Protein Alignment PMCA and Atp2b3

DIOPT Version :10

• Sequence 1: NP_001014689.3
• Gene: PMCA / 43787
• FlyBaseID: FBgn0259214
• Length: 1255
• Species: Drosophila melanogaster
• Sequence 2: XP_006528144.1
• Gene: Atp2b3 / 320707
• MGIID: 1347353
• Length: 1249
• Species: Mus musculus
• Alignment Length: 1264
• Identity: 748/1264 - (59%)
• Similarity: 903/1264 - (71%)
• Gaps: 101/1264 - (7%)

  Fly    11 YGISLKQLRELMEHRGREGVMKIAE-NGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            :|.:|.:||.|||.||.|.:.||.| .|.:..||::|.|||.|||:.:..|.|.||:.:|.|.||
Mouse    27 FGCTLAELRSLMELRGAEALQKIQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIP 91

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEEHHGWIE 131
            ||.|||||.||||||||||||||||||:||||||||.|..|::...        .|.|...||||
Mouse    92 PKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIE 156

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:|||.||:||||||:|||:||||||:|||.|.||:|||.|::.|:.|..::|||||||||
Mouse   157 GAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY 221

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||||:|..|.|||:|||||||||||:|||||||||||.|
Mouse   222 GDLLPADGVLIQGNDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTG 286

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSES- 325
            ||||||||..:|:|.:.||.|::              ||......::|..|...|..|:...:|
Mouse   287 IIFTLLGAGGEEEEKKDKKGKQQ--------------DGAMDSSQTRAKKQDGAVAMEMQPLKSA 337

  Fly   326 EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEK 390
            ||..:.:.....|  ...||||||||.||||||:|||.||..::.:|||||::.|.|:|||:|.:
Mouse   338 EGGEMEEREKKKA--NVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGR 400

  Fly   391 PW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            .|    ...|....||..||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   401 VWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 465

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
            ||||||||||||||||||||||||:.:...|.:|..|.:...:.:|:...||:|||||:.|:...
Mouse   466 NATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPE 530

  Fly   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR 581
            ..|.||.||||||||||||||..|...:|.:|::|.||:..:|||||||||||.|||..|:||:|
Mouse   531 KEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFR 595

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            |::||||||::|||..|....|.|..|....::.:::::||||||||||||.:|||||    :||
Mouse   596 LFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKKIIEPMACDGLRTICIAYRDF----SAI 656

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
            .      ||:||:|..::.:|||:.|||||||||||||:||||||||||||||||||||||||:|
Mouse   657 Q------EPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 715

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |:||||::|.:|||.|||||||||||:..|:|:|..:||||||||||||||||||:|||||||||
Mouse   716 AAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDS 780

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            |..|.|:|||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
Mouse   781 TTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNV 845

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            ||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..|||
Mouse   846 YDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL 910

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            ||||||.||||||||||||||.|:|||.|||.|||||::..||:|||...|::.|::|:||||||
Mouse   911 RKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNT 975

  Fly   972 FVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLW 1036
            ||||.||||||||||||:|||.:|:.:||||.||.:.|...|::|:|:|...||...|:.:||||
Mouse   976 FVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLW 1040

  Fly  1037 CIFFGIGTLVWGQLITSVPTRKLPKILSWGRG-HPEEYTD-GMNLGEERFDSIDSDKKPRAGQIL 1099
            |:|.|:|.|||||:|.::||.:|..:...|.| ..:|.|| .:..|||..|  .::::.|.||||
Mouse  1041 CLFVGVGELVWGQVIATIPTSQLKCLKEAGHGPGKDEMTDEELAEGEEEID--HAERELRRGQIL 1103

  Fly  1100 WIRGLTRLQTQ-----------------------------LRVIRAFRSTL-EDLNERRSMHSLH 1134
            |.|||.|:|||                             :||::||||:| |.|.:..|...:|
Mouse  1104 WFRGLNRIQTQMEVVSTFKRSGSFQGAVRRRSSVLSQLHDIRVVKAFRSSLYEGLEKPESKSCIH 1168

  Fly  1135 S-LRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQ--QEPKLPPQTQLN--VSSGMMSPDISYI 1194
            : :.:|...|      ....:|..|::...:...::  :.|..||..|.|  :.||:      |:
Mouse  1169 NFMATPEFLI------NDYTHNIPLIDDTDVDENEERLRAPPPPPPNQNNNAIDSGI------YL 1221

  Fly  1195 DEDPQQQQRTLHNGLTSQRSSMPSNVPSS 1223
                     |.| ...|..||..|:.|.|
Mouse  1222 ---------TTH-ATKSATSSAFSSRPGS 1240

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PMCA	NP_001014689.3	P-type_ATPase_Ca_PMCA-like	62..921	CDD:319776	586/871 (67%)
		Cation_ATPase_C	873..1051	CDD:376368	123/177 (69%)
		ATP_Ca_trans_C	1096..1141	CDD:463575	24/75 (32%)
Atp2b3	XP_006528144.1	ATPase-IIB_Ca	19..1061	CDD:273668	693/1059 (65%)
		ATP_Ca_trans_C	1100..1175	CDD:463575	23/74 (31%)