Protein Alignment PMCA and atp2b1a

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_009298531.1
• Gene: atp2b1a / 378746
• ZFINID: ZDB-GENE-030925-29
• Length: 1257
• Species: Danio rerio
• Alignment Length: 1268
• Identity: 753/1268 - (59%)
• Similarity: 900/1268 - (70%)
• Gaps: 116/1268 - (9%)

  Fly    10 QYGISLKQLRELMEHRGREGVMKIAEN-GGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVI 73
            ::|.|||:||.|||.||.||:.||.|. |.::.||.:|.||..:||||..:|.|.|:..||.|.|
Zfish    21 EFGCSLKELRSLMELRGAEGLQKIQETYGDVNGLCNRLKTSAVDGLSGQPSDIEKRKAAFGQNFI 85

  Fly    74 PPKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADE-DAPVLQ------EEEEHHGWIE 131
            |||.|||||.||||||||||||||||||:||||||||||.|. |...::      |||...||||
Zfish    86 PPKKPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYKPPDAGDKNCVKGTGGEPEEEGETGWIE 150

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:||:.||:||||||:|||:||||||:|||.|.||||:|||:|.||.|.:|:||||||:||
Zfish   151 GAAILLSVVCVVLVTAFNDWSKEKQFRGLQSRIEQEQKFSVVRGGQVIQIHVAEIVVGDIAQIKY 215

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||||||..|.|.|:||||||||||||:||||||||||.|
Zfish   216 GDLLPADGILIQGNDLKIDESSLTGESDHVKKSLDKDAMLLSGTHVMEGSGKIVVTAVGVNSQTG 280

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKN--LTGENDGRSQIKGSQ-APSQRETVTSE--IT 321
            ||||||||..|:.:.|.|:.|||.:|..::||  ..|..:.|.:.|... |..:.:.:.|:  ..
Zfish   281 IIFTLLGAGEDDDDEEEKEKKKEKERKKEKKNKKQDGSVENRKKAKAQDGAAMEMQPLNSDEGAD 345

  Fly   322 KSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFV 386
            ..|....:||            ||||||||.||||||:|||.||..::.:|||||::.|.:.||.
Zfish   346 GEEKRKANLP------------KKEKSVLQGKLTKLAVQIGKAGLLMSAITVIILVVLFVVDTFW 398

  Fly   387 IDEKPWKN----TYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDAC 447
            :|:.||.:    .|....||..||||||||||||||||||||:||||||||||||||||||||||
Zfish   399 VDKIPWDSGCIPIYIQFFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDAC 463

  Fly   448 ETMGNATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNI 512
            ||||||||||||||||||.|||||||.:|.:|..:.:|....:|....:|:.:|||||.|||:.|
Zfish   464 ETMGNATAICSDKTGTLTMNRMTVVQVFIADKHYRKVPEPDVVPASTMDLLIVGISVNCAYTTKI 528

  Fly   513 MAGHNPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPN 577
            |:....|.|..|||||||||||||...|...||::|:||.|:|..:|||||||||||.||:...:
Zfish   529 MSPEKEGGLNRQVGNKTECALLGFALDLKKDYQAVRNEIPEEKLYKVYTFNSVRKSMSTVLKNDD 593

  Fly   578 GGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPG 642
            |.||:::||||||::|||..|....|..:.|....::.:::.||||||.:|||||.:||||| |.
Zfish   594 GSYRMFSKGASEILLKKCFKILTSTGEAKVFRPRDRDDMVKRVIEPMASEGLRTICLAYRDF-PA 657

  Fly   643 KAAINEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINT 707
            .        :|||:||:|.:|:|.|||:||||||||||||||||||||||||||||||||||:||
Zfish   658 S--------EGEPDWDNEADILTRLTCVCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNLNT 714

  Fly   708 ARSIASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKG 772
            ||:||:|||||:..||||.|||||||||||:..|:|:|..|||:|||||||||||||||:|||||
Zfish   715 ARAIATKCGILQVGDDFLCLEGKEFNRRIRNEKGEIEQERIDKIWPKLRVLARSSPTDKHTLVKG 779

  Fly   773 IIDSTVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMW 837
            ||||||.|.|:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   780 IIDSTVVEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMW 844

  Fly   838 GRNVYDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTP 902
            ||||||||:||||||||||||||||||.|||..||||||||||||||||||||||||||||.||.
Zfish   845 GRNVYDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTLASLALATEPPTE 909

  Fly   903 DLLLRKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTI 967
            .|||||||||.||||||||||||||.|:|||||||.|||.|:.:.:|:|||..:|:|.|::|:||
Zfish   910 SLLLRKPYGRNKPLISRTMMKNILGHAVYQLIIIFTLLFAGEKMFNIDSGRYADLHAPPSEHYTI 974

  Fly   968 IFNTFVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLD 1032
            :|||||||.||||||||||||:|||.||:..|.||.||...|.:.|::|:|:|...||...|.::
Zfish   975 VFNTFVMMQLFNEINARKIHGERNVFEGIFNNMIFCTIVFGTFVIQIVIVQFGGKPFSCVGLNIE 1039

  Fly  1033 QWLWCIFFGIGTLVWGQLITSVPTRKLPKILSWGRGHPEEYTDGMNLGE-ERFDSID-SDKKPRA 1095
            |||||||.|.|.|:|||:|:::||.:|..:.:.|.|..:|......|.| |..|.|| ::::.|.
Zfish  1040 QWLWCIFLGFGCLLWGQVISTIPTSRLTFLKTAGHGTQKEEIPDEELEELEDLDEIDHAERELRR 1104

  Fly  1096 GQILWIRGLTRLQTQ-----------------------------LRVIRAFRSTL---EDLNERR 1128
            |||||.|||.|:|||                             :||:.||||:|   |.|.:..
Zfish  1105 GQILWFRGLNRIQTQMDVVSAFQSGISFQAAVRRQPSSGSQQHDIRVVNAFRSSLSPYEGLEKPE 1169

  Fly  1129 SMHSLHSLRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQQEPKLPPQTQLNVSSGMMSPDISY 1193
            |..|:|:..:            ||.:..           :..||.:|           :..|...
Zfish  1170 SRTSIHNFMT------------HPEFRI-----------EDSEPHIP-----------LIDDTDA 1200

  Fly  1194 IDEDPQQQQRTLHNGLTSQRSSMPSNVPSSNQS 1226
            .|:.|.::..|          ..|...||.||:
Zfish  1201 EDDAPTKRNAT----------PTPPPPPSPNQN 1223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	594/874 (68%)
		Cation_ATPase_C	873..1051	CDD:376368	123/177 (69%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	24/76 (32%)
atp2b1a	XP_009298531.1	ATPase-IIB_Ca	10..1064	CDD:273668	703/1063 (66%)
		ATP_Ca_trans_C	1105..1182	CDD:463575	25/88 (28%)