Protein Alignment PMCA and CCC2

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_010556.1
• Gene: CCC2 / 851862
• SGDID: S000002678
• Length: 1004
• Species: Saccharomyces cerevisiae
• Alignment Length: 1142
• Identity: 226/1142 - (19%)
• Similarity: 353/1142 - (30%)
• Gaps: 471/1142 - (41%)

  Fly    13 ISLKQLRELMEHRG----------------REGVMKIAENGGIHELCKKLYTSPNEGLSG----- 56
            ::...::|::|..|                :||::.:  .|.....|....|...||:.|
Yeast    50 VTADSIKEIIEDCGFDCEILRDSEITAISTKEGLLSV--QGMTCGSCVSTVTKQVEGIEGVESVV 112

  Fly    57 --------------SKADEEHRRET-----FGSNVI------PPKPPKTFLTLVWEALQDVTLII 96
                          ||...|..||.     |.||:|      .....||.:..|.:|.:|.:.:|
Yeast   113 VSLVTEECHVIYEPSKTTLETAREMIEDCGFDSNIIMDGNGNADMTEKTVILKVTKAFEDESPLI 177

  Fly    97 LEVAA-----LVSLGLSFYKPADE---------------------------------------DA 117
            |...:     |:.||:...:.:|:                                       ..
Yeast   178 LSSVSERFQFLLDLGVKSIEISDDMHTLTIKYCCNELGIRDLLRHLERTGYKFTVFSNLDNTTQL 242

  Fly   118 PVLQEEEEHHGWIEG------LAILISVIVVVIVTAFNDYSKERQF--------RGLQNR----- 163
            .:|.:|:|...|.:.      |||:..::.:::...:....::|.|        |||..|
Yeast   243 RLLSKEDEIRFWKKNSIKSTLLAIICMLLYMIVPMMWPTIVQDRIFPYKETSFVRGLFYRDILGV 307

  Fly   164 -IEGEHKFSV-----------IRGGE------VC------------------------------- 179
             :....:|||           ::.|.      ||
Yeast   308 ILASYIQFSVGFYFYKAAWASLKHGSGTMDTLVCVSTTCAYTFSVFSLVHNMFHPSSTGKLPRIV 372

  Fly   180 ---------QISVGDIL-------------------------------------------VGDIA 192
                     .||:|..|                                           |.||.
Yeast   373 FDTSIMIISYISIGKYLETLAKSQTSTALSKLIQLTPSVCSIISDVERNETKEIPIELLQVNDIV 437

  Fly   193 QVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVN 257
            ::|.|..:|||| :|...:.::|||.:||||..|.|        .:|..|:.||         ||
Yeast   438 EIKPGMKIPADG-IITRGESEIDESLMTGESILVPK--------KTGFPVIAGS---------VN 484

  Fly   258 SQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITK 322
            ......|.......:.:.|.|.|:.||
Yeast   485 GPGHFYFRTTTVGEETKLANIIKVMKE-------------------------------------- 511

  Fly   323 SESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAG--STIAVLTVIIL-IIQFCIKT 384
                                         |:|:|..|| |||.  ::|.|..::|| ::.|.|..
Yeast   512 -----------------------------AQLSKAPIQ-GYADYLASIFVPGILILAVLTFFIWC 546

  Fly   385 FV--IDEKP----WKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRH 443
            |:  |...|    ..||.|:|....|....:|::||.|..|.||...::........::..|::.
Yeast   547 FILNISANPPVAFTANTKADNFFICLQTATSVVIVACPCALGLATPTAIMVGTGVGAQNGVLIKG 611

  Fly   444 LDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAY 508
            .:..|...:.|....||||||||..|.|      :|..|
Yeast   612 GEVLEKFNSITTFVFDKTGTLTTGFMVV------KKFLK-------------------------- 644

  Fly   509 TSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVI 573
            .||            .|||..|..:|..::..    :||.|........|.....:..|::..|:
Yeast   645 DSN------------WVGNVDEDEVLACIKAT----ESISDHPVSKAIIRYCDGLNCNKALNAVV 693

  Fly   574 PRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDM---QERLIREVIEPMACDGLRTISVA 635
            ....     |..|..  |:.||. :.|:       |.|:   .|.||.|       |.|:.....
Yeast   694 LESE-----YVLGKG--IVSKCQ-VNGN-------TYDICIGNEALILE-------DALKKSGFI 736

  Fly   636 YRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVG---IEDPVRPEVPDAIRKCQRAGITV 697
            ..:...|. .::.|.::|.                 |.|   |.|.|:.:....::..||.|...
Yeast   737 NSNVDQGN-TVSYVSVNGH-----------------VFGLFEINDEVKHDSYATVQYLQRNGYET 783

  Fly   698 RMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSS 762
            .|:||||.:.|:.:|.:.||...|                                   |.:..|
Yeast   784 YMITGDNNSAAKRVAREVGISFEN-----------------------------------VYSDVS 813

  Fly   763 PTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDII----- 822
            ||.|..|||.|.|   .|....|||.|||.||.|||..:|:|.|:. .||::|.||:||:
Yeast   814 PTGKCDLVKKIQD---KEGNNKVAVVGDGINDAPALALSDLGIAIS-TGTEIAIEAADIVILCGN 874

  Fly   823 -LTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLI 886
             |..::...:..|:......:..|...|.:.|..|:..:.:|.            .|.:.|...:
Yeast   875 DLNTNSLRGLANAIDISLKTFKRIKLNLFWALCYNIFMIPIAM------------GVLIPWGITL 927

  Fly   887 MDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMK 923
            ...||.||:|             :.....::|..|:|
Yeast   928 PPMLAGLAMA-------------FSSVSVVLSSLMLK 951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	211/1054 (20%)
		Cation_ATPase_C	873..1051	CDD:376368	10/51 (20%)
		ATP_Ca_trans_C	1096..1141	CDD:463575
CCC2	NP_010556.1	HMA	6..67	CDD:238219	3/16 (19%)
		HMA	84..144	CDD:238219	11/61 (18%)
		P-type_ATPase_Cu-like	259..938	CDD:319783	188/916 (21%)