DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ATP12A

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_001172014.1	Gene:	ATP12A / 479	HGNCID:	13816	Length:	1045	Species:	Homo sapiens

Alignment Length:	1156	Identity:	309/1156 - (26%)
Similarity:	506/1156 - (43%)	Gaps:	256/1156 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PAQYGISLKQLRELM---------EHRG-REGVMKIAENGGIHELCKKLYTSPNE---------- 52
            |..|.:.|...::::         ::|| :...:::.:.....|..|:|:...::
Human     6 PEIYSVELSGTKDIVKTDKGDGKEKYRGLKNNCLELKKKNHKEEFQKELHLDDHKLSNRELEEKY 70

  Fly    53 ------GLSGSKADEEHRRETFGSN-VIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFY 110
                  |||.::|.|...|:  |.| :.|||.....:..:.:.:...::::...|.|..:.....
Human    71 GTDIIMGLSSTRAAELLARD--GPNSLTPPKQTPEIVKFLKQMVGGFSILLWVGAFLCWIAYGIQ 133

  Fly   111 KPADEDAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQ---NRIEGEHKFSV 172
            ..:|:.|.:   ...:.|.:.||        |||:|....|.:|.:...:.   |::..:... |
Human   134 YSSDKSASL---NNVYLGCVLGL--------VVILTGIFAYYQEAKSTNIMSSFNKMIPQQAL-V 186

  Fly   173 IRGGEVCQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVL 237
            ||..|...|....::||||.:||.||.:|||..::.|...:||.|||||||       :..|...
Human   187 IRDSEKKTIPSEQLVVGDIVEVKGGDQIPADIRVLSSQGCRVDNSSLTGES-------EPQPRSS 244

  Fly   238 SGTH--VMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDG 300
            ..||  .:|.......:...:.:....:.|:.|..::                      ||:
Human   245 EFTHENPLETKNICFYSTTCLEASTSPVGTVTGMVIN----------------------TGD--- 284

  Fly   301 RSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGY-- 363
                         .|:...|              :|.|:..|::|         |.:||:|.:
Human   285 -------------RTIIGHI--------------ASLASGVGNEK---------TPIAIEIEHFV 313

  Fly   364 ---AGSTIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTL 425
               ||..::: .::..||...:|..|:|.              :|..:.::|..|||||...||:
Human   314 HIVAGVAVSI-GILFFIIAVSLKYQVLDS--------------IIFLIGIIVANVPEGLLATVTV 363

  Fly   426 SLAYSVKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDI 490
            :|:.:.|:|.|.|.||::|:|.||:|:.:.||||||||||.|||||...:...::     .::|.
Human   364 TLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQI-----FVADT 423

  Fly   491 PQHVGNLITMGISVNSAYTSNIM-----AGHNPG--DLPIQ----VGNKTECALLGFVQGLGVKY 544
            .:...|.:....|...|..|.|:     |...||  ::||.    :|:.:|.|||.|.:.:....
Human   424 SEDHSNQVFDQSSRTWASLSKIITLCNRAEFKPGQENVPIMKKAVIGDASETALLKFSEVILGDV 488

  Fly   545 QSIRDEITEDKFTRVYTFNSVRKSMGTV--IPRPNG-GYRLYTKGASEIIMKKCA--FIYGHEGT 604
            ..||   ..::......|||..|...::  :..|:| .:.:..|||.|.|::||:  .|.|.|..
Human   489 MEIR---KRNRKVAEIPFNSTNKFQLSIHEMDDPHGKRFLMVMKGAPERILEKCSTIMINGEEHP 550

  Fly   605 LEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVP-GKAAINEVHI----DGEP---NWD-DE 660
            |:|.|                   .:|...||.:... |:..:...|:    |..|   ::| |.
Human   551 LDKST-------------------AKTFHTAYMELGGLGERVLGFCHLYLPADEFPETYSFDIDA 596

  Fly   661 ENIMTNLTCLCVVGI---EDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPND 722
            .|..|  :.||.||:   .||.|..||||:.||:.|||.|.|||||:..||::||...||:..|.
Human   597 MNFPT--SNLCFVGLLSMIDPPRSTVPDAVTKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANS 659

  Fly   723 DF-------LILEGKEFNRRIRDSNG---------DIQQHLIDKVWPKLR--VLARSSPTDKYTL 769
            :.       |.:..::.|:  ||:..         |:....:|::....:  |.||:||..|..:
Human   660 ETVEDIAHRLNIAVEQVNK--RDAKAAVVTGMELKDMSSEQLDEILANYQEIVFARTSPQQKLII 722

  Fly   770 VKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKA 834
            |:|     ......||||||||.||.|||||||:|.||||||:|.||.|:|::|.||||:|||..
Human   723 VEG-----CQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTG 782

  Fly   835 VMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEF 899
            |..||.::|::.|.:.:.||.|:..:....|........|:..:.:|:::|..|.:.|:|||.|.
Human   783 VEEGRLIFDNLKKTIAYSLTKNIAELCPFLIYIIVGLPLPIGTITILFIDLGTDIIPSIALAYEK 847

  Fly   900 PTPDLLLRKPYGRTK------PLISRTMMKNILGQALYQLIIIF------GLL----------FV 942
            ...|::.|||..:.|      ||...:.:...|.|||...::.|      |.|          :.
Human   848 AESDIMNRKPRHKNKDRLVNQPLAVYSYLHIGLMQALGAFLVYFTVYAQEGFLPRTLINLRVEWE 912

  Fly   943 GDVILDIESGRGQELNAGPTQH-----FTIIFNTFVMMTLFNEINARKIHGQRNVI--EGLLTNP 1000
            .|.:.|::...|||......::     :|..| ..:::....::..||.  :||.|  :||..|.
Human   913 KDYVNDLKDSYGQEWTRYQREYLEWTGYTAFF-VGILVQQIADLIIRKT--RRNSIFQQGLFRNK 974

  Fly  1001 IFYTIWIFTMISQV---LIIQYGKMAFSTKALT-LDQWLWCIFFGIGTLVW 1047
            :   ||: .:.||:   ||:.||..:.:..:.| |....|.:......|:|
Human   975 V---IWV-GITSQIIIGLILSYGLGSVTALSFTMLRAQYWFVAVPHAILIW 1021

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	309/1156 (27%)
		Cation_ATPase_N	36..104	CDD:279080	16/84 (19%)
		E1-E2_ATPase	172..448	CDD:278548	69/282 (24%)
		Cation_ATPase	505..598	CDD:289987	29/108 (27%)
		HAD_like	676..807	CDD:119389	57/148 (39%)
		Cation_ATPase_C	873..1051	CDD:279079	51/208 (25%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ATP12A	NP_001172014.1	ATPase-IIC_X-K	42..1045	CDD:273445	304/1120 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920