DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and AT3G22910

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_188931.1	Gene:	AT3G22910 / 821863	AraportID:	AT3G22910	Length:	1017	Species:	Arabidopsis thaliana

Alignment Length:	1079	Identity:	386/1079 - (35%)
Similarity:	580/1079 - (53%)	Gaps:	170/1079 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPP 75
            :.|..:.|.:|::::.:|   |:...||.:.|...|.::...|::....:.:.||.|||||....
plant    81 FKIDTETLNDLVKNKNQE---KLESLGGPNGLVSALKSNTRLGINEEGDEIQRRRSTFGSNTYTR 142

  Fly    76 KPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVI 140
            :|.|.....|.||.:|:|::||...|.:|||..           ::|.....||.:|.:|.::|.
plant   143 QPSKGLFHFVVEAFKDLTILILLGCATLSLGFG-----------IKEHGLKEGWYDGGSIFVAVF 196

  Fly   141 VVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGC 205
            :||.|:|.:::.:.|||..| :::....|..|:|.|...:||:.||:||||..:..||.:||||.
plant   197 LVVAVSAVSNFRQNRQFDKL-SKVSSNIKIDVVRNGRRQEISIFDIVVGDIVCLNIGDQVPADGV 260

  Fly   206 LIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAA 270
            .::.:.|.|||||:|||||||:.....:..:.|||.:.:|.|||.||:||:|:..|.:.
plant   261 FVEGHLLHVDESSMTGESDHVEVSLTGNTFLFSGTKIADGFGKMAVTSVGMNTAWGQMM------ 319

  Fly   271 VDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSS 335
                                                                     :|:.:.::
plant   320 ---------------------------------------------------------SHISRDTN 327

  Fly   336 SGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCI--------------KTFV 386
                      |::.||::|.||...||..|..:|.|.:::|:|::..              ||..
plant   328 ----------EQTPLQSRLDKLTSSIGKVGLLVAFLVLLVLLIRYFTGTTKDESGNREYNGKTTK 382

  Fly   387 IDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            .||      ..|.:||.:...||::|||:||||||||||:||||:|:|||||.:||.|.||||||
plant   383 SDE------IVNAVVKMVAAAVTIIVVAIPEGLPLAVTLTLAYSMKRMMKDNAMVRKLSACETMG 441

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
            :||.||:|||||||.|:|.|...:...:..|.    |.:.|.|..|...|:::|:  |.::....
plant   442 SATVICTDKTGTLTLNQMKVTDFWFGLESGKA----SSVSQRVVELFHQGVAMNT--TGSVFKAK 500

  Fly   517 NPGDLPIQVGNKTECALLGF-VQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGY 580
            ...:.... |:.||.|:|.: |:.|.:..:.:   |.|.....|..|||.:|..|.::.:.....
plant   501 AGTEYEFS-GSPTEKAILSWAVEELEMGMEKV---IEEHDVVHVEGFNSEKKRSGVLMKKKGVNT 561

  Fly   581 R---LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPG 642
            .   ::.|||:|.|:..|:......|.:.:...| .:....::|:.||...||.|:.||
plant   562 ENNVVHWKGAAEKILAMCSTFCDGSGVVREMKED-DKIQFEKIIQSMAAKSLRCIAFAY------ 619

  Fly   643 KAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINT 707
                      .|.|.|:::.....|:.|.::||:||.||.|..|:..||.||:.::|:|||||.|
plant   620 ----------SEDNEDNKKLKEEKLSLLGIIGIKDPCRPGVKKAVEDCQFAGVNIKMITGDNIFT 674

  Fly   708 ARSIASKCGILRPNDDF---LILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTL 769
            ||:||.:||||.|.|:.   .:|||::|...       .|:..::|| .:::|:|||||.||..:
plant   675 ARAIAVECGILTPEDEMNSEAVLEGEKFRNY-------TQEERLEKV-ERIKVMARSSPFDKLLM 731

  Fly   770 VKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKA 834
            ||     .:.|...|||||||||||.||||:||:|.:|||.||:||||:|||::.||||:|:...
plant   732 VK-----CLKELGHVVAVTGDGTNDAPALKEADIGLSMGIQGTEVAKESSDIVILDDNFASVATV 791

  Fly   835 VMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEF 899
            :.|||.||::|.||:||||||||.|:::.|:.|.:..|.||.|||:||||||||||.:||||||.
plant   792 LKWGRCVYNNIQKFIQFQLTVNVAALVINFVAAVSAGDVPLTAVQLLWVNLIMDTLGALALATEK 856

  Fly   900 PTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDI-ESGRGQELNAGPTQ 963
            ||.||:.:||.||..|||:..|.:|:|.||.||:.::..|.|.|..|.:: |..:.
plant   857 PTNDLMKKKPIGRVAPLITNIMWRNLLAQAFYQISVLLVLQFRGRSIFNVTEKVKN--------- 912

  Fly   964 HFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKA 1028
              |:||||||:..:|||.|||.:. ::||.:||..|.:|..|.:.|::.||:::::.|....|:.
plant   913 --TLIFNTFVLCQVFNEFNARSLE-KKNVFKGLHKNRLFIGIIVVTVVLQVVMVEFLKRFADTER 974

  Fly  1029 LTLDQWLWCIFFGIGTLVWGQLITSVPT--RKLPKILSW 1065
            |.|.||..||.....:...|.|:.|||.  |.....|.|
plant   975 LNLGQWGVCIAIAAASWPIGWLVKSVPVPERHFFSYLKW 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	383/1069 (36%)
		Cation_ATPase_N	36..104	CDD:279080	22/67 (33%)
		E1-E2_ATPase	172..448	CDD:278548	93/289 (32%)
		Cation_ATPase	505..598	CDD:289987	23/96 (24%)
		HAD_like	676..807	CDD:119389	63/133 (47%)
		Cation_ATPase_C	873..1051	CDD:279079	76/178 (43%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
AT3G22910	NP_188931.1	HAD_like	128..878	CDD:389748	325/880 (37%)
AT3G22910	NP_188931.1	Cation_ATPase_C	830..998	CDD:376368	77/179 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	140	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I150
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm3001
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.840