DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ATP1A4

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_653300.2	Gene:	ATP1A4 / 480	HGNCID:	14073	Length:	1029	Species:	Homo sapiens

Alignment Length:	1176	Identity:	310/1176 - (26%)
Similarity:	485/1176 - (41%)	Gaps:	302/1176 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 KQLRELMEHRGREGVM---KIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKP 77
            ||.|. ||...:|.||   |:.    :.||..|......:|.|..:|.|...|.  |.|.:.| |
Human    35 KQKRN-MEELKKEVVMDDHKLT----LEELSTKYSVDLTKGHSHQRAKEILTRG--GPNTVTP-P 91

  Fly    78 PKT-------------FLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGW 129
            |.|             |..|:|..         .:...|:..:..|         ..||...
Human    92 PTTPEWVKFCKQLFGGFSLLLWTG---------AILCFVAYSIQIY---------FNEEPTK--- 135

  Fly   130 IEGLAILISVIVVVIVTAFNDYSKERQ----FRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGD 190
             :.|.:.|.:.||||||....|.:|.:    ....:|.:  ..:..||||||..||:|.::::||
Human   136 -DNLYLSIVLSVVVIVTGCFSYYQEAKSSKIMESFKNMV--PQQALVIRGGEKMQINVQEVVLGD 197

  Fly   191 IAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGSG 247
            :.::|.||.:|||..||.:...|||.|||||||:...:.||.   :|:     ....|:.:||:.
Human   198 LVEIKGGDRVPADLRLISAQGCKVDNSSLTGESEPQSRSPDFTHENPLETRNICFFSTNCVEGTA 262

  Fly   248 KMVVTAVGVNSQAGIIFTLL-GAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPS 311
            :.:|.|.|.::..|.|.:|. |.||.:
Human   263 RGIVIATGDSTVMGRIASLTSGLAVGQ-------------------------------------- 289

  Fly   312 QRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIIL 376
                                                       |.:|.:|.:....|.|:.|.:.
Human   290 -------------------------------------------TPIAAEIEHFIHLITVVAVFLG 311

  Fly   377 IIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLV 441
            :..|.:...:          ....::.:|..:.::|..|||||...||:.|..:.|:|.:.|.||
Human   312 VTFFALSLLL----------GYGWLEAIIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLV 366

  Fly   442 RHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNS 506
            ::|:|.||:|:.:.||||||||||.|||||...:....:.:...|    .:..|...|.  |.::
Human   367 KNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDMTVYEADTT----EEQTGKTFTK--SSDT 425

  Fly   507 AYTSNIMAG--------HNPGDLPI----QVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRV 559
            .:....:||        .|...|||    ..|:.:|.|||.|::   ..|.|:.:...::.....
Human   426 WFMLARIAGLCNRADFKANQEILPIAKRATTGDASESALLKFIE---QSYSSVAEMREKNPKVAE 487

  Fly   560 YTFNSVRKSMGTVIPRPNGG--YRLYTKGASEIIMKKCA--FIYGHEGTLEKFTRDMQERLIREV 620
            ..|||..|...::..|.:..  :.|..|||.|.|::.|:  .:.|.|.::..   :|:|......
Human   488 IPFNSTNKYQMSIHLREDSSQTHVLMMKGAPERILEFCSTFLLNGQEYSMND---EMKEAFQNAY 549

  Fly   621 IEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENI-MTNLTCLCVVGIEDPVRPEVP 684
            :| :...|.|.:...:.: :|...:      .|.|...||.|. |.||..:.::.:.||.|..||
Human   550 LE-LGGLGERVLGFCFLN-LPSSFS------KGFPFNTDEINFPMDNLCFVGLISMIDPPRAAVP 606

  Fly   685 DAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDD----------------------FLIL 727
            ||:.||:.|||.|.|||||:..||::||...||:....:                      .:::
Human   607 DAVSKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGTETAEEVAARLKIPISKVDASAAKAIVV 671

  Fly   728 EGKEFNRRIRDSNGDIQQHLIDKV---WPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTG 789
            .|.|..        |||...:|::   .|:: |.||:||..|..:|:|     ......||||||
Human   672 HGAELK--------DIQSKQLDQILQNHPEI-VFARTSPQQKLIIVEG-----CQRLGAVVAVTG 722

  Fly   790 DGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLT 854
            ||.||.|||||||:|.||||:|:||:|:|:|:||.||||:|||..|..||.::|::.|.:.:.||
Human   723 DGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIMYTLT 787

  Fly   855 VNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRKPYGRTKPLISR 919
            .|:..:....:........||..:.:|.::|..|.:.:::||.|....|::.|.|   ..|....
Human   788 SNIPEITPFLMFIILGIPLPLGTITILCIDLGTDMVPAISLAYESAESDIMKRLP---RNPKTDN 849

  Fly   920 TMMKNILGQALYQLIIIFGL--LFVGDVIL-----------------------DIESGRGQE--L 957
            .:...::|.|..|:.:|..|  .|...|||                       |:|...||:  .
Human   850 LVNHRLIGMAYGQIGMIQALAGFFTYFVILAENGFRPVDLLGIRLHWEDKYLNDLEDSYGQQWTY 914

  Fly   958 NAGPTQHF---TIIFNTFVMM-------------TLFNEINARKIHGQRN--VIEGLLTNPIFYT 1004
            .......|   |..|.|.|::             :||.:       |.||  :|.|:|...:...
Human   915 EQRKVVEFTCQTAFFVTIVVVQWADLIISKTRRNSLFQQ-------GMRNKVLIFGILEETLLAA 972

  Fly  1005 IWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGH 1069
            ...:|....|.:..|        .|.:..||..|.:.|...|:.::      |||  ::   |.|
Human   973 FLSYTPGMDVALRMY--------PLKITWWLCAIPYSILIFVYDEI------RKL--LI---RQH 1018

  Fly  1070 PEEYTD 1075
            |:.:.:
Human  1019 PDGWVE 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	304/1156 (26%)
		Cation_ATPase_N	36..104	CDD:279080	17/80 (21%)
		E1-E2_ATPase	172..448	CDD:278548	68/284 (24%)
		Cation_ATPase	505..598	CDD:289987	26/108 (24%)
		HAD_like	676..807	CDD:119389	57/155 (37%)
		Cation_ATPase_C	873..1051	CDD:279079	47/222 (21%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ATP1A4	NP_653300.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37		1/1 (100%)
		ATPase-IIC_X-K	35..1029	CDD:273445	310/1176 (26%)
		Cation_ATPase_N	49..122	CDD:214842	19/88 (22%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	90..92		1/2 (50%)
		E1-E2_ATPase	154..373	CDD:278548	71/311 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	223..242		9/18 (50%)
		Cation_ATPase	435..527	CDD:289987	24/94 (26%)
		COG4087	609..758	CDD:226572	62/162 (38%)
		Cation_ATPase_C	805..1014	CDD:279079	50/234 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920