DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and KLHDC1

DIOPT Version :9

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_751943.1 Gene:KLHDC1 / 122773 HGNCID:19836 Length:406 Species:Homo sapiens


Alignment Length:343 Identity:93/343 - (27%)
Similarity:155/343 - (45%) Gaps:74/343 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    74 RHGHRAINIKELMVVFGG-----GNEGIV--DELHVYNTVTNQWYVPVLKGDVPNGCA-AYGFVV 130
            |.||.|:.....:.|:||     .||..:  ||:..|:..:..|.:.:::|::|...: :.|..:
Human    13 RSGHCAVVDGNFLYVWGGYVSIEDNEVYLPNDEIWTYDIDSGLWRMHLMEGELPASMSGSCGACI 77

  Fly   131 EGTRMFVFGGMIEYGKYSNELYELQ-ATKWE---WRKMYPESPDSGLSPCPRLGHSFTMVGEKIF 191
            .| ::::|||..:.| |||.||.:. .|:.|   |.|:   :...|..|.||...|..:..:::.
Human    78 NG-KLYIFGGYDDKG-YSNRLYFVNLRTRDETYIWEKI---TDFEGQPPTPRDKLSCWVYKDRLI 137

  Fly   192 LFGGLA----NESDD---------PKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPP-PR 242
            .|||..    :|..|         .:.....:.||::|.||:     ...|..|:..|..|| ||
Human   138 YFGGYGCRRHSELQDCFDVHDASWEEQIFWGWHNDVHIFDTK-----TQTWFQPEIKGGVPPQPR 197

  Fly   243 ESHTGISFATKSNGNLNLLIYGG-MSGCRLGDLWLLETDSMTWSKPKT-SGEAPLPRSLHSSTMI 305
            .:||......|.      .|:|| :...|:.||..|..|:.|||...| :||:|..||.|:.|.|
Human   198 AAHTCAVLGNKG------YIFGGRVLQTRMNDLHYLNLDTWTWSGRITINGESPKHRSWHTLTPI 256

  Fly   306 G-NKMYVFGGW----VPLVINDSKSTTEREWKCTNTLAVLDLETMTWENVTLDTVEENVP--RAR 363
            . :|:::.||.    :||  :|.       |       :.::.|..|:.:|      ::|  |.|
Human   257 ADDKLFLCGGLSADNIPL--SDG-------W-------IHNVTTNCWKQLT------HLPKTRPR 299

  Fly   364 AGHCA-VGIQSRLYVWSG 380
            ..|.| :|.::.:.|:.|
Human   300 LWHTACLGKENEIMVFGG 317

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 Kelch_1 73..110 CDD:279660 12/42 (29%)
KELCH repeat 74..115 CDD:276965 13/47 (28%)
KELCH repeat 123..175 CDD:276965 16/56 (29%)
Kelch_3 132..184 CDD:290151 19/55 (35%)
Kelch_5 175..221 CDD:290565 14/58 (24%)
KELCH repeat 178..239 CDD:276965 15/73 (21%)
Kelch_3 260..305 CDD:290151 19/46 (41%)
KELCH repeat 297..360 CDD:276965 15/67 (22%)
Kelch_3 306..371 CDD:290151 15/72 (21%)
FN3 <1307..1338 CDD:238020
FN3 1344..1448 CDD:238020
KLHDC1NP_751943.1 KELCH repeat 13..65 CDD:276965 14/51 (27%)
Kelch_5 13..54 CDD:290565 12/40 (30%)
Kelch 1 24..76 12/51 (24%)
KELCH repeat 69..194 CDD:276965 33/134 (25%)
Kelch_3 78..124 CDD:290151 16/50 (32%)
Kelch 2 80..134 18/57 (32%)
Kelch 3 135..181 10/50 (20%)
Kelch_3 <170..205 CDD:290151 14/39 (36%)
KELCH repeat 197..235 CDD:276965 13/43 (30%)
Kelch_3 206..256 CDD:290151 20/55 (36%)
Kelch 4 208..258 21/55 (38%)
Kelch_4 247..294 CDD:290154 15/68 (22%)
KELCH repeat 248..294 CDD:276965 15/67 (22%)
Kelch 5 260..307 15/68 (22%)
Kelch 6 311..361 2/7 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165145645
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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