DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and ATP1A2

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	NP_000693.1	Gene:	ATP1A2 / 477	HGNCID:	800	Length:	1020	Species:	Homo sapiens

Alignment Length:	1153	Identity:	302/1153 - (26%)
Similarity:	472/1153 - (40%)	Gaps:	313/1153 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 GRE--GVMKIAENGG-------------------------IHELCKKLYTSPNEGLSGSKADEEH 63
            |||  .....|||||                         :.||.:|.....::||:..:|.:..
Human     6 GREYSPAATTAENGGGKKKQKEKELDELKKEVAMDDHKLSLDELGRKYQVDLSKGLTNQRAQDVL 70

  Fly    64 RRETFGSNVIPPKPPKT-------------FLTLVWEALQDVTLIILEVAALVSLGLSFYKPADE 115
            .|:  |.|.:.| ||.|             |..|:|         |..:...::.|:   :.|.|
Human    71 ARD--GPNALTP-PPTTPEWVKFCRQLFGGFSILLW---------IGAILCFLAYGI---QAAME 120

  Fly   116 DAPVLQEEEEHHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEG--EHKFSVIRGGEV 178
            |.|.          .:.|.:.:.:..|||||....|.:|.:...:.:..:.  ..:..|||.||.
Human   121 DEPS----------NDNLYLGVVLAAVVIVTGCFSYYQEAKSSKIMDSFKNMVPQQALVIREGEK 175

  Fly   179 CQISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDV---DPM----- 235
            .||:..:::|||:.:||.||.:|||..:|.|:..|||.|||||||:...:.|:.   :|:
Human   176 MQINAEEVVVGDLVEVKGGDRVPADLRIISSHGCKVDNSSLTGESEPQTRSPEFTHENPLETRNI 240

  Fly   236 VLSGTHVMEGSGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDG 300
            ....|:.:||:.:.:|.|.|..:..|.|.||                           .:|...|
Human   241 CFFSTNCVEGTARGIVIATGDRTVMGRIATL---------------------------ASGLEVG 278

  Fly   301 RSQIKGSQAPSQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAG 365
            |:.|                                 |.|..|     .:|. :|.:|:.:|.:
Human   279 RTPI---------------------------------AMEIEH-----FIQL-ITGVAVFLGVS- 303

  Fly   366 STIAVLTVIILIIQFCIKTFVIDEKPWKNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYS 430
                 ..|:.||:.:          .|        ::.:|..:.::|..|||||...||:.|..:
Human   304 -----FFVLSLILGY----------SW--------LEAVIFLIGIIVANVPEGLLATVTVCLTLT 345

  Fly   431 VKKMMKDNNLVRHLDACETMGNATAICSDKTGTLTTNRMTVVQSYICEKL--------------C 481
            .|:|.:.|.||::|:|.||:|:.:.||||||||||.|||||...:...::              .
Human   346 AKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGATFD 410

  Fly   482 KVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQS 546
            |..||.:.:.:..|   ....:|..|...||......     ..|:.:|.|||..::......:.
Human   411 KRSPTWTALSRIAG---LCNRAVFKAGQENISVSKRD-----TAGDASESALLKCIELSCGSVRK 467

  Fly   547 IRDEITEDKFTRVYTFNSVRKSMGTVIPRPNG--GYRLYTKGASEIIMKKCA--FIYGHEGTLEK 607
            :||.  ..|...: .|||..|...::..|.:.  .:.|..|||.|.|:.:|:  .:.|.|..|:|
Human   468 MRDR--NPKVAEI-PFNSTNKYQLSIHEREDSPQSHVLVMKGAPERILDRCSTILVQGKEIPLDK 529

  Fly   608 FTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAINEVHIDGEPNWDDEENIMTNLTCLCV 672
               :||:......:| :...|.|.:.....:...||..........|.|:..|:        ||.
Human   530 ---EMQDAFQNAYME-LGGLGERVLGFCQLNLPSGKFPRGFKFDTDELNFPTEK--------LCF 582

  Fly   673 VGIE---DPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFL--------- 725
            ||:.   ||.|..||||:.||:.|||.|.|||||:..||::||...||:...::.:
Human   583 VGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNI 647

  Fly   726 -------------ILEGKEFNRRIRDSNGDIQQHLIDKVWPKLR-----VLARSSPTDKYTLVKG 772
                         ::.|.:..        |:....:|::   |:     |.||:||..|..:|:|
Human   648 PMSQVNPREAKACVVHGSDLK--------DMTSEQLDEI---LKNHTEIVFARTSPQQKLIIVEG 701

  Fly   773 IIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMW 837
                 ......:|||||||.||.|||||||:|.||||:|:||:|:|:|:||.||||:|||..|..
Human   702 -----CQRQGAIVAVTGDGVNDSPALKKADIGIAMGISGSDVSKQAADMILLDDNFASIVTGVEE 761

  Fly   838 GRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTP 902
            ||.::|::.|.:.:.||.|:..:....:...|....||..|.:|.::|..|.:.:::||.|....
Human   762 GRLIFDNLKKSIAYTLTSNIPEITPFLLFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEAAES 826

  Fly   903 DLLLRKP-YGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVIL------------------- 947
            |::.|:| ..:|..|::..::....||  ..:|...|..|...|||
Human   827 DIMKRQPRNSQTDKLVNERLISMAYGQ--IGMIQALGGFFTYFVILAENGFLPSRLLGIRLDWDD 889

  Fly   948 ----DIESGRGQELNAGP------TQHFTIIFNTFVMMTLFNEI------NARKIHGQRN--VIE 994
                |:|...|||.....      |.| |..|.:.|::...:.|      |:....|.:|  :|.
Human   890 RTMNDLEDSYGQEWTYEQRKVVEFTCH-TAFFASIVVVQWADLIICKTRRNSVFQQGMKNKILIF 953

  Fly   995 GLLTN--------------------PIFYTIWIFTMISQVLIIQYGKM 1022
            |||..                    |:..|.|.......:||..|.::
Human   954 GLLEETALAAFLSYCPGMGVALRMYPLKVTWWFCAFPYSLLIFIYDEV 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	302/1153 (26%)
		Cation_ATPase_N	36..104	CDD:279080	20/105 (19%)
		E1-E2_ATPase	172..448	CDD:278548	73/283 (26%)
		Cation_ATPase	505..598	CDD:289987	23/96 (24%)
		HAD_like	676..807	CDD:119389	53/160 (33%)
		Cation_ATPase_C	873..1051	CDD:279079	46/208 (22%)
		ATP_Ca_trans_C	1096..1142	CDD:289209
ATP1A2	NP_000693.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		8/24 (33%)
		ATPase-IIC_X-K	30..1020	CDD:273445	294/1129 (26%)
		Interaction with phosphoinositide-3 kinase. /evidence=ECO:0000250	80..82		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..231		9/18 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920