DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ACA7

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_179879.1	Gene:	ACA7 / 816826	AraportID:	AT2G22950	Length:	1015	Species:	Arabidopsis thaliana

Alignment Length:	1055	Identity:	424/1055 - (40%)
Similarity:	579/1055 - (54%)	Gaps:	164/1055 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 RPAQYGISLKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADE-EHRRETFGS 70
            :.|.:.|...:|..::|  |.: |.|:..:||:..|..||...||.|||..:.:: ..|:|.||.
plant    90 KAAGFDICADELGSIVE--GHD-VKKLKFHGGVDGLSGKLKACPNAGLSTGEPEQLSKRQELFGI 151

  Fly    71 NVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAI 135
            |.......::|...|||||||:||:||.|.|.|||.:..   |.|..|        .|..:||.|
plant   152 NKFAESELRSFWVFVWEALQDMTLMILGVCAFVSLIVGI---ATEGWP--------QGSHDGLGI 205

  Fly   136 LISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHK---FSVIRGGEVCQISVGDILVGDIAQVKYG 197
            :.|:::||.|||.:||.:..|||.|    :.|.|   ..|.|.|...::|:.|:|.||:..:..|
plant   206 VASILLVVFVTATSDYRQSLQFRDL----DKEKKKITVQVTRNGFRQKMSIYDLLPGDVVHLAIG 266

  Fly   198 DLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGI 262
            |.:||||..:....:.:|||||||||:.|..... :|.:||||.|.:||.||:||.||:.:|.|.
plant   267 DQVPADGLFLSGFSVVIDESSLTGESEPVMVTAQ-NPFLLSGTKVQDGSCKMLVTTVGMRTQWGK 330

  Fly   263 IFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEG 327
            :...|                                                         |||
plant   331 LMATL---------------------------------------------------------SEG 338

  Fly   328 NHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII-QFCIKTFVIDEKP 391
            .                .:::.||.||..:|..||..|.:.|::|..:|:. .|..|..:.....
plant   339 G----------------DDETPLQVKLNGVATIIGKIGLSFAIVTFAVLVQGMFMRKLSLGPHWW 387

  Fly   392 WKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAI 456
            |....|..|:::..|.||::|||||||||||||||||:::||||.|..|||||.||||||:||.|
plant   388 WSGDDALELLEYFAIAVTIVVVAVPEGLPLAVTLSLAFAMKKMMNDKALVRHLAACETMGSATTI 452

  Fly   457 CSDKTGTLTTNRMTVVQSYIC----EKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHN 517
            |||||||||||.||||:|.||    :...|.....||||:....|:...|..|   |...:..:.
plant   453 CSDKTGTLTTNHMTVVKSCICMNVQDVASKSSSLQSDIPEAALKLLLQLIFNN---TGGEVVVNE 514

  Fly   518 PGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGG-YR 581
            .|...| :|..||.|:|.....||.|:|   :|...:|..:|..|||.:|.||.||..|.|| .|
plant   515 RGKTEI-LGTPTETAILELGLSLGGKFQ---EERQSNKVIKVEPFNSTKKRMGVVIELPEGGRIR 575

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            .:|||||||::..|..:....|.:.... |...:.:...|:..|.:.|||:.:||.|...|.:|
plant   576 AHTKGASEIVLAACDKVINSSGEVVPLD-DESIKFLNVTIDEFANEALRTLCLAYMDIESGFSA- 638

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
                        ||.......||:.:|||:|||||.|.:::..|:||||.||||||||||||::|
plant   639 ------------DEGIPEKGFTCIGIVGIKDPVRPGVRESVELCRRAGIMVRMVTGDNINTAKAI 691

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |.:||||  .||.:.:||..|    |:.|   |:.:::.: ||::|:|||||.||:||||.:  .
plant   692 ARECGIL--TDDGIAIEGPVF----REKN---QEEMLELI-PKIQVMARSSPMDKHTLVKQL--R 744

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            |..:  ||||||||||||.|||.:||:|.|||||||:||||.:|:|:.|||||:||....|||:|
plant   745 TTFD--EVVAVTGDGTNDAPALHEADIGLAMGIAGTEVAKEIADVIILDDNFSTIVTVAKWGRSV 807

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            |.:|.||:||||||||||:||.|..||....:||.|||:||||:|||||.:||||||.|..:|:.
plant   808 YINIQKFVQFQLTVNVVALIVNFSSACLTGSAPLTAVQLLWVNMIMDTLGALALATEPPNNELMK 872

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIII----------FGLLFVGDVILDIESGRGQELNAGP 961
            |.|.||....|:..|.:||||||:||.|||          |||:.....::         ||
plant   873 RMPVGRRGNFITNAMWRNILGQAVYQFIIIWILQAKGKSMFGLVGSDSTLV---------LN--- 925

  Fly   962 TQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFST 1026
                |:|||.||...:|||:::|::. :.:|.:|:|.|.:|..:...|:..|::||::.....||
plant   926 ----TLIFNCFVFCQVFNEVSSREME-EIDVFKGILDNYVFVVVIGATVFFQIIIIEFLGTFAST 985

  Fly  1027 KALTLDQWLWCIFFG 1041
            ..||:.||.:.||.|
plant   986 TPLTIVQWFFSIFVG 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	424/1055 (40%)
		Cation_ATPase_N	36..104	CDD:279080	29/68 (43%)
		E1-E2_ATPase	172..448	CDD:278548	91/276 (33%)
		Cation_ATPase	505..598	CDD:289987	36/93 (39%)
		HAD_like	676..807	CDD:119389	70/130 (54%)
		Cation_ATPase_C	873..1051	CDD:279079	72/179 (40%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ACA7	NP_179879.1	CaATP_NAI	5..49	CDD:289295
		ATPase-IIB_Ca	99..1015	CDD:273668	422/1046 (40%)
		Cation_ATPase_N	116..185	CDD:279080	29/68 (43%)
		E1-E2_ATPase	205..444	CDD:278548	106/316 (34%)
		Cation_ATPase	504..592	CDD:289987	36/94 (38%)
		HAD_like	659..773	CDD:119389	68/127 (54%)
		Cation_ATPase_C	840..1013	CDD:279079	72/178 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	140	1.000	Domainoid score	I1531
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	673	1.000	Inparanoid score	I150
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm3001
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840