DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and SERCA

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_726381.1	Gene:	SERCA / 49297	FlyBaseID:	FBgn0263006	Length:	1020	Species:	Drosophila melanogaster

Alignment Length:	1105	Identity:	293/1105 - (26%)
Similarity:	478/1105 - (43%)	Gaps:	224/1105 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 TSPNEGLSGSKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKP 112
            |.|..||:..:.....::  :|.|.:|.:..|:...||.|...|:.:.||.:||::|..|:.::
  Fly    18 TDPERGLTLDQIKANQKK--YGPNELPTEEGKSIWQLVLEQFDDLLVKILLLAAIISFVLALFE- 79

  Fly   113 ADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGE 177
                    :.||....::|.|.||:.:|...:|..:       |.|..::.||...::....|..
  Fly    80 --------EHEETFTAFVEPLVILLILIANAVVGVW-------QERNAESAIEALKEYEPEMGKV 129

  Fly   178 VCQISVG-------DILVGDIAQVKYGDLLPADGCL--IQSNDLKVDESSLTGESDHVKKGPDVD 233
            |.|...|       :|:.||:.:|..||.:|||..:  |.|..|::|:|.|||||..|.|..|..
  Fly   130 VRQDKSGIQKVRAKEIVPGDLVEVSVGDKIPADIRITHIYSTTLRIDQSILTGESVSVIKHTDAI 194

  Fly   234 P-----------MVLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKR 287
            |           ::.|||:|..|..:.||...|:::..|                  |::.|...
  Fly   195 PDPRAVNQDKKNILFSGTNVAAGKARGVVIGTGLSTAIG------------------KIRTEMSE 241

  Fly   288 ANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQA 352
                                         |.||                          |:.||.
  Fly   242 -----------------------------TEEI--------------------------KTPLQQ 251

  Fly   353 KLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPE 417
            ||.:...|:....|.|.|....|.|..|       ::.....::....:.:..|.|.:.|.|:||
  Fly   252 KLDEFGEQLSKVISVICVAVWAINIGHF-------NDPAHGGSWIKGAIYYFKIAVALAVAAIPE 309

  Fly   418 GLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKL-- 480
            |||..:|..||...::|.|.|.:||.|.:.||:|..:.||||||||||||:|:|.:.:|.:|:
  Fly   310 GLPAVITTCLALGTRRMAKKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVSRMFIFDKVEG 374

  Fly   481 ----CKVLPTLSDIPQHVGNLITMGISVNSA--------YTSNIMAGHNPGDLP------IQVGN 527
                ...........:.:|.:...|..:.:|        .|..||...:..|..      .:||.
  Fly   375 NDSSFLEFEMTGSTYEPIGEVFLNGQRIKAADYDTLQELSTICIMCNDSAIDYNEFKQAFEKVGE 439

  Fly   528 KTECALLGFVQGL--------GVKYQS----IRDEITEDKFTRVYT--FNSVRKSMGTV-----I 573
            .||.||:...:.|        |:..:|    .|.|| |.|:.:.:|  |:..||||.:.     .
  Fly   440 ATETALIVLAEKLNSFSVNKSGLDRRSAAIACRGEI-ETKWKKEFTLEFSRDRKSMSSYCTPLKA 503

  Fly   574 PRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLE-KFTRDMQERLIREVIE-PMACDGLRTISVAY 636
            .|...|.:|:.|||.|.::::|.  :...||.: ..|..::.:::....: ....|.||.:::|.
  Fly   504 SRLGTGPKLFVKGAPEGVLERCT--HARVGTTKVPLTSALKAKILALTGQYGTGRDTLRCLALAV 566

  Fly   637 RDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVT 701
            .| .|.|.  :|:.:.....:...|   .|||.:.|||:.||.|.||.|:|.:|:.|||.|.::|
  Fly   567 AD-SPMKP--DEMDLGDSTKFYQYE---VNLTFVGVVGMLDPPRKEVFDSIVRCRAAGIRVIVIT 625

  Fly   702 GDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDK 766
            |||..||.:|..:.|:...::|   ..||.::.|..|.....:|   .....:.|:.:|..|..|
  Fly   626 GDNKATAEAICRRIGVFAEDED---TTGKSYSGREFDDLSPTEQ---KAAVARSRLFSRVEPQHK 684

  Fly   767 YTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSI 831
            ..:|:     .:....|:.|:||||.||.||||||::|.||| :||.|||.|::::|.|||||||
  Fly   685 SKIVE-----FLQSMNEISAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLADDNFSSI 743

  Fly   832 VKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALA 896
            |.||..||.:|:::.:|:::.::.|:..|:..|:.|.......|..||:|||||:.|.|.:.||.
  Fly   744 VSAVEEGRAIYNNMKQFIRYLISSNIGEVVSIFLTAALGLPEALIPVQLLWVNLVTDGLPATALG 808

  Fly   897 TEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDV----ILDIES------ 951
            ...|..|::.:.|....:.|||..:....:....|     .|...||..    :...|.
  Fly   809 FNPPDLDIMEKPPRKADEGLISGWLFFRYMAIGFY-----VGAATVGAAAWWFVFSDEGPKLSYW 868

  Fly   952 ---------GRGQELNAGPTQHF------TIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPI 1001
                     |.|.|......:.|      |:..:..|.:.:.|.:|:...:      :.|:|.|.
  Fly   869 QLTHHLSCLGGGDEFKGVDCKIFSDPHAMTMALSVLVTIEMLNAMNSLSEN------QSLITMPP 927

  Fly  1002 FYTIWI-------FTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKL 1059
            :..:|:       ||:...:|.:......|....|:.::|:..:.|.|..::..:.:..| .||:
  Fly   928 WCNLWLIGSMALSFTLHFVILYVDVLSTVFQVTPLSAEEWITVMKFSIPVVLLDETLKFV-ARKI 991

Fly 1060 1059
Fly 992 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	291/1101 (26%)
		Cation_ATPase_N	36..104	CDD:279080	16/55 (29%)
		E1-E2_ATPase	172..448	CDD:278548	71/295 (24%)
		Cation_ATPase	505..598	CDD:289987	33/125 (26%)
		HAD_like	676..807	CDD:119389	46/130 (35%)
		Cation_ATPase_C	873..1051	CDD:279079	43/209 (21%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
SERCA	NP_726381.1	P-type_ATPase_SERCA	5..989	CDD:319778	291/1101 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438613
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840