DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and AT5G53010

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_200113.3	Gene:	AT5G53010 / 835380	AraportID:	AT5G53010	Length:	1049	Species:	Arabidopsis thaliana

Alignment Length:	1073	Identity:	310/1073 - (28%)
Similarity:	482/1073 - (44%)	Gaps:	200/1073 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEE--HRRETFGSNVI 73
            :||.:::|.:|::.|..|.:.:.   .|:|.|...|.|....|:  .:.|:|  .||..:|||..
plant   140 FGIGVEELVQLVKERSLEALNRY---NGVHGLSNLLKTDLKVGI--DRRDDEILLRRNAYGSNTY 199

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGW-IEGLAILI 137
            |.|..|||...:|.|.|...|:::..||:....|........|           || ||...:|:
plant   200 PCKKGKTFWYFLWRASQFSHLLVIMFAAVFFSLLRIKTKGILD-----------GWYIEACIVLV 253

  Fly   138 SVIVVVIVTAFNDYSKERQFRGLQNRIEGEHK----FSVIRGGEVCQISVGDILVGDIAQVKYGD 198
            :|..::.: |..:|.:..:|..|.     |.|    ..|||||...::|:.||:||||..:|.|.
plant   254 TVFHIIAI-AVAEYKQSCRFIKLT-----EEKRTVYLEVIRGGRRVRVSIYDIVVGDIVPLKNGC 312

  Fly   199 LLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGII 263
            .:||||.|..:|.|||.|..:|...:.|:|....:|.:|||:.::||.|.|:||:||:|::.|:.
plant   313 QVPADGVLFVANSLKVAEQEVTASDEIVQKDLQTNPFLLSGSKLIEGIGTMLVTSVGMNTEWGLK 377

  Fly   264 FTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQR-------ETVTSEIT 321
            .. :....||::.....:|..|..|:....|........|:.||.|||.:       ....|.:|
plant   378 ME-VSQKTDEEKPFQGYLKWLAISASWFVVLFASVACSIQVGGSSAPSWQGPNNRFISRYFSGVT 441

  Fly   322 KSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFV 386
            | :|:|..:                                    .|..:|.....|:|.|.:
plant   442 K-KSDGTPM------------------------------------FIYGITTADEAIEFVITS-- 467

  Fly   387 IDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
                             |..|:..:|||||.||.:||.|:.|.:.|||.||..|
plant   468 -----------------LSFGIATIVVAVPVGLSIAVRLNFAKTTKKMRKDKVL----------- 504

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
                             |:||..:......:.:..:|.:|..:..||..||:.|   |:..:...
plant   505 -----------------MSVVDVWAGGIRMQDMDDVSQLPTFLKELIIEGIAQN---TNGSVVFE 549

  Fly   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR 581
            .....|...|:.||.|:|.|...||:|:...|   :.........||..:|..|..:......:
plant   550 TGVTEPEVYGSPTEQAILNFGNKLGMKFDDAR---SASLVRHTIPFNPKKKYGGVALQLGTHAH- 610

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLE-----KFTRDMQERLIREVIEPMACDGLRTISVAYRDFVP 641
            ::.||:::.|:..|      ||.::     :...:.:.:.....||.|:.:|||..::||:
plant   611 VHWKGSAKTILSSC------EGYMDGANNSRAINEQKRKSFEGTIENMSKEGLRCAALAYQ---- 665

  Fly   642 GKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNIN 706
             ...:..:....||.         ||..|.:|||:||.||...|||:.|....:.|.|||.::..
plant   666 -PCELGSLPTITEPR---------NLVLLAIVGIKDPCRPGTRDAIQLCNSGSVKVCMVTDNDGL 720

  Fly   707 TARSIASKCGILRPNDDFLILEGKEFNRRIRDSN-----GDIQQHLIDKVWPKLRVLARSSPTDK 766
            ||::||.:||||.......|..|.:| |.:.|..     |||            .|.|:|||.|.
plant   721 TAQAIAIECGILTDASGRNIRTGAQF-RELSDLEREQIAGDI------------LVFAQSSPNDN 772

  Fly   767 YTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 831
            ..||:.:     .:...:||.||.|.:|...|::|||..|||:.||..|||.||.|:.||||::|
plant   773 LLLVQAL-----KKRGHIVAATGMGIHDPKTLREADVSLAMGVGGTAAAKENSDFIILDDNFATI 832

  Fly   832 VKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALA 896
            ||.::|.|::|:::.|.:.|:|||:|.|:.|..:........||.|||.|.||||:|.|.:||||
plant   833 VKCIIWSRSLYNNVQKSILFRLTVSVSALAVCVVEVVVYDAFPLNAVQFLLVNLIIDILGALALA 897

  Fly   897 TEFPTPD--LLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNA 959
            .. |..|  |:.:.|.|...|||::||...::.|..|   ::..|:.:....| ::...||..||
plant   898 YR-PRSDHHLMGKPPVGIRDPLITKTMWSKMIIQVFY---LVLSLVLINSEKL-LKLKHGQTGNA 957

  Fly   960 GPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAF 1024
            ....: |:|||:||...:|||...:.:  .:...|.|..|....|| ..|:|||:::|:     |
plant   958 EKMMN-TLIFNSFVFYLVFNEFEIQSV--DQTFKEVLRENMFLVTI-TSTIISQIIVIK-----F 1013

  Fly  1025 STKALTLDQWLWCIFFGIGTLVWGQLITSVPTR 1057
            :...:.|.:|:.....|        |::.|.||
plant  1014 AGIFIDLKKWVTTSLLG--------LLSQVATR 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	308/1071 (29%)
		Cation_ATPase_N	36..104	CDD:279080	24/69 (35%)
		E1-E2_ATPase	172..448	CDD:278548	82/282 (29%)
		Cation_ATPase	505..598	CDD:289987	21/92 (23%)
		HAD_like	676..807	CDD:119389	46/135 (34%)
		Cation_ATPase_C	873..1051	CDD:279079	57/179 (32%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
AT5G53010	NP_200113.3	ATPase-IIB_Ca	128..1035	CDD:273668	307/1068 (29%)
		Cation_ATPase_N	164..228	CDD:279080	23/65 (35%)
		E1-E2_ATPase	286..504	CDD:278548	81/274 (30%)
		Cation_ATPase	549..624	CDD:289987	18/78 (23%)
		COG4087	<763..826	CDD:226572	29/67 (43%)
		Cation_ATPase_C	875..>998	CDD:279079	46/130 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	91	1.000	Domainoid score	I2611
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.690