Protein Alignment PMCA and ACA1

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_849716.1
• Gene: ACA1 / 839670
• AraportID: AT1G27770
• Length: 1020
• Species: Arabidopsis thaliana
• Alignment Length: 1070
• Identity: 417/1070 - (38%)
• Similarity: 578/1070 - (54%)
• Gaps: 194/1070 - (18%)

  Fly     7 RPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSN 71
            |.|.:.|...:|..::|  |.: :.|:..:||...|.:||.||...|:|.|:.....|:|.:|.|
plant    92 RKAGFEICPDELGSIVE--GHD-LKKLKIHGGTEGLTEKLSTSIASGISTSEDLLSVRKEIYGIN 153

  Fly    72 VIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGW----IEG 132
            .....|.:.|...|||||||.||:||...|.|||.:.          :|.|     ||    .:|
plant   154 QFTESPSRGFWLFVWEALQDTTLMILAACAFVSLIVG----------ILME-----GWPIGAHDG 203

  Fly   133 LAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHK---FSVIRGGEVCQISVGDILVGDIAQV 194
            |.|:.|:::||.|||.:||.:..||:.|    :.|.|   ..|.|.....:||:.|:|.||:..:
plant   204 LGIVASILLVVFVTATSDYRQSLQFKDL----DAEKKKIVVQVTRDKLRQKISIYDLLPGDVVHL 264

  Fly   195 KYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQ 259
            ..||.:||||..|....:.::||||||||:.|....: .|.:||||.|.:||.||:||.||:.:|
plant   265 GIGDQIPADGLFISGFSVLINESSLTGESEPVSVSVE-HPFLLSGTKVQDGSCKMLVTTVGMRTQ 328

  Fly   260 AGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSE 324
            .|.:...|
plant   329 WGKLMATL--------------------------------------------------------- 336

  Fly   325 SEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDE 389
            |||.                .:::.||.||..:|..||..|...||:|..:| :|.......:|.
plant   337 SEGG----------------DDETPLQVKLNGVATIIGKIGLFFAVITFAVL-VQGLANQKRLDN 384

  Fly   390 KPWKNTYANNL---VKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            ..|..| |:.|   :::..:.||::|||||||||||||||||:::||||.|..|||:|.||||||
plant   385 SHWIWT-ADELMAMLEYFAVAVTIVVVAVPEGLPLAVTLSLAFAMKKMMNDKALVRNLAACETMG 448

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKV------LPTLSDIPQHVGNLITMGISVNSAYTS 510
            :||.||||||||||||.||||::.|||:..:|      :...|.||:....|:...|..|:.
plant   449 SATTICSDKTGTLTTNHMTVVKACICEQAKEVNGPDAAMKFASGIPESAVKLLLQSIFTNTG--- 510

  Fly   511 NIMAGHNPGDLPIQVGNK-------TECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKS 568
                    |::.:..|||       ||.|||.|...||..:|.:|.   .....:|..|||.:|.
plant   511 --------GEIVVGKGNKTEILGTPTETALLEFGLSLGGDFQEVRQ---ASNVVKVEPFNSTKKR 564

  Fly   569 MGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTL----EKFTRDMQERLIREVIEPMACDGL 629
            ||.||..|...:|.:.||||||::..|......:|.:    ||.|..     ::.:||..|.:.|
plant   565 MGVVIELPERHFRAHCKGASEIVLDSCDKYINKDGEVVPLDEKSTSH-----LKNIIEEFASEAL 624

  Fly   630 RTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNL-----TCLCVVGIEDPVRPEVPDAIRK 689
            ||:.:||.:.                  .||.::...:     ||:.:|||:|||||.|.:::..
plant   625 RTLCLAYFEI------------------GDEFSLEAPIPSGGYTCIGIVGIKDPVRPGVKESVAI 671

  Fly   690 CQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPK 754
            |:.||||||||||||:.||::||.:||||  .||.:.:||.||..:       ..:.|: |:.||
plant   672 CKSAGITVRMVTGDNLTTAKAIARECGIL--TDDGIAIEGPEFREK-------SDEELL-KLIPK 726

  Fly   755 LRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEAS 819
            |:|:|||||.||:|||:  :..|:.:  ||||||||||||.|||.:||:|.||||:||:||||::
plant   727 LQVMARSSPMDKHTLVR--LLRTMFQ--EVVAVTGDGTNDAPALHEADIGLAMGISGTEVAKESA 787

  Fly   820 DIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVN 884
            |:|:.|||||:||....|||:||.:|.||:||||||||||:||.|:.||...::||.|||:||||
plant   788 DVIILDDNFSTIVTVAKWGRSVYINIQKFVQFQLTVNVVALIVNFLSACLTGNAPLTAVQLLWVN 852

  Fly   885 LIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDI 949
            :|||||.:||||||.|..||:.|.|.||....||..|.:|||||:||||:||:.|...|..:..:
plant   853 MIMDTLGALALATEPPQDDLMKRSPVGRKGNFISNVMWRNILGQSLYQLVIIWCLQTKGKTMFGL 917

  Fly   950 ESGRGQELNAGPTQHF---TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMI 1011
            :         ||....   |:|||.||...:||||::|::. :.:|.:|:|.|.:|..:...|::
plant   918 D---------GPDSDLTLNTLIFNIFVFCQVFNEISSREME-KIDVFKGILKNYVFVAVLTCTVV 972

  Fly  1012 SQVLIIQYGKMAFSTKALTLDQWLWCIFFG 1041
            .||:||:.......|..|.|.|||..|..|
plant   973 FQVIIIELLGTFADTTPLNLGQWLVSIILG 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	355/890 (40%)
		Cation_ATPase_C	873..1051	CDD:376368	74/172 (43%)
		ATP_Ca_trans_C	1096..1141	CDD:463575
ACA1	NP_849716.1	CaATP_NAI	5..50	CDD:432606
		ATPase-IIB_Ca	59..1017	CDD:273668	417/1070 (39%)