DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PMCA and Atp2b3

DIOPT Version :9

Sequence 1:NP_001014689.3 Gene:PMCA / 43787 FlyBaseID:FBgn0259214 Length:1255 Species:Drosophila melanogaster
Sequence 2:XP_006528144.1 Gene:Atp2b3 / 320707 MGIID:1347353 Length:1249 Species:Mus musculus


Alignment Length:1264 Identity:748/1264 - (59%)
Similarity:903/1264 - (71%) Gaps:101/1264 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 YGISLKQLRELMEHRGREGVMKIAE-NGGIHELCKKLYTSPNEGLSGSKADEEHRRETFGSNVIP 74
            :|.:|.:||.|||.||.|.:.||.| .|.:..||::|.|||.|||:.:..|.|.||:.:|.|.||
Mouse    27 FGCTLAELRSLMELRGAEALQKIQEAYGDVSGLCRRLKTSPTEGLADNTNDLEKRRQIYGQNFIP 91

  Fly    75 PKPPKTFLTLVWEALQDVTLIILEVAALVSLGLSFYKPADEDAPVL--------QEEEEHHGWIE 131
            ||.|||||.||||||||||||||||||:||||||||.|..|::...        .|.|...||||
Mouse    92 PKQPKTFLQLVWEALQDVTLIILEVAAIVSLGLSFYAPPGEESEACGNVSGGAEDEGEAEAGWIE 156

  Fly   132 GLAILISVIVVVIVTAFNDYSKERQFRGLQNRIEGEHKFSVIRGGEVCQISVGDILVGDIAQVKY 196
            |.|||:|||.||:||||||:|||:||||||:|||.|.||:|||.|::.|:.|..::|||||||||
Mouse   157 GAAILLSVICVVLVTAFNDWSKEKQFRGLQSRIEQEQKFTVIRNGQLLQVPVAALVVGDIAQVKY 221

  Fly   197 GDLLPADGCLIQSNDLKVDESSLTGESDHVKKGPDVDPMVLSGTHVMEGSGKMVVTAVGVNSQAG 261
            ||||||||.|||.||||:||||||||||||:|..|.|||:|||||||||||:|||||||||||.|
Mouse   222 GDLLPADGVLIQGNDLKIDESSLTGESDHVRKSADKDPMLLSGTHVMEGSGRMVVTAVGVNSQTG 286

  Fly   262 IIFTLLGAAVDEQEAEIKKMKKEAKRANKQKNLTGENDGRSQIKGSQAPSQRETVTSEITKSES- 325
            ||||||||..:|:|.:.||.|::              ||......::|..|...|..|:...:| 
Mouse   287 IIFTLLGAGGEEEEKKDKKGKQQ--------------DGAMDSSQTRAKKQDGAVAMEMQPLKSA 337

  Fly   326 EGNHLPQSSSSGAAETGHKKEKSVLQAKLTKLAIQIGYAGSTIAVLTVIILIIQFCIKTFVIDEK 390
            ||..:.:.....|  ...||||||||.||||||:|||.||..::.:|||||::.|.|:|||:|.:
Mouse   338 EGGEMEEREKKKA--NVPKKEKSVLQGKLTKLAVQIGKAGLVMSAITVIILVLYFVIETFVVDGR 400

  Fly   391 PW----KNTYANNLVKHLIIGVTVLVVAVPEGLPLAVTLSLAYSVKKMMKDNNLVRHLDACETMG 451
            .|    ...|....||..||||||||||||||||||||:||||||||||||||||||||||||||
Mouse   401 VWLAECTPVYVQYFVKFFIIGVTVLVVAVPEGLPLAVTISLAYSVKKMMKDNNLVRHLDACETMG 465

  Fly   452 NATAICSDKTGTLTTNRMTVVQSYICEKLCKVLPTLSDIPQHVGNLITMGISVNSAYTSNIMAGH 516
            ||||||||||||||||||||||||:.:...|.:|..|.:...:.:|:...||:|||||:.|:...
Mouse   466 NATAICSDKTGTLTTNRMTVVQSYLGDTHYKEIPAPSALTPKILDLLVHAISINSAYTTKILPPE 530

  Fly   517 NPGDLPIQVGNKTECALLGFVQGLGVKYQSIRDEITEDKFTRVYTFNSVRKSMGTVIPRPNGGYR 581
            ..|.||.||||||||||||||..|...:|.:|::|.||:..:|||||||||||.|||..|:||:|
Mouse   531 KEGALPRQVGNKTECALLGFVLDLKRDFQPVREQIPEDQLYKVYTFNSVRKSMSTVIRMPDGGFR 595

  Fly   582 LYTKGASEIIMKKCAFIYGHEGTLEKFTRDMQERLIREVIEPMACDGLRTISVAYRDFVPGKAAI 646
            |::||||||::|||..|....|.|..|....::.:::::||||||||||||.:|||||    :||
Mouse   596 LFSKGASEILLKKCTNILNSNGELRGFRPRDRDDMVKKIIEPMACDGLRTICIAYRDF----SAI 656

  Fly   647 NEVHIDGEPNWDDEENIMTNLTCLCVVGIEDPVRPEVPDAIRKCQRAGITVRMVTGDNINTARSI 711
            .      ||:||:|..::.:|||:.|||||||||||||:||||||||||||||||||||||||:|
Mouse   657 Q------EPDWDNENEVVGDLTCIAVVGIEDPVRPEVPEAIRKCQRAGITVRMVTGDNINTARAI 715

