DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PMCA and ATP2A3

DIOPT Version :9

Sequence 1:NP_001014689.3 Gene:PMCA / 43787 FlyBaseID:FBgn0259214 Length:1255 Species:Drosophila melanogaster
Sequence 2:XP_011522183.1 Gene:ATP2A3 / 489 HGNCID:813 Length:1114 Species:Homo sapiens


Alignment Length:1221 Identity:317/1221 - (25%)
Similarity:502/1221 - (41%) Gaps:310/1221 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 SKADEEHRRETFGSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQ 121
            |.|.....||.:|.|.:|.:..|:...||.|..:|:.:.||.:|||||..|::::         :
Human    25 SPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFE---------E 80

  Fly   122 EEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKF-SVIRGGE--VCQISV 183
            .||....::|.|.|::.::...||..:.:.:.|.....|:   |.|.:. .|||...  |.:|..
Human    81 GEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALK---EYEPEMGKVIRSDRKGVQRIRA 142

  Fly   184 GDILVGDIAQVKYGDLLPADGCLIQ--SNDLKVDESSLTGESDHVKKGPDVDP-----------M 235
            .||:.|||.:|..||.:|||..||:  |..|:||:|.|||||..|.|..:..|           |
Human   143 RDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNM 207

  Fly   236 VLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDG 300
            :.|||::..|....|..|.|::::.|.|                                     
Human   208 LFSGTNITSGKAVGVAVATGLHTELGKI------------------------------------- 235

  Fly   301 RSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAG 365
            |||:                                .|.|    .|::.||.||.:...|:.:|.
Human   236 RSQM--------------------------------AAVE----PERTPLQRKLDEFGRQLSHAI 264

  Fly   366 STIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYS 430
            |.|.|...:|.|..|.       :.....::....|.:..|.|.:.|.|:|||||..:|..||..
Human   265 SVICVAVWVINIGHFA-------DPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALG 322

  Fly   431 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVG 495
            .::|.:.|.:||.|.:.||:|..:.||||||||||||:|:|.:.::..:            ...|
Human   323 TRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAE------------ADAG 375

  Fly   496 NLITMGISVN-SAYTSNIMAGH-NPGDLPIQVGN-------KTECAL-----LGFVQGLGVKYQS 546
            :.:....::: :.||..   |. ..||.|::.|.       .|.|||     |.:.:..|| |:.
Human   376 SCLLHEFTISGTTYTPE---GEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGV-YEK 436

  Fly   547 IRDEITEDKFT----------------------------------RVYT--FNSVRKSMGTVI-- 573
            : .|.||...|                                  :.:|  |:..||||....  
Human   437 V-GEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTP 500

  Fly   574 --PRPNG-GYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIE-PMACDGLRTISV 634
              |.|.| |.:::.|||.|.::::|:.:.....| ...|...:|:::.::.: ....|.||.:::
Human   501 TRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRT-APLTPTSREQILAKIRDWGSGSDTLRCLAL 564

  Fly   635 AYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRM 699
            |.||..|.|   .::.:|....:...|   |:||.:..||:.||.||||...|.:|.:|||.|.|
Human   565 ATRDAPPRK---EDMELDDCSKFVQYE---TDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVM 623

  Fly   700 VTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPT 764
            :||||..||.:|..:.||....:|   :.||.:..|..|.....||.   :.....|..||..|.
Human   624 ITGDNKGTAVAICRRLGIFGDTED---VAGKAYTGREFDDLSPEQQR---QACRTARCFARVEPA 682

  Fly   765 DKYTLVKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFS 829
            .|..:|:.:     ....|:.|:||||.||.||||||::|.||| :||.|||.|::::|:||||:
Human   683 HKSRIVENL-----QSFNEITAMTGDGVNDAPALKKAEIGIAMG-SGTAVAKSAAEMVLSDDNFA 741

  Fly   830 SIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLA 894
            |||.||..||.:|.::.:|:::.::.||..|:..|:.|.......|..||:|||||:.|.|.:.|
Human   742 SIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATA 806

  Fly   895 LATEFPTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDV----ILDIESGRGQ 955
            |....|..|::.:.|....:.|||..:....|...:|     .||..|...    :.|.|   |.
Human   807 LGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVY-----VGLATVAAATWWFVYDAE---GP 863

  Fly   956 ELNAGPTQHF------------------------TIIFNTFVMMTLFNEINARKIHGQRNVIEGL 996
            .:|....::|                        |:..:..|.:.:.|.:|:...:      :.|
Human   864 HINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSEN------QSL 922

  Fly   997 LTNPIFYTIWIFTMISQ-------VLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLI--- 1051
            |..|.:...|:...::.       :|::....:.|....|:..||:..:...:..::..:.:   
Human   923 LRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYL 987

  Fly  1052 ----------------TSVPTRKLPKILSWGRGHPEEYTDGMNLGEERFDSIDSDKKPRAGQILW 1100
                            .|....:.|...||...|..|       ||..                 
Human   988 SR
NHMHACLYPGLLRTVSQAWSRQPLTTSWTPDHTGE-------GETN----------------- 1028

  Fly  1101 IRGLTRLQTQLRVIRAFRSTLEDL---NERRSMHSLHSLRSPRTGIPVAVG 1148
                         .|.:.|.:|.:   ..|:.:| ||.|.. .|.:||..|
Human  1029 -------------TRRWASGIEQIWGAGPRKHLH-LHLLEM-LTVVPVKFG 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PMCANP_001014689.3 ATPase-IIB_Ca 1..1057 CDD:273668 298/1125 (26%)
Cation_ATPase_N 36..104 CDD:279080 17/46 (37%)
E1-E2_ATPase 172..448 CDD:278548 77/290 (27%)
Cation_ATPase 505..598 CDD:289987 34/147 (23%)
HAD_like 676..807 CDD:119389 50/130 (38%)
Cation_ATPase_C 873..1051 CDD:279079 41/212 (19%)
ATP_Ca_trans_C 1096..1142 CDD:289209 8/48 (17%)
ATP2A3XP_011522183.1 Cation_ATPase_N 4..72 CDD:279080 17/46 (37%)
ATPase-IIA1_Ca 53..989 CDD:273452 288/1077 (27%)
E1-E2_ATPase 92..340 CDD:278548 85/330 (26%)
Cation_ATPase 419..528 CDD:289987 24/110 (22%)
HAD <604..712 CDD:289480 43/118 (36%)
Cation_ATPase_C 784..987 CDD:279079 41/216 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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