DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and PMA2

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_015289.1	Gene:	PMA2 / 856071	SGDID:	S000005957	Length:	947	Species:	Saccharomyces cerevisiae

Alignment Length:	1105	Identity:	232/1105 - (20%)
Similarity:	420/1105 - (38%)	Gaps:	338/1105 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IDGRPAQYGISLKQLRELMEHRGREGVMKIAENGGIH-------ELCKKLYTSPNEGLSGSKADE 61
            ||...:.||            .|.|...:.....|:|       |  |.|.|.|..||:   :||
Yeast    74 IDELQSNYG------------EGDESGEEEVRTDGVHAGQRVVPE--KDLSTDPAYGLT---SDE 121

  Fly    62 -EHRRETFGSNVIPPKPPK---TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQE 122
             ..||:.:|.|.:..:...   .||......:|    .::|.||:::.|||
Yeast   122 VARRRKKYGLNQMAEENESLIVKFLMFFVGPIQ----FVMEAAAILAAGLS-------------- 168

  Fly   123 EEEHHGWIEGLAILISVI-VVVIVTAFNDYSKERQFRGLQNRIEG--EHKFSVIRGGEVCQISVG 184
                 .|::     :.|| .::::.|...:.:|.|...:.:.::.  .:..:|||.|::.:|...
Yeast   169 -----DWVD-----VGVICALLLLNASVGFIQEFQAGSIVDELKKTLANTATVIRDGQLIEIPAN 223

  Fly   185 DILVGDIAQVKYGDLLPADGCLIQSN-DLKVDESSLTGESDHVKK--GPDVDPMVLSGTHVMEGS 246
            :::.|:|.|::.|.:.||||.::..: .|::|:|::||||...:|  |.:    |.|.:.|..|.
Yeast   224 EVVPGEILQLESGTIAPADGRIVTEDCFLQIDQSAITGESLAAEKHYGDE----VFSSSTVKTGE 284

  Fly   247 GKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPS 311
            ..|||||.|.|:..|....|:|.|
Yeast   285 AFMVVTATGDNTFVGRAAALVGQA----------------------------------------- 308

  Fly   312 QRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIIL 376
                                    ||.  .||          .|::...||.. ..:.|:..::|
Yeast   309 ------------------------SGV--EGH----------FTEVLNGIGII-LLVLVIATLLL 336

  Fly   377 IIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLV 441
            :...|....|            .:|..|...:.:.::.||.|||..||.::|.....:.|...:|
Yeast   337 VWTACFYRTV------------GIVSILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIV 389

  Fly   442 RHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNS 506
            :.|.|.|::.....:|||||||||.|::::.:.|..|
Yeast   390 QKLSAIESLAGVEILCSDKTGTLTKNKLSLHEPYTVE---------------------------- 426

  Fly   507 AYTSNIMAGHNPGDLPIQVGNKTECALL------------GFVQGLGVKYQSIRDEITEDKFTRV 559
                    |.:|.||.:     |.|...            .|::.| ::|...:|.:|:.|....
Yeast   427 --------GVSPDDLML-----TACLAASRKKKGLDAIDKAFLKSL-IEYPKAKDALTKYKVLEF 477

  Fly   560 YTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEK---FTRDMQERLIREVI 621
            :.|:.|.|.:..|:..|.|...:..|||...::|          |:|:   ...|:.|....:|.
Yeast   478 HPFDPVSKKVTAVVESPEGERIVCVKGAPLFVLK----------TVEEDHPIPEDVHENYENKVA 532

  Fly   622 EPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDA 686
            | :|..|.|.:.||.:              .||.:|:    |:..:.|:      ||.|.:....
Yeast   533 E-LASRGFRALGVARK--------------RGEGHWE----ILGVMPCM------DPPRDDTAQT 572

  Fly   687 IRKCQRAGITVRMVTGDNINTARSIASKCGI-----------LRPNDDFLILEGKEFNRRIRDSN 740
            |.:.:..|:.::|:|||.:..|:....:.|:           |....|   :.|.|....:.:::
Yeast   573 INEARNLGLRIKMLTGDAVGIAKETCRQLGLGTNIYNAERLGLGGGGD---MPGSELADFVENAD 634

  Fly   741 GDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENR-EVVAVTGDGTNDGPALKKADVG 804
            |                .|...|..||.:|:      :.:|| .:||:||||.||.|:|||||.|
Yeast   635 G----------------FAEVFPQHKYRVVE------ILQNRGYLVAMTGDGVNDAPSLKKADTG 677

  Fly   805 FAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGA-C 868
            .|:. ..||.|:.|:||:......|:|:.|:...|.::..:..::.:::.:::...|  |:|. .
Yeast   678 IAVE-GATDAARSAADIVFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEI--FLGLWI 739

  Fly   869 AVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQL 933
            |:.::.|....::::.:..| :|:|.:|.:              ..|.....:..|:  ..|:.:
Yeast   740 AILNNSLDINLIVFIAIFAD-VATLTIAYD--------------NAPYAPEPVKWNL--PRLWGM 787

  Fly   934 IIIFGLLFV--------------GDVILDIESGRG-QELNAGPTQHFTIIFNTFVMMTLFNEINA 983
            .||.|::..              |.:|.:..:..| ..|....|::: :||.|......::.|.:
Yeast   788 SIILGIVLAIGSWITLTTMFLPNGGIIQNFGAMNGVMFLQISLTENW-LIFVTRAAGPFWSSIPS 851

  Fly   984 RKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWG 1048
            .::.|....::.:.|....:..|.......|.:::.              |:|.|  ||..::.|
Yeast   852 WQLAGAVFAVDIIATMFTLFGWWSENWTDIVSVVRV--------------WIWSI--GIFCVLGG 900

Fly 1049 1048
Yeast 901 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	232/1105 (21%)
		Cation_ATPase_N	36..104	CDD:279080	21/78 (27%)
		E1-E2_ATPase	172..448	CDD:278548	62/278 (22%)
		Cation_ATPase	505..598	CDD:289987	22/104 (21%)
		HAD_like	676..807	CDD:119389	38/142 (27%)
		Cation_ATPase_C	873..1051	CDD:279079	30/191 (16%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
PMA2	NP_015289.1	P-type_ATPase_H	116..903	CDD:319771	219/1049 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930