back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ATP4A

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_000695.2	Gene:	ATP4A / 495	HGNCID:	819	Length:	1035	Species:	Homo sapiens

Alignment Length:	1174	Identity:	306/1174 - (26%)
Similarity:	489/1174 - (41%)	Gaps:	327/1174 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 RELMEHRGREGVMKIAENG-GIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK--- 79
            :|.:|:..:|  |:|.::. .:.||.:|..||..:|||.|.|.|...|:  |.|.:  :||:
Human    40 KEKLENMKKE--MEINDHQLSVAELEQKYQTSATKGLSASLAAELLLRD--GPNAL--RPPRGTP 98

  Fly    80 ---TFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIEGLAILISVIV 141
               .|...:...||    .::.|||.:.| ::|         .:|..|......:.|.:.|::|.
Human    99 EYVKFARQLAGGLQ----CLMWVAAAICL-IAF---------AIQASEGDLTTDDNLYLAIALIA 149

  Fly   142 VVIVTA----FNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKYGDLLPA 202
            ||:||.    :.::.........:|.:  ..:.:|||.|:..||:...::|||:.::|.||.:||
Human   150 VVVVTGCFGYYQEFKSTNIIASFKNLV--PQQATVIRDGDKFQINADQLVVGDLVEMKGGDRVPA 212

  Fly   203 DGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGSGKMVVTAVGVNSQ 259
            |..::.:...|||.|||||||:...:.|:.   .|:     ....|..:||
Human   213 DIRILAAQGCKVDNSSLTGESEPQTRSPECTHESPLETRNIAFFSTMCLEG-------------- 263

  Fly   260 AGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSE 324
                 |:.|..|:                      ||:                .|:...|....
Human   264 -----TVQGLVVN----------------------TGD----------------RTIIGRIASLA 285

  Fly   325 SEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVI----ILIIQFCI-KT 384
            |                |.:.||       |.:||:|.:....||.|.::    ..|:..|| .|
Human   286 S----------------GVENEK-------TPIAIEIEHFVDIIAGLAILFGATFFIVAMCIGYT 327

  Fly   385 FVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACET 449
            |               ::.::..:.::|..|||||...||:.|:.:.|::...|.:|::|:|.||
Human   328 F---------------LRAMVFFMAIVVAYVPEGLLATVTVCLSLTAKRLASKNCVVKNLEAVET 377

  Fly   450 MGNATAICSDKTGTLTTNRMTV------------------------VQSYICEKLCKVLPTLSDI 490
            :|:.:.||||||||||.|||||                        ..|.....||:|| ||.:
Human   378 LGSTSVICSDKTGTLTQNRMTVSHLWFDNHIHTADTTEDQSGQTFDQSSETWRALCRVL-TLCN- 440

  Fly   491 PQHVGNLITMGISVNSAYTSNIMAGHNPGDLP--IQVGNKTECALLGFVQ---GLGVKYQSIRDE 550
                          .:|:.|    |.:...:|  |.:|:.:|.|||.|.:   |..:.|:
Human   441 --------------RAAFKS----GQDAVPVPKRIVIGDASETALLKFSELTLGNAMGYR----- 482

  Fly   551 ITEDKFTRV--YTFNSVRK---SMGTVIPRPNGGYRLYTKGASEIIMKKCA--FIYGHEGTLEKF 608
               |:|.:|  ..|||..|   |:.|:....:..:.|..|||.|.::::|:  .|.|.|..|::.
Human   483 ---DRFPKVCEIPFNSTNKFQLSIHTLEDPRDPRHLLVMKGAPERVLERCSSILIKGQELPLDEQ 544

  Fly   609 TRD-----------MQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEEN 662
            .|:           :.||::          |...:.:..:|:.||.|.             |.|.
Human   545 WREAFQTAYLSLGGLGERVL----------GFCQLYLNEKDYPPGYAF-------------DVEA 586

  Fly   663 IMTNLTCLCVVGIE---DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDF 724
            :....:.||..|:.   ||.|..||||:.||:.|||.|.|||||:..||::||:..||
Human   587 MNFPSSGLCFAGLVSMIDPPRATVPDAVLKCRTAGIRVIMVTGDHPITAKAIAASVGI------- 644

  Fly   725 LILEGKE---------------FNRR-----------IRDSNGDIQQHLID--KVWPKLRVLARS 761
             |.||.|               .||:           ::|.:   ...|::  :..|:: |.||:
Human   645 -ISEGSETVEDIAARLRVPVDQVNRKDARACVINGMQLKDMD---PSELVEALRTHPEM-VFART 704

  Fly   762 SPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDD 826
            ||..|..:|:     :......:|||||||.||.|||||||:|.||||||:|.||.|:|:||.||
Human   705 SPQQKLVIVE-----SCQRLGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDAAKNAADMILLDD 764

  Fly   827 NFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLA 891
            ||:|||..|..||.::|::.|.:.:.||.|:..:....|........||..:.:|::.|..|...
Human   765 NFASIVTGVEQGRLIFDNLKKSIAYTLTKNIPELTPYLIYITVSVPLPLGCITILFIELCTDIFP 829

  Fly   892 SLALATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIII------------------FG 938
            |::||.|....|::..:|   ..|...|.:.:.:...:.:|:..|                  |.
Human   830 SVSLAYEKAESDIMHLRP---RNPKRDRLVNEPLAAYSYFQIGAIQSFAGFTDYFTAMAQEGWFP 891

  Fly   939 LLFVG-------DVILDIESGRGQELNAGPT--QHFT--IIFNTFVMMTLFNEINARKIHGQRNV 992
            ||.||       ..:.|::...|||...|..  |.:|  .:|...:.:....::..||.......
Human   892 LLCVGLRAQWEDHHLQDLQDSYGQEWTFGQRLYQQYTCYTVFFISIEVCQIADVLIRKTRRLSAF 956

  Fly   993 IEGLLTNPIFYTIWIFTMISQVLIIQYGKM--AFSTKALTLDQWLWCIFFGIGTLVWGQLITSVP 1055
            .:|...|.|.....:|.:.....:.....|  .|:...:....||..:.:||...|:.::
Human   957 QQGFFRNKILVIAIVFQVCIGCFLCYCPGMPNIFNFMPIRFQWWLVPLPYGILIFVYDEI----- 1016

  Fly  1056 TRKL 1059
             |||
Human  1017 -RKL 1019

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.