DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp2b1

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001346435.1	Gene:	Atp2b1 / 67972	MGIID:	104653	Length:	1249	Species:	Mus musculus

Alignment Length:	1292	Identity:	750/1292 - (58%)
Similarity:	907/1292 - (70%)	Gaps:	134/1292 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ATIDGRPAQYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRR 65
            |..||   .:||:|.:||.|||.|..:.:.||.|: |.::.:|.||.|||||||||:.||.|.|.
Mouse    21 ANHDG---DFGITLTELRALMELRSTDALRKIQESYGDVYGICTKLKTSPNEGLSGNPADLERRE 82

  Fly    66 ETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQE----EEE- 125
            ..||.|.||||.|||||.|||||||||||||||:||:||||||||:|.:.|..:..|    |||
Mouse    83 AVFGKNFIPPKKPKTFLQLVWEALQDVTLIILEIAAIVSLGLSFYQPPEGDNALCGEVSVGEEEG 147

  Fly   126 --HHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILV 188
              ..|||||.|||:||:.||:||||||:|||:||||||:|||.|.||:|||||:|.||.|.||.|
Mouse   148 EGETGWIEGAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRGGQVIQIPVADITV 212

  Fly   189 GDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTA 253
            ||||||||||||||||.|||.||||:||||||||||||||..|.||::|||||||||||:|||||
Mouse   213 GDIAQVKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDPLLLSGTHVMEGSGRMVVTA 277

  Fly   254 VGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTS 318
            ||||||.|||||||||..:|:|   ||.:|:.::.||:::...||..:::.:...|      :..
Mouse   278 VGVNSQTGIIFTLLGAGGEEEE---KKDEKKKEKKNKKQDGAIENRNKAKAQDGAA------MEM 333

  Fly   319 EITKSESEGN---------HLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVI 374
            :..|||..|:         :||            ||||||||.||||||:|||.||..::.:|||
Mouse   334 QPLKSEEGGDGDEKDKKKANLP------------KKEKSVLQGKLTKLAVQIGKAGLLMSAITVI 386

  Fly   375 ILIIQFCIKTFVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMM 435
            ||::.|.|.||.:.::||    ...|....||..||||||||||||||||||||:||||||||||
Mouse   387 ILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMM 451

  Fly   436 KDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITM 500
            ||||||||||||||||||||||||||||||.|||||||:||.||..|.:|....||.::.:.:..
Mouse   452 KDNNLVRHLDACETMGNATAICSDKTGTLTMNRMTVVQAYINEKHYKKVPEPEAIPPNILSYLVT 516

  Fly   501 GISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSV 565
            |||||.||||.|:.....|.||..||||||||||||:..|...||.:|:||.|:...:|||||||
Mouse   517 GISVNCAYTSKILPPEKEGGLPRHVGNKTECALLGFLLDLKRDYQDVRNEIPEEALYKVYTFNSV 581

  Fly   566 RKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLR 630
            ||||.||:...:|.:|:::|||||||:|||..|....|..:.|....::.:::.||||||.:|||
Mouse   582 RKSMSTVLKNSDGSFRIFSKGASEIILKKCFKILSANGEAKVFRPRDRDDIVKTVIEPMASEGLR 646

  Fly   631 TISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGI 695
            ||.:|:|||..|         :.||.||:|.:::|.|||:.|||||||||||||:||:|||||||
Mouse   647 TICLAFRDFPAG---------EPEPEWDNENDVVTGLTCIAVVGIEDPVRPEVPEAIKKCQRAGI 702

  Fly   696 TVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLAR 760
            ||||||||||||||:||:|||||.|.:|||.||||:||||||:..|:|:|..|||:|||||||||
Mouse   703 TVRMVTGDNINTARAIATKCGILHPGEDFLCLEGKDFNRRIRNEKGEIEQERIDKIWPKLRVLAR 767

  Fly   761 SSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTD 825
            ||||||:|||||||||||||.|:||||||||||||||||||||||||||||||||||||||||||
Mouse   768 SSPTDKHTLVKGIIDSTVSEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTD 832

  Fly   826 DNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTL 890
            |||:||||||||||||||||:||||||||||||||||||.|||..||||||||||||||||||||
Mouse   833 DNFTSIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTL 897

  Fly   891 ASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQ 955
            ||||||||.||..|||||||||.||||||||||||||.|.|||:::|.|||.|:...||:|||..
Mouse   898 ASLALATEPPTESLLLRKPYGRNKPLISRTMMKNILGHAFYQLVVVFTLLFAGEKFFDIDSGRNA 962

  Fly   956 ELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYG 1020
            .|:|.|::|:||:|||||:|.||||||||||||:|||.||:..|.||.||.:.|.:.|::|:|:|
Mouse   963 PLHAPPSEHYTIVFNTFVLMQLFNEINARKIHGERNVFEGIFNNAIFCTIVLGTFVVQIIIVQFG 1027

  Fly  1021 KMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFD 1085
            ...||...|:::||||.||.|:|||:|||||:::||.:|..:...|.|..:|......|.|: .:
Mouse  1028 GKPFSCSELSIEQWLWSIFLGMGTLLWGQLISTIPTSRLKFLKEAGHGTQKEEIPEEELAED-VE 1091

  Fly  1086 SID-SDKKPRAGQILWIRGLTRLQTQ-----------------------------LRVIRAFRST 1120
            .|| ::::.|.|||||.|||.|:|||                             :||:.||||:
Mouse  1092 EIDHAERELRRGQILWFRGLNRIQTQMDVVNAFQSGSSIQGALRRQPSIASQHHDIRVVNAFRSS 1156

  Fly  1121 L-EDLNERRSMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSS 1184
            | |.|.:..|..|:|:..:            ||.:..           :..||.:|
Mouse  1157 LYEGLEKPESRSSIHNFMT------------HPEFRI-----------EDSEPHIP--------- 1189

  Fly  1185 GMMSPDISYIDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQSFSKIAQTLQQKIRGN 1241
              :..|....|:.|           |.:.||.|   ||.|::.:.:...:...|..|
Mouse  1190 --LIDDTDAEDDAP-----------TKRNSSPP---PSPNKNNNAVDSGIHLTIEMN 1230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	699/1075 (65%)
		Cation_ATPase_N	36..104	CDD:279080	46/68 (68%)
		E1-E2_ATPase	172..448	CDD:278548	173/288 (60%)
		Cation_ATPase	505..598	CDD:289987	53/92 (58%)
		HAD_like	676..807	CDD:119389	110/130 (85%)
		Cation_ATPase_C	873..1051	CDD:279079	120/177 (68%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	24/75 (32%)
Atp2b1	NP_001346435.1	ATPase-IIB_Ca	15..1064	CDD:273668	699/1075 (65%)
Atp2b1	NP_001346435.1	ATP_Ca_trans_C	1103..1178	CDD:372101	25/86 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I2017
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1379	1.000	Inparanoid score	I125
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	1	1.010	-	-		D115892at2759
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm42499
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R99
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870