DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ACA10

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001327988.1	Gene:	ACA10 / 829112	AraportID:	AT4G29900	Length:	1069	Species:	Arabidopsis thaliana

Alignment Length:	1079	Identity:	404/1079 - (37%)
Similarity:	601/1079 - (55%)	Gaps:	149/1079 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPP 75
            :||..:|:..:...   :.:..:.|.||:..|...|.|:..:|:.|...|...|:..||||..|.
plant   114 FGIGQEQIVSISRD---QNIGALQELGGVRGLSDLLKTNLEKGIHGDDDDILKRKSAFGSNTYPQ 175

  Fly    76 KPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVI 140
            |..::|...||||.||:|||||.|||:.||.|.           ::.|....||.:|::|..:|:
plant   176 KKGRSFWRFVWEASQDLTLIILIVAAVASLALG-----------IKTEGIEKGWYDGISIAFAVL 229

  Fly   141 VVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGC 205
            :|::|||.:||.:..||:.| |..:...:..|.|.|...:||:.||:|||:..:..||.:||||.
plant   230 LVIVVTATSDYRQSLQFQNL-NEEKRNIRLEVTRDGRRVEISIYDIVVGDVIPLNIGDQVPADGV 293

  Fly   206 LIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAA 270
            |:..:.|.|||||:||||..|:|.....|.::||..|.:|:|.|:||.||||::.|    ||.|:
plant   294 LVAGHSLAVDESSMTGESKIVQKNSTKHPFLMSGCKVADGNGTMLVTGVGVNTEWG----LLMAS 354

  Fly   271 VDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSS 335
            |                                                   ||..|...|
plant   355 V---------------------------------------------------SEDNGGETP---- 364

  Fly   336 SGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCI---------KTFVIDEKP 391
                          ||.:|..:|..||..|.|:|.:.:.:|::::..         ..|:..:..
plant   365 --------------LQVRLNGVATFIGIVGLTVAGVVLFVLVVRYFTGHTKNEQGGPQFIGGKTK 415

  Fly   392 WKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAI 456
            :::. .::||:...:.||::||||||||||||||:||||::|||.|..|||.|.||||||:||.|
plant   416 FEHV-LDDLVEIFTVAVTIVVVAVPEGLPLAVTLTLAYSMRKMMADKALVRRLSACETMGSATTI 479

  Fly   457 CSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDL 521
            |||||||||.|.||||:.|...:......:.|.:|....:::..||:.|:  |.::....: |::
plant   480 CSDKTGTLTLNEMTVVECYAGLQKMDSPDSSSKLPSAFTSILVEGIAHNT--TGSVFRSES-GEI 541

  Fly   522 PIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKG 586
            .:. |:.||.|:|.:...||:.:.:::.|.:..:|   :.|||.:|..|..:..|:....::.||
plant   542 QVS-GSPTERAILNWAIKLGMDFDALKSESSAVQF---FPFNSEKKRGGVAVKSPDSSVHIHWKG 602

  Fly   587 ASEIIMKKCAFIYGHEGTLEKFTRDMQERL--IREVIEPMACDGLRTISVAYRDFVPGKAAINEV 649
            |:||::..|.. |..|.  |.|....::::  :::.|:.||...||.:::|:|.|...|...:|.
plant   603 AAEIVLGSCTH-YMDES--ESFVDMSEDKMGGLKDAIDDMAARSLRCVAIAFRTFEADKIPTDEE 664

  Fly   650 HIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASK 714
            .:.   .|:..|:   :|..|.:|||:||.||.|.:::..||:||:.|||||||||.||::||.:
plant   665 QLS---RWELPED---DLILLAIVGIKDPCRPGVKNSVLLCQQAGVKVRMVTGDNIQTAKAIALE 723

  Fly   715 CGILRPNDDFL---ILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            ||||..:.|..   ::|||.|.....:..        |::..::.|:.||||.||..||:
plant   724 CGILASDSDASEPNLIEGKVFRSYSEEER--------DRICEEISVMGRSSPNDKLLLVQ----- 775

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            ::.....|||||||||||.|||.:||:|.||||.||:||||.||||:.||||.|:||.|.|||:|
plant   776 SLKRRGHVVAVTGDGTNDAPALHEADIGLAMGIQGTEVAKEKSDIIILDDNFESVVKVVRWGRSV 840

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            |.:|.||:||||||||.|:::..:.|.:..:.||.|||:||||||||||.:||||||.||..|:.
plant   841 YANIQKFIQFQLTVNVAALVINVVAAISAGEVPLTAVQLLWVNLIMDTLGALALATEPPTDHLMD 905

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            |.|.||.:|||:..|.:|:..||:||:.::..|.|.|..||.::|    :.||...:: |:|||.
plant   906 RAPVGRREPLITNIMWRNLFIQAMYQVTVLLILNFRGISILHLKS----KPNAERVKN-TVIFNA 965

  Fly   972 FVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQY-GKMAFSTKALTLDQWL 1035
            ||:..:|||.|||| ..:.|:..|:|.|.:|..|...|::.||:|::: |..|.:|| |..:.||
plant   966 FVICQVFNEFNARK-PDEINIFRGVLRNHLFVGIISITIVLQVVIVEFLGTFASTTK-LDWEMWL 1028

  Fly  1036 WCIFFGIGTLVW-----GQLI--TSVPTRKLPKILSWGR 1067
            .||  |||::.|     |:||  ...|..:..:|..|.|
plant  1029 VCI--GIGSISWPLAVIGKLIPVPETPVSQYFRINRWRR 1065

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	401/1067 (38%)
		Cation_ATPase_N	36..104	CDD:279080	30/67 (45%)
		E1-E2_ATPase	172..448	CDD:278548	93/284 (33%)
		Cation_ATPase	505..598	CDD:289987	24/92 (26%)
		HAD_like	676..807	CDD:119389	58/133 (44%)
		Cation_ATPase_C	873..1051	CDD:279079	82/183 (45%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ACA10	NP_001327988.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	140	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I150
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm3001
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840