DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ACA4

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_181687.1	Gene:	ACA4 / 818754	AraportID:	AT2G41560	Length:	1030	Species:	Arabidopsis thaliana

Alignment Length:	1091	Identity:	421/1091 - (38%)
Similarity:	600/1091 - (54%)	Gaps:	178/1091 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TIDGRPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRET 67
            |.:.:.|.:.|...:|..::.   :.....:|:.||:.||.||:..|.:||:..|:.  ..|.:.
plant    85 TDEVKKAGFSIEADELASMVR---KNDTKSLAQKGGVEELAKKVSVSLSEGIRSSEV--PIREKI 144

  Fly    68 FGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEG 132
            ||.|....||.::||..|||||.|:|||||.|.|:||:|:..   |.|..|        .|..:|
plant   145 FGENRYTEKPARSFLMFVWEALHDITLIILMVCAVVSIGVGV---ATEGFP--------RGMYDG 198

  Fly   133 LAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYG 197
            ..||:|:::||:|||.:||.:..|||.| :|.:.:....|.|.|...:||:.|::|||:..:..|
plant   199 TGILLSILLVVMVTAISDYKQSLQFRDL-DREKKKIIVQVTRDGSRQEISIHDLVVGDVVHLSIG 262

  Fly   198 DLLPADGCLIQSNDLKVDESSLTGESD--HVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQA 260
            |.:||||..|...:|::|||||:|||:  ||.|   ..|.:||||.|..||.||:||.||:.::.
plant   263 DQVPADGIFISGYNLEIDESSLSGESEPSHVNK---EKPFLLSGTKVQNGSAKMLVTTVGMRTEW 324

  Fly   261 G-IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSE 324
            | ::.||:....||
plant   325 GKLMETLVDGGEDE--------------------------------------------------- 338

  Fly   325 SEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDE 389
                                   :.||.||..:|..||..|.:.||||.::|    ||: ||:|:
plant   339 -----------------------TPLQVKLNGVATIIGKIGLSFAVLTFVVL----CIR-FVLDK 375

  Fly   390 KP------WKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACE 448
            ..      |.:..|..|:.:..|.||::|||||||||||||||||:::||:|.|..|||||.|||
plant   376 ATSGSFTNWSSEDALTLLDYFAISVTIIVVAVPEGLPLAVTLSLAFAMKKLMSDRALVRHLAACE 440

  Fly   449 TMGNATAICSDKTGTLTTNRMTVVQSYICEKL------CKVLPTLSDIPQHVGNLITMGISVNSA 507
            |||::|.||:|||||||||.|.|.:.:||:|:      .|....| ::.:.|.:.:..||..|
plant   441 TMGSSTCICTDKTGTLTTNHMVVNKVWICDKVQERQEGSKESFEL-ELSEEVQSTLLQGIFQN-- 502

  Fly   508 YTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTV 572
             |.:.:.....|:..| :|:.||.|:|.|...||..:.:.|   .|.|..::..|||.:|.|..:
plant   503 -TGSEVVKDKDGNTQI-LGSPTERAILEFGLLLGGDFNTQR---KEHKILKIEPFNSDKKKMSVL 562

  Fly   573 IPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERL--IREVIEPMACDGLRTISVA 635
            |..|.||.|.:.||||||::|.|..:....|.....|   :||:  |.::||..|.:.|||:.:.
plant   563 IALPGGGARAFCKGASEIVLKMCENVVDSNGESVPLT---EERITSISDIIEGFASEALRTLCLV 624

  Fly   636 YRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMV 700
            |:|            :|..|:.:..:.   ..|.:.||||:|||||.|.:|::.||.||||||||
plant   625 YKD------------LDEAPSGELPDG---GYTMVAVVGIKDPVRPGVREAVQTCQAAGITVRMV 674

  Fly   701 TGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTD 765
            |||||:||::||.:|||.  .:..|.:||.||.        |:..|.:..:.||::|:|||.|.|
plant   675 TGDNISTAKAIAKECGIY--TEGGLAIEGSEFR--------DLSPHEMRAIIPKIQVMARSLPLD 729

  Fly   766 KYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSS 830
            |:|||     |.:.:..||||||||||||.|||.:||:|.|||||||:||||.:|:|:.||||.:
plant   730 KHTLV-----SNLRKIGEVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKENADVIIMDDNFKT 789

  Fly   831 IVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLAL 895
            ||....|||.||.:|.||:||||||||||:|:.|:.||....:||.|||:||||:|||||.:|||
plant   790 IVNVARWGRAVYINIQKFVQFQLTVNVVALIINFVSACITGSAPLTAVQLLWVNMIMDTLGALAL 854

  Fly   896 ATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAG 960
            |||.|...|:.|.|..||...|::||.:||.||::||||::..|.|.|..:|.::         |
plant   855 ATEPPNEGLMKRAPIARTASFITKTMWRNIAGQSVYQLIVLGILNFAGKSLLKLD---------G 910

  Fly   961 PTQHF---TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKM 1022
            |....   |:|||:||...:|||||:|:|. :.||.:|:..:.:|..:...|::.||:|:::...
plant   911 PDSTAVLNTVIFNSFVFCQVFNEINSREIE-KINVFKGMFNSWVFTWVMTVTVVFQVIIVEFLGA 974

  Fly  1023 AFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEY 1073
            ..||..|:...||..|..|...::...::..||..        .|.|.:.|
plant   975 FASTVPLSWQHWLLSILIGSLNMIVAVILKCVPVE--------SRHHHDGY 1017

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	418/1073 (39%)
		Cation_ATPase_N	36..104	CDD:279080	31/67 (46%)
		E1-E2_ATPase	172..448	CDD:278548	98/284 (35%)
		Cation_ATPase	505..598	CDD:289987	33/92 (36%)
		HAD_like	676..807	CDD:119389	67/130 (52%)
		Cation_ATPase_C	873..1051	CDD:279079	71/180 (39%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ACA4	NP_181687.1	CaATP_NAI	4..48	CDD:289295
		ATPase-IIB_Ca	57..1009	CDD:273668	418/1073 (39%)
		Cation_ATPase_N	115..181	CDD:279080	31/67 (46%)
		E1-E2_ATPase	201..440	CDD:278548	113/321 (35%)
		Cation_ATPase	502..588	CDD:289987	33/92 (36%)
		COG4087	<716..784	CDD:226572	44/72 (61%)
		Cation_ATPase_C	833..1004	CDD:279079	71/180 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	140	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I150
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm3001
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840