Protein Alignment PMCA and JYalpha

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_001104092.2
• Gene: JYalpha / 5740846
• FlyBaseID: FBgn0267363
• Length: 1009
• Species: Drosophila melanogaster
• Alignment Length: 1137
• Identity: 296/1137 - (26%)
• Similarity: 475/1137 - (41%)
• Gaps: 316/1137 - (27%)

  Fly    39 IHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPP--------KT----FLTLVWEALQD 91
            :.||.::|.|.||.|||..:|  :.|.|..|.|::.|:||        ||    |..|:|..
  Fly    37 VDELLERLKTDPNMGLSFVEA--KLRLEINGPNILTPQPPTPKWIVFLKTMFGGFAILLWAG--- 96

  Fly    92 VTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQ 156
              ..:..|..|:.|... ::|.|::..:            |:|:.:.|||..:.|.|..:.....
  Fly    97 --SFLCFVGYLIQLQTQ-HEPPDDNLYL------------GIALTVLVIVTGLFTYFQVHKSSSI 146

  Fly   157 FRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTG 221
            ....:|.:  ....:|||.||:..::..:|:.|||.:||:||.:|||..:::::.||||.|||||
  Fly   147 MDSFKNLV--PQYATVIREGEINTVTSDEIVKGDIVEVKFGDRVPADIRILEAHGLKVDNSSLTG 209

  Fly   222 ES-------DHVKKGP-DVDPMVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEI 278
            ||       :...:.| :...:....|:|:||:.:.||.|.|.::..|.|.. |.|.:|:
  Fly   210 ESEPQVRSTEFTHENPLETKNLAFFSTNVLEGTCRGVVIATGDSTVMGRIAN-LAAGLDD----- 268

  Fly   279 KKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGH 343
                                        .|:|..||
  Fly   269 ----------------------------VQSPISRE----------------------------- 276

  Fly   344 KKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGV 408
                       .:|.|:.      |.:..:|:.:..|.|..          |.....:..::..:
  Fly   277 -----------IQLFIRF------ITIFAIILGLSFFAISL----------TLGYEFIDAVVFLI 314

  Fly   409 TVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTV-- 471
            .::|..|||||.:.||:.|..:.|:|...|.||::|:|.||:|:.:.||||||||||.|||||
  Fly   315 GIIVANVPEGLLVTVTVCLTLTAKRMASKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAH 379

  Fly   472 -------VQS---------------------YICEKLCKVLPTLSDIPQHVGNLITMGISVNSAY 508
                   |:|                     ::|..||                       |||
  Fly   380 LWYDQIIVESDTTESFRGSHFKIEDKSFNALFMCAALC-----------------------NSA- 420

  Fly   509 TSNIMAGHNPGDLPI----QVGNKTECALLGFVQ----GLG------VKYQSIRDEITEDKFTRV 559
              ....|.:  |:|:    ..||.:|.|||.|.:    |:|      :|...|....||.....|
  Fly   421 --EFKGGQD--DIPVFKKDVNGNASEAALLKFTETIFAGIGAFRQKHIKLTEIPFNSTEKYQVSV 481

  Fly   560 YTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPM 624
            :.|||           .:|.:.:..|||.|.|:.:|:.|. .:|...:.|..::.......:| |
  Fly   482 HEFNS-----------SDGYFIVEMKGAPERILDRCSTII-IQGLSVELTPTLKLEFEEAYLE-M 533

  Fly   625 ACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRK 689
            ...|.|.:..|.......|..|:.......||:.     :.||..|.::.:.||.|..||||:.|
  Fly   534 GGMGERVLGFADLLLPMSKYPISYEFSADPPNFP-----LENLRFLGLISLIDPPRAAVPDAVAK 593

  Fly   690 CQRAGITVRMVTGDNINTARSIASKCGIL-RPN-DDF------------------LILEGKEFNR 734
            |:.||:.|.|||||:..||::||...||: .|. :|.                  :::.|.|. |
  Fly   594 CRSAGVRVIMVTGDHPITAKAIARSVGIITTPTAEDIAKQRGVTVLDIDSRQATAIVVHGGEL-R 657

  Fly   735 RIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALK 799
            .::....|...:..:::     |.||:||..|..:|:     ......|:|||||||.||.||||
  Fly   658 EMKAEELDAVIYYHNEI-----VFARTSPQQKLIIVE-----ACQRRGEIVAVTGDGVNDSPALK 712

  Fly   800 KADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVI--V 862
            :||:|.||||:|:||:|:|:|:||.||||:|||..:..||.::|::.|.:.:.||.|:..::  :
  Fly   713 RADIGVAMGISGSDVSKQAADMILLDDNFASIVVGIEEGRIIFDNLKKSIAYTLTSNLPEIVPFL 777

  Fly   863 AFIGACAVQDSPLK--AVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISRTMMKNI 925
            .|:    :.|.||.  .:.:|.:::..|.|.:::||.|....|::.|.|   ..|...|.:.|.:
  Fly   778 FFV----IFDIPLALGTIAILCIDIGTDMLPAISLAYEKAESDIMARMP---RDPFEDRLVNKKL 835

  Fly   926 LGQALYQLIII---------FGLL----------------FVGDVILDIESGRGQ---------- 955
            :..|..|:.:|         |.::                :....:.|:|.|.||
  Fly   836 ILMAYLQIGVIQTVACFFTFFAIMAEHGFPPSRLKGIREDWDSKNVEDLEDGYGQEWTYRERKVL 900

  Fly   956 ELNAGPTQHF-----TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVL 1015
            |..|| |..|     |.:|:..:..|..|.|.      |:.:...:|...:.....|..::..|.
  Fly   901 EYTAG-TGFFVSIVVTQVFDLLICKTRRNSIL------QQGMGNHVLNFALVLEFIIACLLCYVP 958

  Fly  1016 IIQYGKMAFSTKALTLDQWLWCIFFGIGTLVW 1047
            :.:.....:|.|.:    | |...|..|.|::
  Fly   959 VFEKTLRMYSIKFI----W-WIYAFPFGLLIF 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	296/1137 (26%)
		Cation_ATPase_N	36..104	CDD:279080	24/76 (32%)
		E1-E2_ATPase	172..448	CDD:278548	68/283 (24%)
		Cation_ATPase	505..598	CDD:289987	30/106 (28%)
		HAD_like	676..807	CDD:119389	53/150 (35%)
		Cation_ATPase_C	873..1051	CDD:279079	44/217 (20%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
JYalpha	NP_001104092.2	ATPase-IIC_X-K	17..1009	CDD:273445	296/1137 (26%)
		Cation_ATPase_N	29..102	CDD:214842	22/71 (31%)
		E1-E2_ATPase	123..354	CDD:278548	75/322 (23%)
		Cation_ATPase	416..509	CDD:289987	32/131 (24%)
		COG4087	<673..738	CDD:226572	36/74 (49%)
		Cation_ATPase_C	785..994	CDD:279079	44/216 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438597
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840