  Fly   712 ASKCGILRPNDDFLILEGKEFNRRIRDSNGDIQQHLIDKVWPKLRVLARSSPTDKYTLVKGIIDS 776
            |:||||::|.:|||.|||||||||||:..|:|:|..:||||||||||||||||||:|||||||||
Mouse   716 AAKCGIIQPGEDFLCLEGKEFNRRIRNEKGEIEQERLDKVWPKLRVLARSSPTDKHTLVKGIIDS 780

  Fly   777 TVSENREVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFSSIVKAVMWGRNV 841
            |..|.|:|||||||||||||||||||||||||||||||||||||||||||||:||||||||||||
Mouse   781 TTGEQRQVVAVTGDGTNDGPALKKADVGFAMGIAGTDVAKEASDIILTDDNFTSIVKAVMWGRNV 845

  Fly   842 YDSIAKFLQFQLTVNVVAVIVAFIGACAVQDSPLKAVQMLWVNLIMDTLASLALATEFPTPDLLL 906
            ||||:||||||||||||||||||.|||..|||||||||||||||||||.||||||||.||..|||
Mouse   846 YDSISKFLQFQLTVNVVAVIVAFTGACITQDSPLKAVQMLWVNLIMDTFASLALATEPPTESLLL 910

  Fly   907 RKPYGRTKPLISRTMMKNILGQALYQLIIIFGLLFVGDVILDIESGRGQELNAGPTQHFTIIFNT 971
            ||||||.||||||||||||||.|:|||.|||.|||||::..||:|||...|::.|::|:||||||
Mouse   911 RKPYGRDKPLISRTMMKNILGHAVYQLTIIFTLLFVGELFFDIDSGRNAPLHSPPSEHYTIIFNT 975

  Fly   972 FVMMTLFNEINARKIHGQRNVIEGLLTNPIFYTIWIFTMISQVLIIQYGKMAFSTKALTLDQWLW 1036
            ||||.||||||||||||:|||.:|:.:||||.||.:.|...|::|:|:|...||...|:.:||||
Mouse   976 FVMMQLFNEINARKIHGERNVFDGIFSNPIFCTIVLGTFGIQIVIVQFGGKPFSCSPLSTEQWLW 1040

  Fly  1037 CIFFGIGTLVWGQLITSVPTRKLPKILSWGRG-HPEEYTD-GMNLGEERFDSIDSDKKPRAGQIL 1099
            |:|.|:|.|||||:|.::||.:|..:...|.| ..:|.|| .:..|||..|  .::::.|.||||
Mouse  1041 CLFVGVGELVWGQVIATIPTS
QLKCLKEAGHGPGKDEMTDEELAEGEEEID--HAERELRRGQIL 1103

  Fly  1100 WIRGLTRLQTQ-----------------------------LRVIRAFRSTL-EDLNERRSMHSLH 1134
            |.|||.|:|||                             :||::||||:| |.|.:..|...:|
Mouse  1104 WFRGLNRIQTQMEVVSTFKRSGSFQGAVRRRSSVLSQLHDIRVVKAFRSSLYEGLEKPESKSCIH 1168

  Fly  1135 S-LRSPRTGIPVAVGGGHPLYNFNLLNPNYIKHQQQ--QEPKLPPQTQLN--VSSGMMSPDISYI 1194
            : :.:|...|      ....:|..|::...:...::  :.|..||..|.|  :.||:      |:
Mouse  1169 NFMATPEFLI------NDYTHNIPLIDDTDVDENEERLRAPPPPPPNQNNNAIDSGI------YL 1221

  Fly  1195 DEDPQQQQRTLHNGLTSQRSSMPSNVPSS 1223
                     |.| ...|..||..|:.|.|
Mouse  1222 ---------TTH-ATKSATSSAFSSRPGS 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PMCANP_001014689.3 ATPase-IIB_Ca 1..1057 CDD:273668 693/1059 (65%)
Cation_ATPase_N 36..104 CDD:279080 43/67 (64%)
E1-E2_ATPase 172..448 CDD:278548 168/280 (60%)
Cation_ATPase 505..598 CDD:289987 57/92 (62%)
HAD_like 676..807 CDD:119389 109/130 (84%)
Cation_ATPase_C 873..1051 CDD:279079 123/177 (69%)
ATP_Ca_trans_C 1096..1142 CDD:289209 24/76 (32%)
Atp2b3XP_006528144.1 ATPase-IIB_Ca 19..1061 CDD:273668 693/1059 (65%)
ATP_Ca_trans_C 1100..1175 CDD:372101 23/74 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 256 1.000 Domainoid score I2017
eggNOG 1 0.900 - - E2759_KOG0204
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H123775
Inparanoid 1 1.050 1379 1.000 Inparanoid score I125
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53587
OrthoDB 1 1.010 - - D115892at2759
OrthoFinder 1 1.000 - - FOG0000362
OrthoInspector 1 1.000 - - otm42499
orthoMCL 1 0.900 - - OOG6_100143
Panther 1 1.100 - - LDO PTHR24093
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R99
SonicParanoid 1 1.000 - - X220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1514.870

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