DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PMCA and Atp2b4

DIOPT Version :9

Sequence 1:	NP_001014689.3	Gene:	PMCA / 43787	FlyBaseID:	FBgn0259214	Length:	1255	Species:	Drosophila melanogaster
Sequence 2:	XP_011246340.1	Gene:	Atp2b4 / 381290	MGIID:	88111	Length:	1239	Species:	Mus musculus

Alignment Length:	1221	Identity:	725/1221 - (59%)
Similarity:	885/1221 - (72%)	Gaps:	90/1221 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 DGRPAQYGISLKQLRELMEHRGREGVMKI-AENGGIHELCKKLYTSPNEGLSGSKADEEHRRETF 68
            :....::|.:|..||:|||.||.:.|.:| |..||:.|:|.:|.|||.|||||:.||.|.||..|
Mouse    16 ESHEGEFGCTLMDLRKLMELRGADAVAQISAHYGGVQEICTRLKTSPIEGLSGNPADLEKRRLVF 80

  Fly    69 GSNVIPPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEE 125
            |.||||||.|||||.|||||||||||||||:||::||.||||:|...|..:.        :|||.
Mouse    81 GKNVIPPKRPKTFLELVWEALQDVTLIILEIAAIISLVLSFYRPPGGDNEICGHIASSPEEEEEG 145

  Fly   126 HHGWIEGLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGD 190
            ..|||||.|||.|||:||:||||||:|||:||||||:|||.|.|||:||.|::.|:.|.:|:|||
Mouse   146 ETGWIEGAAILASVIIVVLVTAFNDWSKEKQFRGLQSRIELEQKFSIIRNGQLIQLPVAEIVVGD 210

  Fly   191 IAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVG 255
            |||:||||||||||.|||.||||:||||||||||||||..|.|||:|||||||||||:|||||||
Mouse   211 IAQIKYGDLLPADGILIQGNDLKIDESSLTGESDHVKKTLDKDPMLLSGTHVMEGSGRMVVTAVG 275

  Fly   256 VNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRS-QIKGSQAPSQRETVTSE 319
            ||||.|||||||||: :|::.:.||.|.:.:.|.:.:|.....||.: :|   |..:.:|.:.||
Mouse   276 VNSQTGIIFTLLGAS-EEEDDDDKKKKGKKQGAPENRNKAKTQDGVALEI---QPLNSQEGLDSE 336

  Fly   320 ITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKT 384
              ..|.:...:|            ||||||||.|||:||:|||.||..::||||:|||:.|.:..
Mouse   337 --DKEKKIARIP------------KKEKSVLQGKLTRLAVQIGKAGLIMSVLTVVILILYFVVDN 387

  Fly   385 FVIDEKPW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLD 445
            |||..:.|    ...|....||..||||||||||||||||||||:||||||||||||||||||||
Mouse   388 FVIQRREWLPECTPVYIQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLD 452

  Fly   446 ACETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTS 510
            ||||||||||||||||||||.|||||||:||.....:.:|.....|..|..||..|||:|.||||
Mouse   453 ACETMGNATAICSDKTGTLTMNRMTVVQAYIGGTHYRQIPQPDVFPPKVLELIVNGISINCAYTS 517

  Fly   511 NIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPR 575
            .|......|.||.||||||||.|||||..|...||::|:|:.|:|..:|||||||||||.|||.:
Mouse   518 KIQPPEKEGGLPRQVGNKTECGLLGFVTDLKQDYQAVRNEVPEEKLFKVYTFNSVRKSMSTVIRK 582

  Fly   576 PNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFV 640
            |.||:|:::||||||::::|..|...||.::.|....::.::|.||||||.:|||||.:|||||
Mouse   583 PEGGFRMFSKGASEIMLRRCDRILNKEGEIKSFRSKDRDNMVRNVIEPMASEGLRTICLAYRDF- 646

