Protein Alignment PMCA and ATP7

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: NP_572756.3
• Gene: ATP7 / 32142
• FlyBaseID: FBgn0030343
• Length: 1254
• Species: Drosophila melanogaster
• Alignment Length: 948
• Identity: 211/948 - (22%)
• Similarity: 347/948 - (36%)
• Gaps: 278/948 - (29%)

  Fly   181 ISVGDILVGDIAQVKYGDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEG 245
            |||..:..|||.:|..|..:|.||.::..:. ..|||.:||||..|.|        ..|:.|:.|
  Fly   540 ISVDYVQRGDILKVIPGAKVPVDGKVLYGHS-SCDESLITGESMPVAK--------RKGSVVIGG 595

  Fly   246 SGKMVVTAVGVNSQAGIIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAP 310
            |         :| |.|::..                  ||..       ||||
  Fly   596 S---------IN-QNGVLLV------------------EATH-------TGEN------------ 613

  Fly   311 SQRETVTSEITKSESEGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQI-GYAGSTIAVLTVI 374
                |..::|.:...|            |:|.        :|.:.:||.:| ||....:.|::.|
  Fly   614 ----TTLAQIVRLVEE------------AQTS--------KAPIQQLADRIAGYFVPFVVVVSSI 654

  Fly   375 ILIIQFCIKTFVIDEKPWKNTYANNLVKHLII-------GVTVLVVAVPEGLPLAVTLSLAYSVK 432
            .||....|.....:..|....:..::.::.||       .::||.:|.|..|.||...::..:..
  Fly   655 TLIAWIIIGFSNPNLVPVAMEHKMHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATG 719

  Fly   433 KMMKDNNLVRHLDACETMGNATAICSDKTGTLT-----TNRMTV-VQSYICEKLCKVLPTLSDIP 491
            ....:..||:...|.|.......:..|||||:|     |:::|: |.:.:| .|.:.|..:....
  Fly   720 TGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTLFVTAQVC-SLARALTIVGAAE 783

  Fly   492 QHVGNLITMGISVNSAYTSNIMAGHNPGDLPIQVGNKTECALLGFVQGLGVKY------QSIRDE 550
            |:..:.|...|   ..:..:::   |.|..| |.|:..:.:....|.|.|::.      |::|..
  Fly   784 QNSEHPIASAI---VHFAKDML---NVGATP-QAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQA 841

  Fly   551 ITEDKFTRVYTFNSVRKSMGTVIPRPNGGYRLYTKGASEIIMKKCAFIYGHEGTLEKFTRDM--- 612
            ...|   |:..:.::.::      .|.|...:....:.|.::.:.:.....|...::...|:
  Fly   842 CNAD---RIINYENLHRT------HPQGSVPVDNGASIEHLLPQRSVRKSMELNNQQLLSDLVLE 897

  Fly   613 -QERLI--REVIEPMACDGLRTISVAYRDFVPGKAAINEVHID-GEPNWDDEENIMTNLTC---- 669
             :|.|:  :::|:....    .:.:..|:::...|.  ||.:: .:....:|....|.:.|
  Fly   898 PEEELLTDQKIIDSPEI----LVLIGNREWMERNAI--EVPLEISDCMTHEERKGHTAVLCALNG 956

  Fly   670 --LCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSIASKCGILRPNDDFLILEGKEF 732
              :|:..:.|.|:||...|:...:|.||.|.::||||.|||.|||.:.||
  Fly   957 QLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGI--------------- 1006

  Fly   733 NRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDSTVSENREVVAVTGDGTNDGPA 797
                                  ..|.|...|:.|...::     .:..|...||:.|||.||.||
  Fly  1007 ----------------------RTVYAEVLPSHKVAKIQ-----RIQANGIRVAMVGDGVNDSPA 1044

  Fly   798 LKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNVYDSIAKFLQFQLTVNVVAVIV 862
            |.:||||..:. ||||||.|||||:|..::...:|..:...|.....|.....|....|::.:.:
  Fly  1045 LAQADVGITIA-AGTDVAAEASDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPL 1108

  Fly   863 AFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL---RKPYGRTKPLISRTMMKN 924
            | .|..|    |.....:.|    |.::|..|.:.......|||   |||..:|
  Fly  1109 A-SGLFA----PYGFTLLPW----MASVAMAASSVSVVCSSLLLKMYRKPTAKT----------- 1153

  Fly   925 ILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNTFVMMTLFNEINARKIHGQ 989
             |..|.|            :..|..|...|.|                      :|::...:|
  Fly  1154 -LRTAEY------------EAQLAAERASGSE----------------------DELDKLSLH-- 1181

  Fly   990 RNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLWCIFFGIGTLVWGQLITSV 1054
                .||...|                 :.|:|.|...:.:|...::...:|        .|||
  Fly  1182 ----RGLDDLP-----------------EKGRMPFKRSSTSLISRIFMHDYG--------NITS- 1216

  Fly  1055 PTRKLPKILSWGRG--HPEEYTDG-MNLGEERFDSIDS 1089
            |..|      :|.|  .|||..|| ..:...||.:.||
  Fly  1217 PDAK------YGEGLLDPEEQYDGRTKIVRSRFHANDS 1248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	178/775 (23%)
		Cation_ATPase_C	873..1051	CDD:376368	29/180 (16%)
		ATP_Ca_trans_C	1096..1141	CDD:463575
ATP7	NP_572756.3	CopZ	11..76	CDD:442020
		HMA	97..159	CDD:238219
		chaper_CopZ_Eh	212..276	CDD:411374
		HMA	287..350	CDD:238219
		P-type_ATPase_Cu-like	376..1130	CDD:319783	170/744 (23%)