Protein Alignment Hcf and Fbxo42

DIOPT Version :10

• Sequence 1: NP_524621.2
• Gene: Hcf / 43788
• FlyBaseID: FBgn0039904
• Length: 1500
• Species: Drosophila melanogaster
• Sequence 2: XP_320189.5
• Gene: Fbxo42 / 1280344
• VectorBaseID: AGAMI1_002333
• Length: 632
• Species: Anopheles gambiae
• Alignment Length: 639
• Identity: 122/639 - (19%)
• Similarity: 204/639 - (31%)
• Gaps: 244/639 - (38%)

  Fly    51 LDSNLTGFRWKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGN--EGIVDELHVYNTVTNQWYVP 113
            :|.||.   ||.:|..:.|:...|..|.:...:..|.||||.:  :...::|..::....:|..|
Mosquito    56 IDFNLC---WKEILQESTPRIAARFAHASSLHRNSMYVFGGASSCDTTFNDLWRFDLSRREWIRP 117

  Fly   114 VLKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLSPCPR 178
            :..|..|:..|....|.....:.:|||                    |:..|        :|.
Mosquito   118 ISMGTYPSPKAGASLVCHNDLLILFGG--------------------WQHAY--------TPF-- 152

  Fly   179 LGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHN---GKWIV-PKTYGDSP 239
              |..|::.|                                 :|.:|   .:|.: .:.||  |
Mosquito   153 --HMCTLIDE---------------------------------LHVYNIAENRWTIHNQAYG--P 180

  Fly   240 PPRESHTGISFATKSNGNLNLLIYGGMSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSSTM 304
            ||                        |:|                               ||:::
Mosquito   181 PP------------------------MTG-------------------------------HSASV 190

  Fly   305 IGNKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVPRARAGHCAV 369
            ..|||.:|||:...:.|         .:.:|.:.|||||.:.|:...:..::. .||......|:
Mosquito   191 HRNKMILFGGYQKNMEN---------LRTSNDIWVLDLERLVWKKPAVSDLKP-APRYGQFQMAI 245

  Fly   370 GIQSRLYVWSGRDGYRKAWNNQVCCKDLWYLEVSKPLYAVKVALVRASTHALELSWTATTFAAAY 434
            | :..:.|..|..|..:.:|      |.|.|::.:..:..|...::.....:..:|   .:.|.
Mosquito   246 G-EDHILVLGGTGGVNRVFN------DAWLLDMQRDTWVWKRVQIKNKKSIVTHNW---CYPAC- 299

  Fly   435 VLQIQKIEQPLNTSSKLL--------------SNNIVQQG--TPTSAETSGINISANRSGSALGL 483
                       |..||::              .|.:...|  .||:.:.      .||.|:|...
Mosquito   300 -----------NVGSKVIVLGPTSPNDFQIIRPNRVPPMGRTRPTAEQL------RNRIGAAPHG 347

  Fly   484 GVEATSTVLKLEKESLQLSGCQPETNVQPSVNDLLQSMSQPSSPASRADKDPLSSGGGTTFNLST 548
            .::|                  .|.|:.|..|      ..|..||......|..|.|
Mosquito   348 PMQA------------------GEPNIPPRAN------LPPPPPAPMQPTLPGPSQG-------- 380

  Fly   549 SVASVHPQISVISSTAAVTGNDTASPSGAINS--ILQKFRPVVTAVRTSTTTAVSIATSTSDPLS 611
                |.|:.|..||     |...:.|...:||  .:.:.||..:.:||.::||       ..|.|
Mosquito   381 ----VSPKESNPSS-----GPGPSKPPSTVNSGVPVVEARPGPSGLRTPSSTA-------PGPPS 429

  Fly   612 VRVPSTMSANVVLSSSSSTLRIVP------SVTASHSLRIASSQASGNNCRSSS 659
            ..:|...||   .|..||....:|      ::..:|...:|.|..|.|:..::|
Mosquito   430 RSMPIIRSA---FSRQSSEDDHLPKRFNQQNLEHNHMAMVAFSVDSSNHASNAS 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	PLN02193	<59..363	CDD:177844	55/309 (18%)
		KELCH repeat	74..115	CDD:276965	10/42 (24%)
		KELCH repeat	123..175	CDD:276965	7/51 (14%)
		KELCH repeat	178..239	CDD:276965	8/64 (13%)
		KELCH repeat	297..360	CDD:276965	16/62 (26%)
		FN3	<1307..>1381	CDD:442628
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
Fbxo42	XP_320189.5	None