  Fly   641 PGKAAINEVHIDG-EPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDN 704
                       || ||:||.|..|:|:|.|:.||||||||||||||||.||:|||||||||||||
Mouse   647 -----------DGTEPSWDIEGEILTSLICIAVVGIEDPVRPEVPDAIAKCKRAGITVRMVTGDN 700

  Fly   705 INTARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTL 769
            :||||:||:|||||.|.||||.|||||||..||:..|:::|..:||:|||||||||||||||:||
Mouse   701 VNTARAIATKCGILTPKDDFLCLEGKEFNSLIRNEKGEVEQEKLDKIWPKLRVLARSSPTDKHTL 765

  Fly   770 VKGIIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKA 834
            ||||||||..|.|:|||||||||||||||||||||||||||||||||||||||||||||:|||||
Mouse   766 VKGIIDSTAGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKA 830

  Fly   835 VMWGRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEF 899
            |||||||||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.
Mouse   831 VMWGRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEP 895

  Fly   900 PTPDLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQH 964
            ||..||.|:||||.||||||||||||||.|:|||:|:|.|:|.||.:.||:|||...||:.|:||
Mouse   896 PTESLLRRRPYGRNKPLISRTMMKNILGHAVYQLLIVFLLVFAGDTLFDIDSGRKAPLNSPPSQH 960

  Fly   965 FTIIFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKAL 1029
            :||:|||||:|.||||||||||||::||..|:..|.||.|:.:.|...|::|::.|...||..:|
Mouse   961 YTIVFNTFVLMQLFNEINARKIHGEKNVFAGVYRNIIFCTVVLGTFFCQIMIVELGGKPFSCTSL 1025

  Fly  1030 TLDQWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEE----YTDGMNLGEERFDSID-S 1089
            |::||:||:|.|||.|:|||:|:::||:.|..:...|.|..:|    .|:||       |.|| :
Mouse  1026 TMEQWMWCLFIGIGELLWGQVISAIPTKSLKFLKEAGHGSDKEDISRDTEGM-------DEIDLA 1083

  Fly  1090 DKKPRAGQILWIRGLTRLQTQLRVIRAFR--STLEDLNERRSMH-------SLHSLRSPRTGIPV 1145
            :.:.|.|||||:|||.|:|||:.||..|:  :.|:.:.|..:.|       |.:|:|..:
Mouse  1084 EMELRRGQILWVRGLNRIQTQIDVINKFQTEAPLKRVRENMTQHLDVKLVPSSYSIRVVK----- 1143

  Fly  1146 AVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPDISYIDE 1196
                   |::.|        |:...:||    .:.::.:.|..|:....||
Mouse  1144 -------LFHNN--------HEVAHKPK----NRSSIHTFMTQPEYPADDE 1175

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	ATPase-IIB_Ca	1..1057	CDD:273668	683/1066 (64%)
		Cation_ATPase_N	36..104	CDD:279080	48/67 (72%)
		E1-E2_ATPase	172..448	CDD:278548	167/280 (60%)
		Cation_ATPase	505..598	CDD:289987	54/92 (59%)
		HAD_like	676..807	CDD:119389	105/130 (81%)
		Cation_ATPase_C	873..1051	CDD:279079	115/177 (65%)
		ATP_Ca_trans_C	1096..1142	CDD:289209	21/54 (39%)
Atp2b4	XP_011246340.1	ATPase-IIB_Ca	16..1053	CDD:273668	683/1066 (64%)
Atp2b4	XP_011246340.1	ATP_Ca_trans_C	1090..1169	CDD:372101	27/102 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848601
Domainoid	1	1.000	256	1.000	Domainoid score	I2017
eggNOG	1	0.900	-	-		E2759_KOG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1379	1.000	Inparanoid score	I125
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53587
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000362
OrthoInspector	1	1.000	-	-		otm42499
orthoMCL	1	0.900	-	-		OOG6_100143
Panther	1	1.100	-	-	O	PTHR24093
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R99
SonicParanoid	1	1.000	-	-		X220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790