Protein Alignment PMCA and ATP1A3

DIOPT Version :9

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_001243143.1
• Gene: ATP1A3 / 478
• HGNCID: 801
• Length: 1026
• Species: Homo sapiens
• Alignment Length: 1135
• Identity: 303/1135 - (26%)
• Similarity: 476/1135 - (41%)
• Gaps: 287/1135 - (25%)

  Fly    15 LKQLRELMEHRGREGVMKIAENGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIPPKPPK 79
            ||:...:.||:           ..:.|:|:|..|...:||:.|||.|...|:  |.|.:.| ||.
Human    38 LKKEVAMTEHK-----------MSVEEVCRKYNTDCVQGLTHSKAQEILARD--GPNALTP-PPT 88

  Fly    80 T-------------FLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVLQEEEEHHGWIE 131
            |             |..|:|         |..:...::.|:   :...||.|        .|  :
Human    89 TPEWVKFCRQLFGGFSILLW---------IGAILCFLAYGI---QAGTEDDP--------SG--D 131

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQ----FRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIA 192
            .|.:.|.:..|||:|....|.:|.:    ....:|.:  ..:..|||.||..|::..:::|||:.
Human   132 NLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMV--PQQALVIREGEKMQVNAEEVVVGDLV 194

  Fly   193 QVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM-----VLSGTHVMEGSGKM 249
            ::|.||.:|||..:|.::..|||.|||||||:...:.||.   :|:     ....|:.:||:.:.
Human   195 EIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARG 259

  Fly   250 VVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRE 314
            ||.|.|..:..|.|.||
Human   260 VVVATGDRTVMGRIATL------------------------------------------------ 276

  Fly   315 TVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLT--VIILI 377
                                :||            |:...|.:||:|.:   .|.::|  .:.|.
Human   277 --------------------ASG------------LEVGKTPIAIEIEH---FIQLITGVAVFLG 306

  Fly   378 IQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVR 442
            :.|.|.:.::. ..|        ::.:|..:.::|..|||||...||:.|..:.|:|.:.|.||:
Human   307 VSFFILSLILG-YTW--------LEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVK 362

  Fly   443 HLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSA 507
            :|:|.||:|:.:.||||||||||.|||||...:...::.:. .|..|         ..|.|.:.:
Human   363 NLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEA-DTTED---------QSGTSFDKS 417

  Fly   508 YTSNIMAGHNPG------------DLPI----QVGNKTECALLGFVQGLGVKYQSIRDEITEDKF 556
            ..:.:...|..|            ::|:    ..|:.:|.|||..::......:.:|:   .:|.
Human   418 SHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRE---RNKK 479

  Fly   557 TRVYTFNSVRKSMGTV--IPRPNGG-YRLYTKGASEIIMKKCA--FIYGHEGTLEKFTRDMQERL 616
            .....|||..|...::  ...||.. |.|..|||.|.|:.:|:  .:.|.|..|::   :|:|..
Human   480 VAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDE---EMKEAF 541

  Fly   617 IREVIEPMACDGLRTISVAY-----RDFVPGKAAINEVHIDGEPNWD-DEENIMTNLTCLCVVGI 675
            ....:| :...|.|.:...:     ..|..|.|            :| |:.|..|:  .||.||:
Human   542 QNAYLE-LGGLGERVLGFCHYYLPEEQFPKGFA------------FDCDDVNFTTD--NLCFVGL 591

  Fly   676 E---DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEFNRRI- 736
            .   ||.|..||||:.||:.|||.|.|||||:..||::||...||        |.||.|....|
Human   592 MSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGI--------ISEGNETVEDIA 648

  Fly   737 ------------RDSNG---------DIQQHLIDKVWPKLR--VLARSSPTDKYTLVKGIIDSTV 778
                        ||:..         |.....||::.....  |.||:||..|..:|:|     .
Human   649 ARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEG-----C 708

  Fly   779 SENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYD 843
            .....:|||||||.||.|||||||:|.||||||:||:|:|:|:||.||||:|||..|..||.::|
Human   709 QRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFD 773

  Fly   844 SIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLLRK 908
            ::.|.:.:.||.|:..:....:...|....||..:.:|.::|..|.:.:::||.|....|::.|:
Human   774 NLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQ 838

  Fly   909 PYG-RTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVIL-----------------------DI 949
            |.. ||..|::..::....||  ..:|...|..|...|||                       |:
Human   839 PRNPRTDKLVNERLISMAYGQ--IGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDL 901

  Fly   950 ESGRGQE--LNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQRNVI--EGLLTNPIFYTIWIFTM 1010
            |...||:  ........||.....||.:.:....:......:||.:  :|:....:.:.::..|.
Human   902 EDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETA 966

  Fly  1011 ISQVLIIQYGKMAFSTKALTL-DQWLWCIF 1039
            ::..|....| |..:.:...| ..|.:|.|
Human   967 LAAFLSYCPG-MDVALRMYPLKPSWWFCAF 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	303/1135 (27%)
		Cation_ATPase_N	36..104	CDD:279080	21/80 (26%)
		E1-E2_ATPase	172..448	CDD:278548	70/285 (25%)
		Cation_ATPase	505..598	CDD:289987	24/113 (21%)
		HAD_like	676..807	CDD:119389	59/157 (38%)
		Cation_ATPase_C	873..1051	CDD:279079	41/196 (21%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ATP1A3	NP_001243143.1	ATPase-IIC_X-K	30..1026	CDD:273445	303/1135 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920