Protein Alignment PMCA and PMA1

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_011507.1
• Gene: PMA1 / 852876
• SGDID: S000002976
• Length: 918
• Species: Saccharomyces cerevisiae
• Alignment Length: 1091
• Identity: 234/1091 - (21%)
• Similarity: 424/1091 - (38%)
• Gaps: 326/1091 - (29%)

  Fly    18 LRELMEHRG-------REGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEE-HRRETFGSNVIP 74
            :.||..:.|       .:|.:...|...:.|  :.|.|.|:.||:   :||. .||:.:|.|.:.
Yeast    47 IEELQSNHGVDDEDSDNDGPVAAGEARPVPE--EYLQTDPSYGLT---SDEVLKRRKKYGLNQMA 106

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISV 139
            .:.....:..|...:..:. .::|.||:::.|||                   .|::     ..|
Yeast   107 DEKESLVVKFVMFFVGPIQ-FVMEAAAILAAGLS-------------------DWVD-----FGV 146

  Fly   140 IV-VVIVTAFNDYSKERQFRGLQNRIEG--EHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLP 201
            |. ::::.|...:.:|.|...:.:.::.  .:...|||.|::.:|...:::.|||.|::.|.::|
Yeast   147 ICGLLMLNAGVGFVQEFQAGSIVDELKKTLANTAVVIRDGQLVEIPANEVVPGDILQLEDGTVIP 211

  Fly   202 ADGCLIQSN-DLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFT 265
            .||.::..: .|::|:|::||||..|.|  .......|.:.|..|.|.|||||.|.|       |
Yeast   212 TDGRIVTEDCFLQIDQSAITGESLAVDK--HYGDQTFSSSTVKRGEGFMVVTATGDN-------T 267

  Fly   266 LLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHL 330
            .:|.|              |...||
Yeast   268 FVGRA--------------AALVNK---------------------------------------- 278

  Fly   331 PQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNT 395
                  .|...||          .|::...||          :|:|::  .|.|.::   .|...
Yeast   279 ------AAGGQGH----------FTEVLNGIG----------IILLVL--VIATLLL---VWTAC 312

  Fly   396 Y--ANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICS 458
            :  .|.:|:.|...:.:.::.||.|||..||.::|.....:.|...:|:.|.|.|::.....:||
Yeast   313 FYRTNGIVRILRYTLGITIIGVPVGLPAVVTTTMAVGAAYLAKKQAIVQKLSAIESLAGVEILCS 377

  Fly   459 DKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPI 523
            |||||||.|::::.:.|..|                                    |.:|.||.:
Yeast   378 DKTGTLTKNKLSLHEPYTVE------------------------------------GVSPDDLML 406

  Fly   524 QVGNKTECALL------------GFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRP 576
                 |.|...            .|::.| .:|...:|.:|:.|....:.|:.|.|.:..|:..|
Yeast   407 -----TACLAASRKKKGLDAIDKAFLKSL-KQYPKAKDALTKYKVLEFHPFDPVSKKVTAVVESP 465

  Fly   577 NGGYRLYTKGASEIIMKKCAFIYGHEGTLEK---FTRDMQERLIREVIEPMACDGLRTISVAYRD 638
            .|...:..|||...::|          |:|:   ...|:.|....:|.| :|..|.|.:.||.:
Yeast   466 EGERIVCVKGAPLFVLK----------TVEEDHPIPEDVHENYENKVAE-LASRGFRALGVARK- 518

  Fly   639 FVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGD 703
                         .||.:|:    |:..:.|:      ||.|.:....:.:.:..|:.|:|:|||
Yeast   519 -------------RGEGHWE----ILGVMPCM------DPPRDDTAQTVSEARHLGLRVKMLTGD 560

  Fly   704 NINTARSIASKCGI-----------LRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRV 757
            .:..|:....:.|:           |....|   :.|.|....:.:::|
Yeast   561 AVGIAKETCRQLGLGTNIYNAERLGLGGGGD---MPGSELADFVENADG---------------- 606

  Fly   758 LARSSPTDKYTLVKGIIDSTVSENR-EVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDI 821
            .|...|..||.:|:      :.:|| .:||:||||.||.|:|||||.|.|:. ..||.|:.|:||
Yeast   607 FAEVFPQHKYRVVE------ILQNRGYLVAMTGDGVNDAPSLKKADTGIAVE-GATDAARSAADI 664

  Fly   822 ILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGA-CAVQDSPLKAVQMLWVNL 885
            :......|:|:.|:...|.::..:..::.:::.:::...|  |:|. .|:.|:.|....::::.:
Yeast   665 VFLAPGLSAIIDALKTSRQIFHRMYSYVVYRIALSLHLEI--FLGLWIAILDNSLDIDLIVFIAI 727

  Fly   886 IMDTLASLALATEFPTPDLLLRKPYGRTKPL---ISRTMMKNILGQALYQLIIIFGLLFV----- 942
            ..| :|:||:|.:        ..||. .||:   :.|          |:.:.||.|::..
Yeast   728 FAD-VATLAIAYD--------NAPYS-PKPVKWNLPR----------LWGMSIILGIVLAIGSWI 772

  Fly   943 ---------GDVILDIESGRG-QELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLL 997
                     |.:|.:..:..| ..|....|::: :||.|......::.|.:.::.|....::.:.
Yeast   773 TLTTMFLPKGGIIQNFGAMNGIMFLQISLTENW-LIFITRAAGPFWSSIPSWQLAGAVFAVDIIA 836

  Fly   998 TNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWG 1048
            |....:..|.......|.:::.              |:|.|  ||..::.|
Yeast   837 TMFTLFGWWSENWTDIVTVVRV--------------WIWSI--GIFCVLGG 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	234/1091 (21%)
		Cation_ATPase_N	36..104	CDD:279080	16/68 (24%)
		E1-E2_ATPase	172..448	CDD:278548	65/278 (23%)
		Cation_ATPase	505..598	CDD:289987	22/104 (21%)
		HAD_like	676..807	CDD:119389	38/142 (27%)
		Cation_ATPase_C	873..1051	CDD:279079	34/194 (18%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
PMA1	NP_011507.1	P-type_ATPase_H	87..874	CDD:319771	225/1049 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930