Protein Alignment PMCA and ATP2B3

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_016885042.1
• Gene: ATP2B3 / 492
• HGNCID: 816
• Length: 1274
• Species: Homo sapiens
• Alignment Length: 1128
• Identity: 721/1128 - (63%)
• Similarity: 855/1128 - (75%)
• Gaps: 56/1128 - (4%)

  Fly    11 YGISLKQLRELMEHRGREGVMKIAE-NGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            :|.:|.:||.|||.||.|.:.||.| .|.:..||::|.|||.|||:.:..|.|.||:.:|.|.||
Human    27 FGCTLAELRTLMELRGAEALQKIEEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIP 91

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEEHHGWIE 131
            ||.|||||.||||||||||||||||||:||||||||.|..|::...        .|.|...||||
Human    92 PKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIE 156

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:|||.||:||||||:|||:||||||:|||.|.||:|||.|::.|:.|..::|||||||||
Human   157 GAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY 221

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||:||||:||||||||||||:|..|.|||:|||||||||||:|||||||||||.|
Human   222 GDLLPADGVLIQANDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTG 286

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDG---RSQIKGSQ---------APSQRE 314
            ||||||||..:|:|.:.||.|::              ||   .||.||:.         |..|..
Human   287 IIFTLLGAGGEEEEKKDKKGKQQ--------------DGAMESSQTKGTDLGHGVPLCAAKKQDG 337

  Fly   315 TVTSEITKSES-EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILII 378
            .|..|:...:| ||..:.:.....|  ...||||||||.||||||:|||.||..::.:|||||::
Human   338 AVAMEMQPLKSAEGGEMEEREKKKA--NAPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVL 400

  Fly   379 QFCIKTFVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNN 439
            .|.|:|||::.:.|    ...|....||..||||||||||||||||||||:||||||||||||||
Human   401 YFVIETFVVEGRTWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNN 465

  Fly   440 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISV 504
            ||||||||||||||||||||||||||||||||||||:.:...|.:|..|.:...:.:|:...||:
Human   466 LVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISI 530

  Fly   505 NSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSM 569
            |||||:.|:.....|.||.||||||||||||||..|...:|.:|::|.|||..:|||||||||||
Human   531 NSAYTTKILPPEKEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDKLYKVYTFNSVRKSM 595

  Fly   570 GTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISV 634
            .|||..|:||:||::||||||::|||..|....|.|..|....::.::|::||||||||||||.:
Human   596 STVIRMPDGGFRLFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVRKIIEPMACDGLRTICI 660

  Fly   635 AYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRM 699
            |||||..|:          ||:||:|..::.:|||:.|||||||||||||:||||||||||||||
Human   661 AYRDFSAGQ----------EPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRM 715

  Fly   700 VTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPT 764
            ||||||||||:||:||||::|.:|||.|||||||||||:..|:|:|..:||||||||||||||||
Human   716 VTGDNINTARAIAAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPT 780

  Fly   765 DKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFS 829
            ||:||||||||||..|.|:|||||||||||||||||||||||||||||||||||||||||||||:
Human   781 DKHTLVKGIIDSTTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFT 845

  Fly   830 SIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLA 894
            ||||||||||||||||:||||||||||||||||||.|||..|||||||||||||||||||.||||
Human   846 SIVKAVMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLA 910

  Fly   895 LATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNA 959
            ||||.||..|||||||||.||||||||||||||.|:|||.|||.|||||::..||:|||...|::
Human   911 LATEPPTESLLLRKPYGRDKPLISRTMMKNILGHAVYQLAIIFTLLFVGELFFDIDSGRNAPLHS 975

  Fly   960 GPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAF 1024
            .|::|:||||||||||.||||||||||||:|||.:|:.:||||.||.:.|...|::|:|:|...|
Human   976 PPSEHYTIIFNTFVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPF 1040

  Fly  1025 STKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRG-HPEEYTD-GMNLGEERFDSI 1087
            |...|:.:|||||:|.|:|.|||||:|.::||.:|..:...|.| ..:|.|| .:..|||..|
Human  1041 SCSPLSTEQWLWCLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEID-- 1103

  Fly  1088 DSDKKPRAGQILWIRGLTRLQTQ 1110
            .::::.|.|||||.|||.|:|||
Human  1104 HAERELRRGQILWFRGLNRIQTQ 1126

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	590/883 (67%)
		Cation_ATPase_C	873..1051	CDD:376368	123/177 (69%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	12/15 (80%)
ATP2B3	XP_016885042.1	ATPase-IIB_Ca	27..1073	CDD:273668	697/1071 (65%)
		ATP_Ca_trans_C	1112..>1126	CDD:463575	10/13 (77%)