DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hcf and KLHDC3

DIOPT Version :9

Sequence 1:	NP_524621.2	Gene:	Hcf / 43788	FlyBaseID:	FBgn0039904	Length:	1500	Species:	Drosophila melanogaster
Sequence 2:	XP_024302088.1	Gene:	KLHDC3 / 116138	HGNCID:	20704	Length:	395	Species:	Homo sapiens

Alignment Length:	280	Identity:	81/280 - (28%)
Similarity:	129/280 - (46%)	Gaps:	44/280 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 RW------KRVLNPTGP-QPRPRHGHRAINIKELMVVFGGGN--EGIVDELHVYNTVTNQWYVPV 114
            ||      |..:....| .|..|:||..:.|.:.::::||.|  ||..:.|:.::..|::|:.|.
Human    68 RWTKLPPVKSAIRGQAPVVPYMRYGHSTVLIDDTVLLWGGRNDTEGACNVLYAFDVNTHKWFTPR 132

  Fly   115 LKGDVPNGCAAYGFVVEGTRMFVFGGMIEYGK-YSNELYELQATKWEWRKMYPESPDSGLSPCP- 177
            :.|.||.....:...|.|..|::|||..:... :||::::|..:...|..:..:.     ||..
Human   133 VSGTVPGARDGHSACVLGKIMYIFGGYEQQADCFSNDIHKLDTSTMTWTLICTKG-----SPARW 192

  Fly   178 RLGHSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDSPPP- 241
            |..||.||:|..:::|||.|:......:|...|.|.:.:.|||     ...|:      |.||.
Human   193 RDFHSATMLGSHMYVFGGRADRFGPFHSNNEIYCNRIRVFDTR-----TEAWL------DCPPTP 246

  Fly   242 -----RESHTGISFATKSNGNLNLLIYGGMSGCRLG----DLWLLETDSMTWSKPKTSGEAPLPR 297
                 |.||:...:    ||  .|.|:||.: .||.    |||.....|.||.|.:..|:.|.||
Human   247 VLPEGRRSHSAFGY----NG--ELYIFGGYN-ARLNRHFHDLWKFNPVSFTWKKIEPKGKGPCPR 304

  Fly   298 SLHSSTMIGNKMYVFGGWVP 317
            ......::|:|:.:|||..|
Human   305 RRQCCCIVGDKIVLFGGTSP 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hcf	NP_524621.2	Kelch_1	73..110	CDD:279660	11/38 (29%)
		KELCH repeat	74..115	CDD:276965	13/42 (31%)
		KELCH repeat	123..175	CDD:276965	10/52 (19%)
		Kelch_3	132..184	CDD:290151	14/53 (26%)
		Kelch_5	175..221	CDD:290565	16/46 (35%)
		KELCH repeat	178..239	CDD:276965	18/60 (30%)
		Kelch_3	260..305	CDD:290151	17/48 (35%)
		KELCH repeat	297..360	CDD:276965	7/21 (33%)
		Kelch_3	306..371	CDD:290151	6/12 (50%)
		FN3	<1307..1338	CDD:238020
		FN3	1344..1448	CDD:238020
KLHDC3	XP_024302088.1	PLN02193	63..>331	CDD:330882	81/280 (29%)
		KELCH repeat	90..135	CDD:276965	13/44 (30%)
		KELCH repeat	141..186	CDD:276965	10/44 (23%)
		KELCH repeat	193..249	CDD:276965	20/66 (30%)
		KELCH repeat	252..296	CDD:276965	18/50 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940