DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and atp1a1a.2

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_571762.1	Gene:	atp1a1a.2 / 64613	ZFINID:	ZDB-GENE-001212-2	Length:	1023	Species:	Danio rerio

Alignment Length:	1164	Identity:	303/1164 - (26%)
Similarity:	470/1164 - (40%)	Gaps:	361/1164 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK 79
            ||:..||.:|       |:.    :.||.:|..|...:|||..:|.|...|:  |.|.:.| ||.
Zfish    35 LKKEVELDDH-------KLT----LDELSRKYGTGMIKGLSSFRAKEILERD--GPNALTP-PPT 85

  Fly    80 T-------------FLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIE 131
            |             |.||:|..           |.|..|.......:.|||       .|.....
Zfish    86 TPQWVKFCKLLFGGFQTLLWFG-----------AFLCFLAYGIQVASVEDA-------AHDNLYL 132

  Fly   132 GLAILISVIVVVIVTAFNDYSKER------QFRGL--QNRIEGEHKFSVIRGGEVCQISVGDILV 188
            ||.:   ..||::...|:.|.:.:      .||.|  |..:       |:|.||...|:..:::|
Zfish   133 GLVL---AFVVIVNGWFSFYQESKSSKIMESFRNLVPQQAL-------VVRDGEKKVINAEEVVV 187

  Fly   189 GDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEG 245
            ||:.:|..||.:|||..::.:...|||.|||||||:...:.|:.   :|:     ....|:.:||
Zfish   188 GDLIEVCGGDRIPADLRIVYAQGCKVDNSSLTGESEPQSRSPEFSHENPLETKNIAFFSTNCVEG 252

  Fly   246 SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAP 310
            :.:.:..:.|..:..|.|.:|                                  .|.::|.|.|
Zfish   253 TARGIAISTGDRTIMGRIASL----------------------------------ASSLEGGQTP 283

  Fly   311 SQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVII 375
            ..||.            .|.....|                      |:.| :.|.|..||::|:
Zfish   284 IAREI------------EHFIHIIS----------------------AVSI-FLGVTFFVLSLIL 313

  Fly   376 LIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNL 440
                               .||  .::.::..:.::|..||||||..||:.|..:.|:|.|.|.|
Zfish   314 -------------------GYA--WIEAVVFLIGIIVANVPEGLPATVTVCLTLTAKRMAKKNCL 357

  Fly   441 VRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKV--------------LPTLSDIP 491
            |::|:|.||:|:.|.||||||||||.|||||...:...::.:.              .||.:.:.
Zfish   358 VKNLEAVETLGSTTTICSDKTGTLTQNRMTVAHMWFDSQIHEADTTENQSGTSFDRSSPTWAALA 422

  Fly   492 QHVGNLITMGISVNSAYTSNIMAGHNPGDLPI----QVGNKTECALL-------GFVQGLGVKYQ 545
            :      ..|:...:.:.:      ....||:    ..|:.:|.|||       |.|..:..||:
Zfish   423 R------VAGLCNRAVFRA------EQSHLPVLNRETAGDASESALLKCIELCCGSVIEMREKYR 475

  Fly   546 SIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGG---YRLYTKGASEIIMKKCA--FIYGHEGTL 605
            .|.:          ..|||..|...:|...|:..   :.|..|||.|.|:.:|:  .|.|.|..:
Zfish   476 KICE----------IPFNSTNKYQLSVHKNPSSSGTKHLLVMKGAPERILDRCSTILINGKEQPM 530

  Fly   606 EKFTRD-----------MQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDD 659
            :...:|           :.||::          |....::....|..|.|            :|.
Zfish   531 DDENKDSFQSAYVELGGLGERVL----------GFCQYNLPDDQFPEGFA------------FDP 573

  Fly   660 EE-NIMT-NLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPND 722
            |: |..| ||..|.::.:.||.|..||||:.||:.|||.|.|||||:..||::||...||:...:
Zfish   574 EDVNFPTENLCFLGLMSMIDPPRAAVPDAVAKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGN 638

  Fly   723 DFL----------------------ILEGKEFNRRIRDSNGDIQQHLIDKVWPKLR-----VLAR 760
            :.:                      ::.|.|. :.:.||:       :|::   ||     |.||
Zfish   639 ETVEDIAARMNIPVGEVNPREAKACVVHGGEL-KNMNDSD-------LDEI---LRYHTEIVFAR 692

  Fly   761 SSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTD 825
            :||..|..:|:|     ......:|||||||.||.|||||||:|.||||:|:||:|:|:|:||.|
Zfish   693 TSPQQKLIIVEG-----CQRQGAIVAVTGDGVNDSPALKKADIGVAMGISGSDVSKQAADMILLD 752

  Fly   826 DNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNV-------VAVIVAFIGACAVQDSPLKAVQMLWV 883
            |||:|||..|..||.::|::.|.:.:.||..:       :.|:|..       ..||..|.:|::
Zfish   753 DNFASIVTGVEEGRLIFDNLKKSIAYTLTSKIPEMSPFLMFVVVGI-------PLPLGTVTILFI 810

  Fly   884 NLIMDTLASLALATEFPTPDLLLRKPYGRTKP-LISRTMMKNILGQ-ALYQLIIIF--------- 937
            :|..|.:.:::.|.|....|::.|:|....|. |::..::....|| .:.|.:..|
Zfish   811 DLGTDLIPAISYAYENAENDIMKRQPRNAQKDRLVNERLISMAYGQIGMIQAVAGFFTYITVMAE 875

  Fly   938 -GL-------LFVG---DVILDIESGRGQELN------AGPTQHFTIIFNTFV------MMTLFN 979
             |.       |.||   ..|.|:|...||:..      ...|.| |..|.:.|      ::.:..
Zfish   876 NGFRPSYLPGLRVGWEDRSIGDLEDSYGQQWTYEGRKIIESTCH-TAFFISIVVVQWADLLIVKT 939

  Fly   980 EINARKIHGQRNVI-------EGLLTNPIFY--------------TIWIFTMISQVLII 1017
            ..|:....|.:|.:       ||.|...:.|              .:|.||.:...|||
Zfish   940 RRNSILQQGMKNKVLIFAFFEEGALAAFLSYCPGMDIAVRMYPLRPLWWFTALPYALII 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	303/1164 (26%)
		Cation_ATPase_N	36..104	CDD:279080	22/80 (28%)
		E1-E2_ATPase	172..448	CDD:278548	68/283 (24%)
		Cation_ATPase	505..598	CDD:289987	25/108 (23%)
		HAD_like	676..807	CDD:119389	56/157 (36%)
		Cation_ATPase_C	873..1051	CDD:279079	44/200 (22%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
atp1a1a.2	NP_571762.1	ATPase-IIC_X-K	31..1023	CDD:273445	303/1164 (26%)
		Cation_ATPase_N	40..114	CDD:214842	26/98 (27%)
		E1-E2_ATPase	134..365	CDD:278548	77/330 (23%)
		Cation_ATPase	427..521	CDD:289987	25/109 (23%)
		COG4087	<677..752	CDD:226572	40/89 (45%)
		Cation_ATPase_C	799..1008	CDD:279079	44/201 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010