DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hcf and zgc:163014

DIOPT Version :10

Sequence 1:NP_524621.2 Gene:Hcf / 43788 FlyBaseID:FBgn0039904 Length:1500 Species:Drosophila melanogaster
Sequence 2:NP_001083015.2 Gene:zgc:163014 / 100038766 ZFINID:ZDB-GENE-070424-100 Length:578 Species:Danio rerio


Alignment Length:445 Identity:97/445 - (21%)
Similarity:167/445 - (37%) Gaps:134/445 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 EGSDFVDPAFSSGE------RISASDLNSEHIIQAENHSFANRI-SMDMDVPDGHQLDSNLTGFR 59
            |...|.||...|..      ::||.||..|..::        |: |...|.|..          |
Zfish   210 ELESFKDPIPGSSPKKRKLCKMSAVDLEDETAVK--------RVKSFRADCPSK----------R 256

  Fly    60 WKRVLNPTGPQPRPRHGHRAINIKELMVVFGGGNEGIVDELHVYNT-----VTNQWYVPVLKGDV 119
            |...:..:.|              |..::.||..:   |:....::     :.|.::.|:   ||
Zfish   257 WSHAMCLSDP--------------ETAILIGGEAD---DQATCKDSIWKLEIENDFWFPM---DV 301

  Fly   120 -------PNG---CAAYGFVVEGTRMFVFGGMIEYGKYSNELYELQATKWEWRKMYPESPDSGLS 174
                   ||.   .|.|.  .|...::|:||..|..:|| :::.|..|.|:|:.:      |...
Zfish   302 SSSEFCPPNSQGHSATYD--PESKVVYVYGGFREGQRYS-DIHVLDTTTWKWKLI------SAKG 357

  Fly   175 PCPRLG-HSFTMVGEKIFLFGGLANESDDPKNNIPKYLNDLYILDTRGVHSHNGKWIVPKTYGDS 238
            ..|.|. ||.|:..:::::|||| ..|..|:..:..  |.|||.     :..:|.|..|...||.
Zfish   358 KIPSLAYHSATVYKKELYVFGGL-QPSRCPEGRVCS--NALYIF-----NPEHGLWYQPIVEGDR 414

  Fly   239 PPPRESHTGISFATKSNGNLNLLIYGG-MSGCRLGDLWLLETDSMTWSKPKTSGEAPLPRSLHSS 302
            |.||..|:....:.|      ::|:|| .:...|.||.:|:...|.::..|.....||.|..|::
Zfish   415 PLPRFGHSTTLLSNK------MVIFGGRKTATYLNDLHILDLGFMEYTAVKHENMPPLARGFHAA 473

  Fly   303 TMIG-NKMYVFGGWVPLVINDSKSTTEREWKCTNTLAVLDL-----ETMTWENVTLDTVEENVPR 361
            ..:. |::.:.||                  |:...|:.||     ::.:|.::...::   ..:
Zfish   474 LPVSDNRVLISGG------------------CSAVGALQDLHLFNIDSSSWTSLVSPSL---CCK 517

  Fly   362 ARAGHCAV----------------------GIQSRLYVWSGRDGYRKAWNNQVCC 394
            .||||..:                      .:|..:.::.|.|.....:|:.|.|
Zfish   518 PRAGHSLISLGFTKPSELRDARDRRHANSPSLQCAILMFGGSDCSGTFYNDTVKC 572

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HcfNP_524621.2 PLN02193 <59..363 CDD:177844 73/326 (22%)
KELCH repeat 74..115 CDD:276965 6/45 (13%)
KELCH repeat 123..175 CDD:276965 14/51 (27%)
KELCH repeat 178..239 CDD:276965 19/61 (31%)
KELCH repeat 297..360 CDD:276965 10/68 (15%)
FN3 <1307..>1381 CDD:442628
FN3 <1307..1338 CDD:238020
FN3 1344..1448 CDD:238020
zgc:163014NP_001083015.2 KELCH repeat 256..311 CDD:276965 12/74 (16%)
Kelch_4 256..296 CDD:433191 8/56 (14%)
NanM 325..>528 CDD:442289 61/244 (25%)
KELCH repeat 363..414 CDD:276965 17/58 (29%)
KELCH repeat 418..464 CDD:276965 12/51 (24%)
KELCH repeat 468..509 CDD:276965 10/58 (17%)
Blue background indicates that the domain is not in the aligned region.

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