                                  |..||                    
 Worm   475 ---KPA----------------------------------TDEGG-------------------- 482

  Fly   864 LQALSGQKTLISNQSGVKMLRNISSVQASSSMAFGQKQSGTPIHQKTALYIGGKAVTVMSTNTSM 928
                                                                             
 Worm   483 ----------------------------------------------------------------- 482

  Fly   929 AASGNKVMVLPGTSSNNSPATTTALSARKSFVFNAGGSPRTVTLATKSINAKSIPQSQPVTETNN 993
                                                                 :||         
 Worm   483 -----------------------------------------------------LPQ--------- 485

  Fly   994 HSVATIKDTDPMDDIIEQLDGAGDLLKLSESEGQHGSEENENNGENATSSSASALFTGGDTAGPS 1058
                                                                             
 Worm   486 ----------------------------------------------------------------- 485

  Fly  1059 RAQNPIVMEHPVDIIEDVSGVSSTTDVNETAIVSGDTIESLKMSEKENDDVKSMGEKSILSDDCH 1123
                        |:.||       |:.||||            |.|.::|.:|..     |..|.
 Worm   486 ------------DLFED-------TEKNETA------------SPKRSNDAQSAD-----SSTCE 514

  Fly  1124 QPTTSETEAATILTTIKSAEALVLETAEIRKDHTGCTIGSLKENQDENKKFKQRQESSPSQNIHQ 1188
            |..|.|:                                .|:|:.::::|        ||.    
 Worm   515 QKKTDES--------------------------------GLEEDSEKDQK--------PSD---- 535

  Fly  1189 FQNVDGSQLEALASAALLQAATSDTTALALKELIERPESETNTRSSNIAEIQQNNVQSTLAVVVP 1253
                                                 ..||:       |:::.|          
 Worm   536 -------------------------------------AGETD-------EMKEEN---------- 546

  Fly  1254 NTSQNENQKWHTVGVFKDLSHTVTSY---------------IDSN---CISDSFFDGIDVDNLPD 1300
               .:::..|..||:....:..||.|               ||.|   |::||.|...|      
 Worm   547 ---GDDDLPWFDVGIIDKATINVTHYFNDRQQSLEKQLNDLIDHNAFKCVNDSVFTTED------ 602

  Fly  1301 FSKFPRTNLEPGTAYRFRLSAINSCGRGEWGEISSFKTCLPGFPGAPSAIKISKDVKEGAHLTWE 1365
              |.|..|   |.:||||:||||..|:|.|.|.:|.|||:||:|.|||:|:|:|. .|||.||||
 Worm   603 --KIPLIN---GQSYRFRVSAINGLGKGAWSETASCKTCVPGYPSAPSSIRITKS-HEGAQLTWE 661

  Fly  1366 PPP-AQKTKEIIEYSVYLAVKPTAKDKALSTPQLAFVRVYVGAANQCTVPNASLSNAHVDCSNKP 1429
            ||. ...:.:|||||||||||..:.:.|.|  ||||:|||.|....|.|..::|..|.||.:|||
 Worm   662 PPSNTNISGKIIEYSVYLAVKNQSANSADS--QLAFMRVYCGPQADCQVLQSNLGTAFVDQTNKP 724

  Fly  1430 AIIFRIAARNQKGYGPATQVRWLQDPAAAKQHTPTVT--PN 1468
            ||||||||||:||||||||||||||    :|..|..|  ||
 Worm   725 AIIFRIAARNEKGYGPATQVRWLQD----QQKIPVRTNYPN 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 25/36 (69%)
KELCH repeat 74..115 CDD:276965 26/40 (65%)
KELCH repeat 123..175 CDD:276965 26/51 (51%)
Kelch_3 132..184 CDD:290151 31/53 (58%)
Kelch_5 175..221 CDD:290565 24/47 (51%)
KELCH repeat 178..239 CDD:276965 24/62 (39%)
Kelch_3 260..305 CDD:290151 24/49 (49%)
KELCH repeat 297..360 CDD:276965 29/64 (45%)
Kelch_3 306..371 CDD:290151 30/66 (45%)
FN3 <1307..1338 CDD:238020 15/30 (50%)
FN3 1344..1448 CDD:238020 62/104 (60%)
hcf-1NP_501279.1 Kelch_1 43..81 CDD:279660 25/37 (68%)
KELCH repeat 44..89 CDD:276965 27/44 (61%)
KELCH repeat 93..145 CDD:276965 26/51 (51%)
Kelch_3 102..155 CDD:290151 31/52 (60%)
Kelch_5 145..193 CDD:290565 24/47 (51%)
KELCH repeat 212..267 CDD:276965 22/57 (39%)
Kelch_3 227..277 CDD:290151 24/50 (48%)
KELCH repeat 269..334 CDD:276965 29/64 (45%)
Kelch_5 334..376 CDD:290565 29/41 (71%)
PPP4R2 <488..546 CDD:286293 24/169 (14%)
FN3 <606..635 CDD:238020 15/31 (48%)
FN3 641..739 CDD:214495 58/100 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166919
Domainoid 1 1.000 153 1.000 Domainoid score I2634
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 576 1.000 Inparanoid score I557
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D202078at33208
OrthoFinder 1 1.000 - - FOG0002961
OrthoInspector 1 1.000 - - oto20636
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR46003
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1494
SonicParanoid 1 1.000 - - X2316
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1111.030

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